Navigation Links
Two Genes Work in Tandem to Spur Deadliest Brain Cancer
Date:12/23/2009

Scientists discover the duo turns on hundreds of other genes that help disease spread

WEDNESDAY, Dec. 23 (HealthDay News) -- Two genes working in concert seem to spur the deadliest form of brain tumor, glioblastoma, the disease that took Sen. Ted Kennedy's life last August.

Scientists reporting in the Dec. 23 online edition of Nature said that the dynamic duo of genes are turned on in about 60 percent of patients with glioblastoma, and that those patients have an especially bad prognosis.

"We discovered that tumors expressing these two genes displayed much worse clinical outcomes. This is remarkable given that it's based on [just] the activity of two genes," said study senior author Dr. Antonio Iavarone, an associate professor of neurology at Columbia University Medical Center's Herbert Irving Comprehensive Cancer Center in New York City.

"These researchers have identified two transcription factors that appear to be causative. They're not just markers. They appear to actually cause the tumor," added Dr. Todd Waldman, an associate professor of oncology at Georgetown Lombardi Comprehensive Cancer Center in Washington, D.C. "For brain tumors, it's very exciting because it helps to explain why they are so devastatingly infiltrative."

Zeroing in on such specific targets brings the possibility of new therapies closer to the realm of reality.

"We are now trying to identify new compounds to block the function of the proteins," added Iavarone. "Some may be already available in the chemical library. We're in good shape because we know what we want to find, we know what the drug should do."

Glioblastomas multiforme -- dubbed "The Terminator" by one group of researchers -- are devastating because they so easily and quickly invade healthy brain tissue surrounding the tumor.

Scientists have been trying without huge success to understand why these tumors are so wildly aggressive.

Iavarone and colleagues determined that each of these newly identified genes -- C/EPB and Stat3 -- caused little damage on their own but, in tandem, wreaked havoc by switching on hundreds of other genes.

After almost a year, all patients in the study who had both genes turned on had died versus only one-half of those who had different types of tumors.

"These are not markers but master regulators of the most aggressive phenotype of brain tumor," Iavarone said. "Markers can tell us certain features of tumors but they're not the real engine behind the tumors. We have found the real driver making the tumors."

Turning off the genes in human brain tumor cells rendered them incapable of forming tumors when injected into mice.

More information

The U.S. National Cancer Institute has more on brain tumors.



SOURCES: Antonio Iavarone, M.D., associate professor, neurology, Columbia University Medical Center's Herbert Irving Comprehensive Cancer Center, New York City; Todd Waldman, M.D., Ph.D., associate professor, oncology, Georgetown Lombardi Comprehensive Cancer Center, Washington, D.C.; Dec. 23, 2009, Nature, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Organogenesis Files PMA for CelTx(TM) for Oral Soft Tissue Regeneration
2. Marijuana, Alcohol Addiction May Share Genes
3. Leprosy Genes Identified
4. ThermoGenesis Corp. Names Healthcare Industry Executive Craig Moore to Board of Directors
5. Vitamin D May Be Tied to Heart Disease Via Genes
6. Western diets turn on fat genes
7. Asthma Combo Seems Less Influenced by Genes
8. Genes May Link Hip Fractures and Heart Disease
9. Slavica Bio Chem MindUp Cancer Project (HTDS) Research Led To The Identification Of Genes Associated With Lung Cancer Promotion And Progression
10. Genes behind increasingly common form of cancer identified
11. Genes signal late-stage laryngeal cancer, poorer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... 29, 2017 , ... Altima Technologies, Inc., the maker of ... center assets and audio-video devices has recently updated its Visio Stencils library with ... and download shapes and stencils from http://www.VisioStencils.com. , New devices were ...
(Date:3/29/2017)... ... 29, 2017 , ... HealthCareMandA.com will host an important webinar — Home Health ... ET. A recording of the webinar will also be made available following its live ... hospice companies are still popular targets for healthcare investors. This highly fragmented sector bounced ...
(Date:3/29/2017)... ... , ... Hamlin Dental Group, multi-location dental office in North Hollywood , ... are safe and effective options, and can be used alone or in conjunction with ... of care. , Dr. Hamid Reza of Hamlin Dental Group offers other treatments as ...
(Date:3/29/2017)... ... March 29, 2017 , ... The Wharton School of the University of ... W’81, have made a $10 million gift to establish the Ken Moelis and ... a pathway to a Wharton MBA for highly-qualified Penn undergraduates whose academic and career ...
(Date:3/28/2017)... ... March 28, 2017 , ... A recent Bellwether Education Partners’ ... the field must first improve teacher preparation program design. It then asserts that ... that decades of input- and outcome-based research has failed to improve teacher education. ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017  Designers of primary cell wearable medical and ... 50% and extend battery life with the MAX20310 ultra-low ... (PMIC) from Maxim Integrated Products, Inc. (NASDAQ: ... voltage of just 0.7V for new high-energy density battery ... well as the more common Alkaline battery architecture. With ...
(Date:3/29/2017)... 29, 2017   Dynatronics Corporation (NASDAQ: ... of Cynthia L. McHenry (Cyndi) as ... for leading Dynatronics manufacturing, distribution, and purchasing operations ... Dynatronics, CEO Kelvyn H. Cullimore, Jr. ... search process conducted by the company as it ...
(Date:3/29/2017)... AVIV, Israel , March 29, 2017 ... agreement in which Exeltis will obtain exclusive marketing rights for Neurim,s ... ... an age-appropriate drug targeted to treat sleep disorders in children with ... be the first sleep medication approved for children. The ...
Breaking Medicine Technology: