Navigation Links
Two common diabetes drugs double the risk of fractures in women
Date:12/9/2008

Two common diabetes drugs rosiglitazone and pioglitazone are linked to higher fracture rates in women, according to a meta-analysis in CMAJ by a team of researchers from the University of East Anglia in the United Kingdom and Wake Forest University in the United States http://www.cmaj.ca/press/080486.pdf.

The drugs, called thiazolidinediones, help improve glycemic control and decrease insulin resistance in patients with diabetes.

The researchers looked at 10 randomized controlled trials of at least one year's duration involving 13 715 diabetes patients taking thiazolidinediones and those not taking the therapy. They found significantly reduced bone density in the lumbar spine and at the hip in women on the drugs.

It appears that long-term thiazolidinedione use doubles the risk of fractures among women with type 2 diabetes, without a significant increase in fracture risk in men. The researchers estimate that a fracture would occur in 1 out of 21 women at high risk of fracture who are taking thiazolidinedione for one year and among low risk women, there would be 1 fracture in every 55 if these drugs are taken for more than a year.

With more than 4 million users of thiazolidinediones in the United States alone in 2006, "the public health impact may be considerable," write Dr. Yoon Loke and coauthors. "If one assumes that half of those users were women and that the baseline risk of fractures is similar to that found in the ADOPT study, an estimated 30 000 excess fractures may have occurred if these women had been prescribed thiazolidinediones rather than metformin for more than a year."

The researchers call for further investigation into the underlying causes of this apparent sex-specific effect.

In a related commentary http://www.cmaj.ca/press/081713.pdf, Dr. Lorraine Lipscombe of the Institute for
'/>"/>

Contact: Kim Barnhardt
kim.barnhardt@cma.ca
613-731-8610 x2224
Canadian Medical Association Journal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UK junior doctors gaining less experience of common procedures
2. New insights into common knee injuries
3. High and mighty: first common height gene identified by researchers behind obesity gene finding
4. Figure Skater Peggy Fleming, HealthSaver Says: Take Pains For Back Strains, 2nd Most Common Doctor Complaint
5. Exelixis Commences Public Offering of Common Stock
6. Common misdiagnosis: most women believe they have a yeast infection when they dont
7. Business Executives Discuss National Health Care Reform at Conference Sponsored by The Century Foundation, with Support from The Commonwealth Fund, and AARP
8. New Expert Report Dispels Common Myths About Aspartame
9. Common Foot Myths Trip Us Up
10. AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange
11. Allergy-Induced Asthma More Common in Affluent Countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Oct. 21, 2014 (HealthDay News) -- The United ... arriving from Ebola-affected nations of West Africa land ... them for infection with the virus. In ... Johnson noted that 94 percent of air passengers ... at one of these five airports -- New ...
(Date:10/22/2014)... Washington, D.C. (PRWEB) October 22, 2014 With ... November, a national survey by the American Institutes for Research ... they know how to use health insurance, but 42 percent ... review a plan’s details before signing up for coverage. , ... literacy, with only 20 percent able to calculate correctly how ...
(Date:10/22/2014)... Losing Weight Your Body’s Way , In a ... the face, it certainly can be difficult to choose the ... extra favor by doing it the healthy way? Set aside ... to your body, exercise regularly, and choose foods with the ... weight; you need to exercise more and eat less. Despite ...
(Date:10/22/2014)... 2014 Akeso Biomedical, Inc. , ... treatment of bacterial infections, microbial biofilms, and chronic wounds, ... board of directors. , Dr. Sinskey ... The Massachusetts Institute of Technology, or MIT. He has ... Dr. Sinskey also holds positions as Co-Director of the ...
(Date:10/22/2014)... Tara Haelle HealthDay Reporter ... drinking among young adult men may lead to increased blood ... didn,t cause a similar rise in blood pressure for young ... fact, when young adult women drank lightly or moderately, their ... study found. "This finding parallels studies in older adult ...
Breaking Medicine News(10 mins):Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4
... of death in Lake County , ... Evanston, IL (Vocus) March 12, ... a $1 million commitment to the Lake County Health Department and Community ... to addressing the steadily growing problem of diabetes in the county. , ...
... National Center for Creative Aging (NCCA) will feature certification on ... of the "NCCA-MetLife Foundation Creativity Matters: Health, Wellness, and ... March 30, 31, April 1 . Anne ... at the University of Wisconsin and Founder and ...
... Well-known for its preventive care initiatives, state,s largest ... American Lung Association to provide medical professionals the ... Live Well programCHARLESTON, W.Va., March 12 The ... UniCare Health Plan of West Virginia, Inc. (UniCare) ...
... finding and help fight obesity , , THURSDAY, March 12 (HealthDay ... may keep children more active and help combat the continued ... For every park found within a half-mile of home, a ... odds of taking part in leisure walking increased by 60 ...
... What,s Safe to Eat and Who,s Most At RiskLANSING, ... food safety legislation under debate in the U.S. Senate ... that Americans are more concerned than ever when it ... alarmingly unaware of the long-term side effects of Salmonella, ...
... the forthcoming 24th Annual EAU Congress in Stockholm (SE), which ... organizing three Meet the Expert sessions. These are press meetings ... in the Press Centre of the congress venue. In these ... the experts their questions practically one-on-one. , The first session,s ...
Cached Medicine News:Health News:NorthShore University HealthSystem Launches Diabetes Outreach Program for Lake County's Medically Underserved 2Health News:NorthShore University HealthSystem Launches Diabetes Outreach Program for Lake County's Medically Underserved 3Health News:NorthShore University HealthSystem Launches Diabetes Outreach Program for Lake County's Medically Underserved 4Health News:National Center for Creative Aging Features Timeslips in 'Creativity Matters' Symposium on Health, Wellness, and the Arts 2Health News:UniCare Health Plan of West Virginia Providing Assistance for Asthma Education Training 2Health News:UniCare Health Plan of West Virginia Providing Assistance for Asthma Education Training 3Health News:Kids Who Live Near Green Spaces Seem to Walk More 2Health News:Food Safety Expert: Americans Not Aware of Ongoing Risk & Complications of Salmonella Poisoning 2Health News:Food Safety Expert: Americans Not Aware of Ongoing Risk & Complications of Salmonella Poisoning 3Health News:Meet the expert sessions at the 24th Annual EAU Congress 2
(Date:10/22/2014)... October 22, 2014 A new ... Market (Product type, Form, End user, Application and Geography) ... Analysis, Research, Report, Opportunities, Segmentation and Forecast, 2013 - ... market. Based on key trends tracked, it is anticipated ... $7.9 billion by 2020, registering a CAGR of 6.2% ...
(Date:10/22/2014)...  With a vision to ensure safety and ... Pharmaceutical and Biotech manufacturer selects and implements the ... to protect their animal health brand.  ... Photo - http://photos.prnewswire.com/prnh/20141021/153439 ... by the Xyntek and Antares solution is an ...
(Date:10/22/2014)...   BioNano Genomics , the genome mapping ... to purchase an Irys™ System . Among them ... (NCI), NIH Intramural Sequencing Center (NISC) and Genoscope (The ... comprehensive view of a genome was a major ... deliver the scalability or reliability to detect and ...
Breaking Medicine Technology:Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4Xyntek and Antares Serialization Solution Protects Pets Too! 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3
... offers the most comprehensive family of ... for Cataract incision, Glaucoma filtration, and ... is achieved with minimal tissue trauma ... eraser styles are available in 18, ...
... Medtronic Ophthalmics offers the most ... specialty Eraser Instruments for Cataract incision, ... and discrete coagulation is achieved with ... cellular necrosis. Straight eraser styles are ...
... most comprehensive family of lightweight standard ... incision, Glaucoma filtration, and Vitreoretinal uses. ... with minimal tissue trauma and minimal ... are available in 18, 20, and ...
... most comprehensive family of lightweight standard ... incision, Glaucoma filtration, and Vitreoretinal uses. ... with minimal tissue trauma and minimal ... are available in 18, 20, and ...
Medicine Products: