Navigation Links
Two breath compounds could be associated with larynx cancer
Date:4/28/2014

Researchers at the Rey Juan Carlos University and the Alcorcn Hospital (Madrid) have compared the volatile substances exhaled by eleven people with cancer of larynx, with those of another twenty healthy people. The results show that the concentrations of certain molecules, mainly ethanol and 2-butanone, are higher in individuals with carcinoma, therefore they act as potential markers of the disease.

Human breath contains thousands of volatile organic compounds (VOC) and some of them can be used as non-invasive biomarkers for various types of head and neck cancers as well as cancer of the larynx.

This was shown in the experiment carried out by scientists from the Rey Juan Carlos University (URJC) with 31 volunteers: 20 healthy subjects (half of which are smokers) and 11 with cancer of the larynx in various phases of the disease and who are being treated in the Alcorcn Hospital in Madrid.

The results, published in the journal 'Chromatographia', reveal that the air exhaled by the more seriously ill patients in a stage called T3 contains different concentrations of seven compounds compared with the levels of healthy people or even those with a less developed tumour (T1).

Specifically, in the graphics of individuals with advanced cancer, the peaks that represent ethanol (C2H6O) and 2-butanone (C4H8O) are particularly significant. These two compounds therefore become potential markers of laryngeal carcinoma.

"At the moment it is still a preliminary study and a wider sample has to be obtained," Rafael Garca, professor of Chemical Engineering at the URJC and co-author of the study told SINC, "but it is a step in the right direction, an alternative with regard to identifying biomarkers, not only for this type of cancer but for other more prevalent and serious ones such as lung cancer, where early detection is key".

As part of the experiment, the researchers asked the participants to breathe into tedlar bags after fasting for at least eight hours so there was no leftover food or drink on their breath.

The samples were then analysed with solid phase micro-extraction, gas chromatography and mass spectrometry techniques, which enable very small amounts of a substance to be separated and identified. The concentrations are around or slightly above the equipment's detection limits (40 nanograms/mL), which is equivalent to 40 ppb or parts per billion.

The ultimate aim of the research is to "create an electronic nose that can be used in hospitals and health centres for the early detection of these types of diseases," concluded Rafael Garca. This team, together with other Spanish and foreign research groups, is working hard to develop sensors capable of detecting diseases through breath analysis.

Head and neck cancers represent between 5% and 10% of all malignant tumours currently diagnosed in Spain. Every year nearly half a million new cases are detected worldwide, mainly attributed to tobacco and alcohol use and approximately 90% are laryngeal cancer. The study also identified four markers in the exhaled breath that are typical of smokers, such as benzene and furfural.


'/>"/>

Contact: SINC
info@agenciasinc.es
34-914-251-820
FECYT - Spanish Foundation for Science and Technology
Source:Eurekalert  

Related medicine news :

1. There is no beating the breathalyzer this St. Patricks Day (video)
2. Poison-breathing bacteria may be boon to industry, environment
3. Global Breath Analyzers Market is Expected to Reach USD 4.5 Billion in 2019: Transparency Market Research
4. Buteyko Breathing Technique Endorsed by Dr. Joseph Mercola
5. Chicago man breathes again thanks to Northwestern Medicine study
6. DWI Lawyer Evan Levow Says New Jersey State Needs to Find an Alternative to Breath Testing Alcotest Device
7. DWI Attorney Evan Levow Critical of NJ Breath Testing Program after Supreme Court Ruling, Urges Arrestees to Re-double Their Efforts to Protect Their Rights
8. Exhaled breath biomarker may detect lung cancer, study presented at Chest 2013
9. SafeToSleep Infant Breathing Monitor Nominated for Fifth National Parenting Award of 2013
10. Natural Remedies For Tonsil Stones
11. How “Beat Tonsil Stones” Helps People Get Rid Of Bad Breath Naturally – Vinamy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Two breath compounds could be associated with larynx cancer
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... ... luxurious collection of unique masks and serums that perfectly fuse the beauty of ... advancements, at the 2017 Indie Beauty Expo on August 23rd & 24th in ...
(Date:8/22/2017)... ... 2017 , ... The old adage “you are what you ... healthy foods. But this well-known piece of nutrition advice ignores that an individual’s ... not only on properties of the food but also on properties of the ...
(Date:8/22/2017)... , ... August 22, 2017 , ... ... pleased to announce the addition of Zack Tisch as the firm’s new Consulting ... KLAS-ranked healthcare IT consulting firm’s national accounts, from assisting clients with initial vendor ...
(Date:8/22/2017)... CA (PRWEB) , ... August 22, 2017 , ... ... cycle management (RCM) solutions, announced recently the availability of a new professional fee ... in appreciation for their service to the healthcare industry. E/M coding is complex ...
(Date:8/22/2017)... DFW Metroplex, TX (PRWEB) , ... August 22, 2017 , ... Five Star Glass is ... They provide repair and replacement of auto glass for most makes and models, in ... area in the USA. , They have been a family owned business for the ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... , Aug. 3, 2017  Agragen, LLC, ... company active in the biopharmaceutical, nutraceutical, and aquacultural ... development of its lead drug candidates, AGR131.  This ... proinflammatory cytokine from the blood of patients suffering ... and inflammatory bowel disease. ...
(Date:8/2/2017)... -- CaryRx, a next-generation full-service pharmacy, has announced the launch ... the Washington D.C. metropolitan area. CaryRx ... of medications through the convenience of its patient-friendly mobile app. ... one hour to any location in D.C. ... service to Washington D.C. ," says Areo ...
(Date:7/28/2017)... CHICAGO, July 28, 2017 Hill-Rom Holdings, Inc. ... fiscal third quarter ended June 30, 2017, and updated ... For the fiscal third quarter, ... to $0.68 per diluted share in the prior-year period. ... of $0.39 per diluted share primarily related to the ...
Breaking Medicine Technology: