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Two cardiovascular proteins pose a double whammy in Alzheimer's
Date:12/21/2008

id beta in their blood vessels.

The first author of the study is Robert Bell, a graduate student in Zlokovic's laboratory who is in Department of Pathology and Laboratory Medicine's graduate program. He had searched for months, without success, for evidence of a direct effect on LRP-1 by SRF/myocardin. A subsequent literature search turned up findings that the molecules might affect SREBP2. With that finding, the team was able to move forward and put the whole picture together.

Now the team has turned its attention to studying the role of hypoxia, which seems to play a role in turning on myocardin, as well as searching for molecules that block the hookup between SRF and myocardin.


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Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

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