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Two-Year Data Show Investigational Drug Liraglutide More Effective at Lowering Blood Sugar Than Glimepiride
Date:6/8/2009

(8 mg, once daily) in patients with type 2 diabetes. Patients were treated previously with diet/exercise or low doses of one oral antidiabetic drug (OAD). The trial had a 52-week randomized, double-blind period followed by the one year extension; 59% entered the extension period of the trial and 43% of these patients completed the full two-year study period.

LEAD(TM) 3: two-year data

    Two years                Liraglutide       Liraglutide       Glimepiride
     monotherapy             1.8 mg, QD        1.2 mg, QD        8 mg, QD
                             N=154             N=149             N=137

    Diabetes duration,
     years at baseline         5.0                5.0              5.0

    Previous treatment:
    % diet/exercise             35%                38%              34%
    % OAD monotherapy           65%                62%              66%

    A1C % at baseline          8.1                8.1              8.0

    BMI, kg/m(2) at
     baseline                   33                 33               33

    Change in A1C% from
     baseline                 -1.1               -0.9             -0.6

    Change in A1C%  from
     baseline (in
     patients with <3
     years' duration of
     diabetes)                -1.4               -1.1             -0.7

    % A1C <7.0%                 58                 53               37

    Change FPG (Fasting
     Plasma Glucose)
     mg/dL from baseline       -27                -24               -6

    Weight change, kg
     from baseline            -2.7               -2.1              1.1

    Minor hypoglycemic
     events/patient/year      0.23               0.21             1.76

Safety and tolerability of liraglutide

The rate of minor hypoglycemia was statistically significantly lower with both liraglutide dose groups compared to the glimepiride-treat
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SOURCE Novo Nordisk
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