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Two Leading Alzheimer's Disease Researchers Recognized with MetLife Foundation Awards
Date:5/15/2013

New York, NY (PRWEB) May 15, 2013

MetLife Foundation today announced the recipients of its 2013 Awards for Medical Research in Alzheimer’s Disease: Yueming Li, Ph.D., member and professor, Sloan-Kettering Institute and director and professor, Graduate Program in Pharmacology, Weill Medical College of Cornell University, and Lennart Mucke, M.D., director, Gladstone Institute of Neurological Disease, Joseph B. Martin Distinguished Professor of Neuroscience and professor of Neurology, University of California, San Francisco (UCSF).

Dr. Li has shown how an enzyme known as gamma-secretase functions to produce amyloid-beta, a protein that accumulates as “plaques” in the brains of those with Alzheimer’s disease, damaging their neurons and connections. He has also developed a novel way to study the gamma-secretase complex, which is now enabling his lab and others to screen for potential treatments.

Dr. Mucke has identified molecular and cellular processes by which small assemblies of amyloid-beta impair cognitive functions. He demonstrated that these assemblies cooperate with tau, another protein that accumulates in Alzheimer brains, in disrupting the activity of brain networks. He also showed that suppressing the abnormal excitability of these networks can reverse cognitive and behavioral deficits in animal models of Alzheimer’s disease.

The winners were recognized at a scientific briefing and awards ceremony today in New York.

“MetLife Foundation is proud to present our awards to these outstanding researchers, whose work helps bring us closer to finding a cure for Alzheimer’s disease,” said Dennis White, president and chief executive officer, MetLife Foundation. “Doctors Li and Mucke have made significant contributions that have also enabled other scientists to explore promising new avenues of Alzheimer’s disease treatment.”

About the Awards

Now in their 27th year, the awards provi
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