Navigation Links
Two breath compounds could be associated with larynx cancer
Date:4/28/2014

Researchers at the Rey Juan Carlos University and the Alcorcn Hospital (Madrid) have compared the volatile substances exhaled by eleven people with cancer of larynx, with those of another twenty healthy people. The results show that the concentrations of certain molecules, mainly ethanol and 2-butanone, are higher in individuals with carcinoma, therefore they act as potential markers of the disease.

Human breath contains thousands of volatile organic compounds (VOC) and some of them can be used as non-invasive biomarkers for various types of head and neck cancers as well as cancer of the larynx.

This was shown in the experiment carried out by scientists from the Rey Juan Carlos University (URJC) with 31 volunteers: 20 healthy subjects (half of which are smokers) and 11 with cancer of the larynx in various phases of the disease and who are being treated in the Alcorcn Hospital in Madrid.

The results, published in the journal 'Chromatographia', reveal that the air exhaled by the more seriously ill patients in a stage called T3 contains different concentrations of seven compounds compared with the levels of healthy people or even those with a less developed tumour (T1).

Specifically, in the graphics of individuals with advanced cancer, the peaks that represent ethanol (C2H6O) and 2-butanone (C4H8O) are particularly significant. These two compounds therefore become potential markers of laryngeal carcinoma.

"At the moment it is still a preliminary study and a wider sample has to be obtained," Rafael Garca, professor of Chemical Engineering at the URJC and co-author of the study told SINC, "but it is a step in the right direction, an alternative with regard to identifying biomarkers, not only for this type of cancer but for other more prevalent and serious ones such as lung cancer, where early detection is key".

As part of the experiment, the researchers asked the participants to breathe into tedlar bags after fasting for at least eight hours so there was no leftover food or drink on their breath.

The samples were then analysed with solid phase micro-extraction, gas chromatography and mass spectrometry techniques, which enable very small amounts of a substance to be separated and identified. The concentrations are around or slightly above the equipment's detection limits (40 nanograms/mL), which is equivalent to 40 ppb or parts per billion.

The ultimate aim of the research is to "create an electronic nose that can be used in hospitals and health centres for the early detection of these types of diseases," concluded Rafael Garca. This team, together with other Spanish and foreign research groups, is working hard to develop sensors capable of detecting diseases through breath analysis.

Head and neck cancers represent between 5% and 10% of all malignant tumours currently diagnosed in Spain. Every year nearly half a million new cases are detected worldwide, mainly attributed to tobacco and alcohol use and approximately 90% are laryngeal cancer. The study also identified four markers in the exhaled breath that are typical of smokers, such as benzene and furfural.


'/>"/>

Contact: SINC
info@agenciasinc.es
34-914-251-820
FECYT - Spanish Foundation for Science and Technology
Source:Eurekalert  

Related medicine news :

1. There is no beating the breathalyzer this St. Patricks Day (video)
2. Poison-breathing bacteria may be boon to industry, environment
3. Global Breath Analyzers Market is Expected to Reach USD 4.5 Billion in 2019: Transparency Market Research
4. Buteyko Breathing Technique Endorsed by Dr. Joseph Mercola
5. Chicago man breathes again thanks to Northwestern Medicine study
6. DWI Lawyer Evan Levow Says New Jersey State Needs to Find an Alternative to Breath Testing Alcotest Device
7. DWI Attorney Evan Levow Critical of NJ Breath Testing Program after Supreme Court Ruling, Urges Arrestees to Re-double Their Efforts to Protect Their Rights
8. Exhaled breath biomarker may detect lung cancer, study presented at Chest 2013
9. SafeToSleep Infant Breathing Monitor Nominated for Fifth National Parenting Award of 2013
10. Natural Remedies For Tonsil Stones
11. How “Beat Tonsil Stones” Helps People Get Rid Of Bad Breath Naturally – Vinamy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Two breath compounds could be associated with larynx cancer
(Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
Breaking Medicine Technology: