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Type 1 Diabetes Treatment Disappoints in Trial
Date:2/2/2012

ents may alter the results of the trial because younger patients tend to lose beta cells faster, he noted.

Skyler said the first study showed promise only in a small subgroup of patients, not in the entire group. "You can't draw firm conclusions from pilot studies. There are a lot of things that look quite promising that don't pan out," he said.

But, Skyler added, "I personally don't think we should abandon GAD; I think we should think about the form it's in, and the route it's given."

Ludvigsson said further trials of GAD-alum are already on the way, using the drug as an intervention for people recently diagnosed with type 1 diabetes and as a preventive measure for people who have a high risk of developing type 1 diabetes.

More information

Learn more about type 1 diabetes from the American Diabetes Association.

SOURCES: Johnny Ludvigsson, M.D., Ph.D., professor, division of pediatrics, department of clinical and experimental medicine, Linkoping University, Sweden; Jay Skyler, M.D., professor, University of Miami Miller School of Medicine, and deputy director, clinical research, Diabetes Research Institute Foundation, Hollywood, Fla.; Feb. 2, 2012, New England Journal of Medicine


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