Navigation Links
Two Targeted Therapies Likely Better Than One in Patients with Aggressive Lymphoma, Mayo Clinic Researchers Say
Date:5/18/2009

ORLANDO, Fla., May 18 /PRNewswire-USNewswire/ -- When combined with a cocktail of chemotherapy drugs, two monoclonal antibodies, instead of one, appear to offer superior results in patients with diffuse large B-cell lymphoma, according to Mayo Clinic researchers working with the North Central Cancer Treatment Group (NCCTG).

At the annual meeting of the American Society of Clinical Oncology (ASCO), researchers say that adding the targeted therapy epratuzumab to a regimen known as R-CHOP resulted in an overall 12-month survival of 88 percent in 78 patients. While they call that a very good outcome, the researchers were especially encouraged because the survival rate was 85 percent in patients with high-risk disease.

"These results are very good and very promising, and hopefully will be an important advance over treatment now being offered to patients with this cancer," says the study's lead author, Ivana Micallef, M.D., a Mayo Clinic hematologist. "But we cannot yet say that is so, since the two different regimens haven't been tested head to head."

"Still, we are eager to do a randomized, phase III study because when we compare our results to some other studies of R-CHOP, our findings do look better," she says. In general, those studies showed a 12-month progression-free survival (PFS) of 67 to 79 percent.

The NCCTG multi-institutional research network is planning a clinical trial that will randomize patients with high-risk diffuse large B-cell lymphoma to either this regimen, known as ER-CHOP, or to R-CHOP, the standard treatment. R-CHOP includes a combination of chemotherapy drugs (cyclophosphamide, doxorubicin, and vincristine),
'/>"/>

SOURCE Mayo Clinic
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Two targeted therapies likely better than one in patients with aggressive lymphoma
2. Children who view adult-targeted TV may become sexually active earlier in life
3. Targeted agent shows promise in biliary cancer study
4. Targeted Treatments Show Mettle Against Advanced Cancers
5. UCSF, Stanford Study Reveals Neural Networks Targeted in Brain Diseases
6. Adventist Midwest Health Engages Medium Blue Search Engine Marketing in Geographically-Targeted SEO Campaign
7. M. D. Anderson Cancer Center Acquires Leksell Gamma Knife Perfexion for Targeted Brain Lesion Treatments
8. Cancer Researcher Dan Von Hoff, M.D. Advocates for "Context of Vulnerability," A Powerful New Paradigm for Targeted Drug Development
9. Pearly Penile Papule Patients Can Successfully Be Treated with Targeted CO2 Technology at La Jolla Cosmetic Surgery Centre
10. Targeted nanospheres find, penetrate, then fuel burning of melanoma
11. Health Integrated Achieves NCQA Full Accreditation for Its Synergy Targeted Population Management(TM) Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Park Cities Pet Sitter , Inc. has announced ... donation drive that benefits the animal shelter and rescue communities. ... with the Humane Society of the United States’ Animal Shelter ... , As part of their participation, Park Cities Pet Sitter ... the Presents 4 Pets drive from their client base, as ...
(Date:8/20/2014)... PITTSBURGH, Aug. 20, 2014 A common approach to ... blood did not improve survival chances for people who ... experts at the University of Pittsburgh School of Medicine. ... PLOS One , suggest acute hemodialysis, an aggressive method ... failure, may not provide a definitive benefit to the ...
(Date:8/20/2014)... With 3943.8% growth, Connexion Point ranks number ... fastest growing companies. The Inc. 500 ranks Connexion Point 12th, ... Point is the #1 fastest growing company in Utah. , ... and its clients include four of the top 10 health ... and has offices and contact centers in Salt Lake City, ...
(Date:8/20/2014)... cancer - using Botox. A study presented in the ... shows that cancer growth could be suppressed by eliminating ... cancer stem cells. The approach thus treated the cancer. ... and efficient. The researchers have thus far tested the ... humans. , The nervous system is crucial in regulating ...
(Date:8/20/2014)... most common cause of endophthalmitis, a potentially blinding condition ... eye injections, are the well-known staphylococci ("staph") ... a study published in the August issue of ... years of cases at New York Eye and Ear ... study found that gram-positive bacteria, which include staph and ...
Breaking Medicine News(10 mins):Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 2Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 3Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 4Health News:Pitt analysis questions use of acute hemodialysis treatment 2Health News:With 3943.8% Growth, Connexion Point, a Leader in Contact Centers for Health Care, Ranks 86th on the Inc. 500 List as One of the Nation’s Fastest Growing Companies 2Health News:Treating gastric cancer -- with Botox 2Health News:Researchers pinpoint most common causes of dangerous eye infection post surgery and trauma 2Health News:Researchers pinpoint most common causes of dangerous eye infection post surgery and trauma 3
... Pills Can Make Headaches Worse, YONKERS, N.Y., ... from frequent headaches to talk to their doctors,before ... prescription,and over-the-counter pain medications can make headaches worse, ... who reports in,CR,s October issue on how some ...
... Resources and Helpline Now,Available, HARRISBURG, Pa., Sept. 2 ... Indoor Air Act fast approaching, the,Department of Health is ... the law that will ban smoking in most public ... Guidance and a downloadable toolkit for public places ...
... new presidential,administration on the way, health care reform ... on what may come, attendees of the 2008,Republican ... than,Halleland Health Consulting, which is making itself available ... group and its law firm parent -- Minneapolis-based,Halleland ...
... Inc.,(NYSE: CSA ) announces the signing of ... office building and outpatient treatment center in,Pensacola, Florida., ... first synergy project since the,closing of the merger ... Spencer Company). The project will include design/build,(architectural, engineering ...
... Californians took benefit of nation,s 1st such law, passed in ... with chronically ill kids have made use of California,s pioneering ... even aware it exists, according to researchers at the Rand ... family leave law. It is funded by employees through an ...
... Pollution, HARRISBURG, Pa., Sept. 2 The ... partnerships have,forecast an air quality action day for ... air quality forecast predicts Wednesday will be code ... Washington and,Westmoreland counties., The U.S. Environmental Protection ...
Cached Medicine News:Health News:Consumer Reports Urges Chronic Headache Sufferers to Examine Their Use of Pain Relief Drugs 2Health News:Consumer Reports Urges Chronic Headache Sufferers to Examine Their Use of Pain Relief Drugs 3Health News:PA Department of Health Reminds Businesses to Prepare to Implement Clean Indoor Air Act 2Health News:INTERVIEW AVAILABILITY: Halleland Health Consulting Makes Health Policy Expertise Available During RNC Week 2Health News:Cogdell Spencer Announces First Synergy Project in Pensacola, Florida 2Health News:Cogdell Spencer Announces First Synergy Project in Pensacola, Florida 3Health News:Paid Family Leave Program Goes Mostly Unused 2Health News:Air Quality Action Day Forecast Wednesday for Pittsburgh Region 2
(Date:8/20/2014)... Trovagene, Inc. (NASDAQ:   TROV), a developer ... two clinical studies will be presented at the 29th ... test for the detection of high risk strains of ... take place in Seattle from ... a new U.S. patent was issued earlier this year ...
(Date:8/20/2014)... , August 20, 2014 ... Conducted in the US  KalVista Pharmaceuticals ("KalVista"), ... edema (DME), today announces that it has begun a ... plasma kallikrein inhibitor, KVD001, for the treatment of DME. ... of the Beetham Eye Institute, Joslin Diabetes Center; Harvard ...
(Date:8/19/2014)... , Aug. 19, 2014 Minimally Invasive Devices ... medical device company, announced today that Mitsubishi Corporation has ... robotic visualization system in Japan . ... in Japan in the second ... the exclusive distributor for Karl Storz GMBH & Co. ...
Breaking Medicine Technology:Trovagene Provides Update on Its Urine-Based HPV Test 2Trovagene Provides Update on Its Urine-Based HPV Test 3KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 2KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 3KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 4Minimally Invasive Devices and Mitsubishi Medical Japan Forge Exclusive Distribution Agreement 2