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Two-lock box delivers cancer therapy
Date:5/6/2014

ere just looking for one protease, it might be at the cancer site, but it could also be somewhere else in your body where you have inflammation. This could lead to undesirable side effects," she said. "By requiring two different proteases let's say protease A and protease B to open the locked virus, we may achieve higher delivery specificity since the chance of having both proteases elevated at a site becomes smaller."

In the future, molecular-imaging approaches will be used to detect both the identity and concentration of elevated proteases. "With that information, we would be able to pick a virus device from our panel of engineered variants that has the right properties to target that disease site. That's where we want to go," she said.

Suh said elevated proteases are found around many diseased tissues. She suggested these protease-activatable viruses may be useful for the treatment of not only cancers but also neurological diseases, such as stroke, Parkinson's and Alzheimer's diseases, and heart diseases, including myocardial infarction and congestive heart failure.

The ultimate vision of this technology is to design viruses that can carry out a combination of steps for targeting. "To increase the specificity of virus unlocking, you can imagine creating viruses that require many more keys to open," she said. "For example, you may need both proteases A and B as well as a cellular receptor to unlock the virus. The work reported here is a good first step toward this goal."


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Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

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