Navigation Links
Type 1 diabetes may result from good genes behaving badly
Date:9/19/2008

WHAT: New research from Stanford University scientists suggests that type 1 diabetes, an autoimmune disease that develops in children and young adults, may not be due to bad genes but rather to good genes behaving badly.

Because type 1 diabetes typically runs in families, scientists have looked for inborn genetic errors or gene variants passed on from generation to generation. Although this search has failed to find a single type 1 diabetes gene, many candidate type 1 diabetes susceptibility genes have been identified. These susceptibility genes, located in a region known as the major histocompatibility complex (MHC), help the body distinguish its own cells and tissues from those that are foreign.

Studies in identical twins, however, reveal that the situation is more complicated: often one twin develops type 1 diabetes while the other twin remains disease-free. This pattern of good luck/bad luck led researchers at Stanford to examine whether genetically at-risk individuals respond differently to environmental stimuli. In some cases, the immune system will respond in a benign fashion, while in other cases it will begin an inflammatory response that can ultimately lead to diabetes. The critical difference between health and disease might thus reside not in an individual's genetic blueprint but in how those genes are "expressed"--that is, how the translation of genetic information into proteins or RNA is switched on and off.

In a study supported by the National Institute of Allergy and Infectious Diseases, (NIAID) part of the National Institutes of Health, the Stanford team, led by C. Garrison Fathman, M.D., studied differences in gene expression between two groups of mice. The first group, non-obese diabetic mice, spontaneously develop type 1 diabetes. The second group, mice genetically identical to the first group except for their MHC genes, do not develop the disease. The researchers looked at gene expression in three different tis
'/>"/>

Contact: Bill Crews
crewsw@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Diabetes Spectrum Reports a Study Assessing the i-port(R) Injection Port for Administration of Insulin
2. Session highlights of the 1st World Congress on Interventional Therapies for Type 2 Diabetes
3. Weight-Loss Surgery Weighed as Diabetes Rx
4. American Diabetes Association Announces New Latino Diabetes Toolkit
5. American Diabetes Association Kicks 0ff Hispanic Heritage Month
6. Community-based diabetes prevention program shows promise
7. Once-Weekly Diabetes Drug Boosts Blood Sugar Control
8. Early trigger for type-1 diabetes found in mice, Stanford scientists report
9. Endocrinologists and surgeons join forces to fight type 2 diabetes
10. Nutraceuticals could prevent diabetes
11. Amylin Pharmaceuticals Diabetes Drug Byetta the Focus of California Lawsuit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... The world is at a "hinge ... to create new opportunities for leadership in health ... WesternU's 34th annual Commencement Exercises said Wednesday, May ... former San Francisco mayor and likely 2018 gubernatorial ... ceremony for WesternU's colleges of Allied Health Professions ...
(Date:5/22/2015)... May 22, 2015 Mountain Point Medical Center, ... ribbon cutting ceremony on Friday, May 29, 2015 at 11 ... 6 p.m. The new medical center, set to officially open ... Boulevard, Lehi, UT 84043. , “The opening of Mountain ... and the Utah County community,” said Kent Loosle, CEO of ...
(Date:5/22/2015)... Following yesterday’s announcement that Ascenta Health Limited has ... Nature’s Way, Marc St-Onge has affirmed his commitment to ... an integral part of the agreement with Nature’s Way ... develop Ascenta Skin into a leading player in the ... anti-aging skincare supplement featuring 6 active ingredients including therapeutic ...
(Date:5/22/2015)... NY (PRWEB) May 22, 2015 Hands ... that June 17, 2015, the Annual One Day Sale ... Since 2007, Hands On HCMT offers drastically reduced certificates one ... and estheticians have enough sessions, through what used to be ... is wonderful for the community as well. This once a ...
(Date:5/22/2015)... May 22, 2015 Carnegie Science ... today announced a new partnership to develop BodyTech, a ... region. The initiative includes a new exhibit at the ... demonstration theater, and a new traveling science show, Anatomy ... of 2015. , Designed to explore a wide ...
Breaking Medicine News(10 mins):Health News:Newsom to WesternU Grads: The Future is Inside You 2Health News:Newsom to WesternU Grads: The Future is Inside You 3Health News:Mountain Point Medical Center, a Campus of Jordan Valley Medical Center, Hosts Ribbon Cutting Ceremony and Community Celebration on Friday, May 29, 2015 2Health News:Ascenta Skin President Announces Plans to Grow Brand 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 3Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 2Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 3Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 4
... Shows 9% Increase In Revenues - - Florida Upholds Contract Award To ... ... - Regional Tender Work Underway In U.K. -, PRINCETON, ... of identity DNA testing,services, today reported its financial results for the second quarter of,2008., ...
... 31 Nutraceutical,International Corporation (Nasdaq: NUTR ) today ... 30, 2008. Net sales for the fiscal,2008 third quarter ... quarter of fiscal 2007. For the third quarter of ... earnings per share, compared to,net income of $2.9 million, ...
... NeoGenomics, Inc.,(OTC Bulletin Board: NGNM) today announced its results ... included,the following:, Second Quarter 2008 Highlights: -- ... 17% sequential increase in revenue vs. Q1 08 -- ... initiative -- Average number of tests/requisition increased 8.0% to ...
... Cardiva Medical, Inc., a,privately held medical device company, announced ... the BMO Capital Markets 2008 Focus on,Healthcare conference on ... Broadway Hotel in New York City. Mr. Lien,s presentation ... growth,strategy., Details of the presentation follow: ...
... Sentrx, a leading provider of drug safety services, gained four new ... strategy (REMS). The company was also awarded a significant contract expansion. ... ... -- Sentrx, a leading provider of http://www.sentrx.com/drug_safety_services.shtml [drug safety ...
... their arsenal in their quest for gold. The team and their mounts ... Fish Oil for Horses® and Omega-Cure™ for humans, provided by the Venice, ... ... July 31, 2008 -- The U.S. Olympic eventing squad has a new ...
Cached Medicine News:Health News:Orchid Cellmark Reports Second Quarter 2008 Financial Results 2Health News:Orchid Cellmark Reports Second Quarter 2008 Financial Results 3Health News:Orchid Cellmark Reports Second Quarter 2008 Financial Results 4Health News:Orchid Cellmark Reports Second Quarter 2008 Financial Results 5Health News:Orchid Cellmark Reports Second Quarter 2008 Financial Results 6Health News:Orchid Cellmark Reports Second Quarter 2008 Financial Results 7Health News:Orchid Cellmark Reports Second Quarter 2008 Financial Results 8Health News:Orchid Cellmark Reports Second Quarter 2008 Financial Results 9Health News:Nutraceutical Reports Q3 Results 2Health News:Nutraceutical Reports Q3 Results 3Health News:Nutraceutical Reports Q3 Results 4Health News:Nutraceutical Reports Q3 Results 5Health News:Nutraceutical Reports Q3 Results 6Health News:NeoGenomics Announces Results for the Second Quarter of Fiscal Year 2008 2Health News:NeoGenomics Announces Results for the Second Quarter of Fiscal Year 2008 3Health News:NeoGenomics Announces Results for the Second Quarter of Fiscal Year 2008 4Health News:NeoGenomics Announces Results for the Second Quarter of Fiscal Year 2008 5Health News:NeoGenomics Announces Results for the Second Quarter of Fiscal Year 2008 6Health News:NeoGenomics Announces Results for the Second Quarter of Fiscal Year 2008 7Health News:NeoGenomics Announces Results for the Second Quarter of Fiscal Year 2008 8Health News:Cardiva Medical Announces Presentation at BMO Capital Markets 2008 Focus on Healthcare Conference 2Health News:Sentrx Growth Continues with Four New Clients in Second Quarter 2Health News:Sentrx Growth Continues with Four New Clients in Second Quarter 3Health News:Fish Oil Fueling Equine Olympians 2Health News:Fish Oil Fueling Equine Olympians 3
(Date:5/22/2015)... May 22, 2015 According to ... by Product (Consumables, Instruments, Services), by Test Type (Indirect, ... Flow Cytometry), by End Users - Global Forecast to ... is expected to reach $736.85 Million by 2020 from ... 10.25%. Browse 71 market data Tables ...
(Date:5/22/2015)...  In a sweeping analysis assessing the current state ... researchers conclude that there remains considerable room for ... age groups, but especially for adolescents and young adults. ... treatment, underscoring the need to address barriers to care ... type 1 patients achieve optimal metabolic control. ...
(Date:5/21/2015)... 2015  When Ryan Rendino first felt ... his neck, he figured it was a ... off from weight lifting. But ... A series of doctor appointments ... Michel Kliot, MD , a ...
Breaking Medicine Technology:Oxidative Stress Assays Market Worth $736.85 Million by 2020 2Oxidative Stress Assays Market Worth $736.85 Million by 2020 3Oxidative Stress Assays Market Worth $736.85 Million by 2020 4Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 2Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 3Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 4Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 5Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 4
... Mass., Oct. 1 Echo Therapeutics, Inc. (OTC Bulletin ... the needle-free Symphony(TM) tCGM System as a non-invasive, wireless, ... SkinPrep System for transdermal drug delivery, announced today that ... will present at the 4th Annual JMP Securities Healthcare ...
... , PITTSBURGH, Oct. 1 In celebration of mothers and ... makers of Aquafresh® announced the "Amazing Mom" Celebration contest for ... invites children 6 years of age and older to write ... selected, Aquafresh will treat her and forty-nine other moms to ...
Cached Medicine Technology:Echo Therapeutics to Present at 4th Annual JMP Securities Healthcare Conference 2Aquafresh(R) Celebrates Amazing Moms in Phoenix 2
... patented ACS lenses offer the high resolution, ... the original clariVits. The simple two part ... its integrity during surgery. Simply autoclave, add ... then lock together for use. (ACS) AutoClave ...
... magnification and increased stereopsis, the ... for detailed visualization to the ... is ideal for vitrectomy in ... in proliferative vitreoretinopathy extending to ...
... Reinverting Operating Lens System® (ROLS) ... wide angle viewing system available ... unique single-element prism design, numerous ... viewing capability have made it ...
... Suturelysis lens provides unprecedented visibility of ... which, with other suturelysis lens designs, ... localized compressive forces and magnifies the ... resulting in enhanced visibility in difficult ...
Medicine Products: