Navigation Links
Tylenol May Weaken Effectiveness of Kids' Vaccines

Giving analgesic to prevent fever at shot time could be counterproductive, researchers say

THURSDAY, Oct. 15 (HealthDay News) -- Fever after a vaccination is a normal and essential part of building an immune response, and giving children acetaminophen -- best known in the U.S. as Tylenol -- after a shot could dampen that response, a new study finds.

With some vaccines, transient fever means that a child's immune system is processing the immunization, providing them with the best protection, explained Dr. Robert T. Chen, a blood safety specialist at the U.S. Centers for Disease Control and Prevention.

Therefore, "unless your doctor specifically recommends it, do not administer fever-reducing medicines at the same time as vaccination to prevent your child from developing a fever," said Chen, who wrote an editorial accompanying a report in the Oct. 17 issue of The Lancet.

"It is still okay to use antipyretics [acetaminophen or ibuprofen] to treat a fever, but just not recommended to prevent fever," he added. "High fevers can be serious, especially in infants. It is important to work with your doctor to provide the best care for your child."

For the study, a research team led by Dr. Roman Prymula, from the University of Defence in Hradec Kralove, Czech Republic, did two studies, one when children received their first vaccination and another when they received their booster shot.

The vaccinations were routine for protection against pneumococcal disease, Haemophilus influenzae type b (Hib), diphtheria, tetanus, whooping cough, hepatitis B, polio and rotavirus.

The 459 infants in the studies were randomly assigned to get acetaminophen every six to eight hours for 24 hours after vaccination or no acetaminophen.

Prymula's team found that fewer infants who received acetaminophen had a fever, but these babies also had significantly fewer antibodies against pneumococcal disease, Haemophilus influenzae type b, diphtheria and tetanus toxoids, and for one of the whooping cough antibodies compared with infants who did not get acetaminophen.

They believe the pain reliever's anti-inflammatory activity might trigger "interference" to healthy immune system antibody responses, explaining the weakened immunization.

"Unless there are specific reasons for controlling fever, for example, in a child with history of febrile convulsions, Tylenol and other fever reducers should not be routinely given along with immunizations," Chen said.

Infectious disease expert Dr. Marc Siegel, an associate professor of medicine at New York University School of Medicine in New York City, said that "the conclusion that Tylenol not only suppresses fever, but also decreases immune response is plausible. After all, what is an immune response? It's an inflammatory response."

Siegel agrees that acetaminophen should not be routinely given to infants to prevent fever after vaccination. "But, if the kid is sick, treat the sickness. If the kid is very sick, I would get the fever down," he said.

And what about the vaccine for the H1N1 flu? According to Siegel, "giving an infant Tylenol before an H1N1 flu vaccine shot may not be a problem, because the immune response to the vaccine has been so robust."

More information

For more information on vaccines, visit the U.S. Centers for Disease Control and Prevention.

SOURCES: Robert T. Chen, M.D., blood safety specialist, U.S. Centers for Disease Control and Prevention, Atlanta; Marc Siegel, M.D., associate professor, medicine, New York University School of Medicine, New York City;Oct. 17, 2009, The Lancet

Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Terri Lynne Lokoff Child Care Foundation Announces Recipients of the 2009 Terri Lynne Lokoff/Childrens TYLENOL(R) National Child Care Teacher Awards(TM)
2. Its Cold Outside! Warm Up in Select Downtown Boston Heated Bus Shelters Courtesy of TYLENOL(r) Warming Liquids
3. Its Cold Outside! Warm Up in Select Downtown Chicago Heated Bus Shelters Courtesy of TYLENOL(r) Warming Liquids
4. The Makers of TYLENOL(R) Warming Liquids Offer Free Warming Taxi Rides in Washington, D.C.
5. The Makers of TYLENOL(R) Warming Liquids Offer Free Warming Taxi Rides in Select Philadelphia Areas
6. Acetaminophen May Weaken Effectiveness of Kids Vaccines
7. Medical Offices Feeling Pain of Weakened Economy
8. Economic Stimulus Law Weakens Americans Control Over Personal Health Information
9. New strategy to weaken traumatic memories
10. Purdue study projects weakened monsoon season in South Asia
11. Enzyme weakens the heart
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from reveals that behind the ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
Breaking Medicine Technology: