Navigation Links
Two Endometrial Cancer Treatments May Not Work
Date:12/12/2008

Studies suggest lymph removal, external beam radiation no help against early disease

FRIDAY, Dec. 12 (HealthDay News) -- Removal of the pelvic lymph nodes, as well as external beam radiation, should not be part of routine care for women with early endometrial cancer, two new studies show.

One study looked at removal of pelvic lymph nodes (pelvic lymphadenectomy), in addition to the standard treatments of hysterectomy and removal of both ovaries and both fallopian tubes (bilateral salpingo-oophorectomy -- BSO). Removal of pelvic lymph nodes is used to determine whether or not the cancer is present outside the uterus and as a therapeutic procedure.

This study included more than 1,400 women at 85 centers in four countries. The women, whose cancer was believed to be localized, were divided into two groups -- 704 underwent standard surgery (hysterectomy and BSO, peritoneal washing, and palpitation of para-aortic nodes), while the other 704 had standard surgery plus pelvic lymphadenectomy.

After a median follow-up of about three years, 88 women in the standard surgery group had died, compared with 103 in the pelvic lymphadenectomy group, which translates into a 16 percent greater risk of death. When the researchers looked at the combined chances of death or recurrent cancer, 107 women in the standard surgery group experienced one or the other, compared with 144 in the lymphadenectomy group, which translates into a 35 percent increased risk.

"This randomized trial has shown no evidence of a benefit for systematic lymphadenectomy for endometrial cancer in terms of overall, disease-specific, and recurrence-free survival. This study is one of the largest reported surgical gynecological cancer trials... Pelvic lymphadenectomy cannot be recommended as routine procedure for therapeutic purposes outside of clinical trials," concluded Dr. Ann Marie Swart, of the Medical Research Trials Unit in London, and colleagues.

The second study evaluated the effects of external beam radiotherapy (EBR). This therapy is typically offered to women who've had successful surgery for early endometrial cancer but are at increased risk of cancer recurrence.

The study included 905 women randomly selected to observation (453) or EBR (452) after surgery. EBR was delivered in 20 to 25 daily fractions up to the target dose.

After a median of 58 months follow-up, 68 women in the observation group and 67 in EBR group had died. Overall five-year survival was 84 percent in both groups.

The study found "no evidence of a benefit for external beam radiotherapy for early endometrial cancer at intermediate or high risk of recurrence, in terms of overall, disease-specific, and disease-specific recurrence-free survival. Combining these findings with data from other trials, we can exclude even a very small benefit of radiotherapy on overall survival."

The authors add that, "adjuvant external beam radiotherapy cannot be recommended as part of routine treatment to improve survival for women with early endometrial cancer at intermediate or high risk of recurrence, and brachytherapy [placement of small radioactive pellets near cancer site] might be preferred for local control."

The studies appear online and in an upcoming print issue of The Lancet.

More information

The U.S. National Cancer Institute has more about treatment for endometrial cancer.



-- Robert Preidt



SOURCE: The Lancet, news release, Dec. 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ovarian and Endometrial Cancer Patients Experience Improved Outcomes When Treated First by a Gynecologic Oncologist
2. Global view shows link between endometrial cancer and vitamin D status
3. Internal radiotherapy better than external for quality of life in endometrial cancer patients
4. More Than $2.4 Million Raised by National Halloween Promotion Partners to Help St. Jude Fight Childhood Cancer
5. Progress Made in Predicting Breast Cancer Risk
6. Risk Info for Breast Cancer Patients Too Confusing
7. HRT Users Who Get Breast Cancer Less Likely to Die
8. Prescription Drug Benefits for Medicare Patients with Cancer to Cost More in 2009
9. Early stage, HER2-positive breast cancer patients at increased risk of recurrence
10. American Cancer Society recognizes international tobacco control leaders
11. National Cancer Institute Selects Ogilvy Public Relations Worldwide for Comprehensive Multi-Year Communications Support
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Two Endometrial Cancer Treatments May Not Work
(Date:2/9/2016)... ... February 09, 2016 , ... Cirracore Enterprise ... enterprises move workloads to the cloud. Cirracore provides a secure VMware® vCloud ... traversing the Internet. Transformation Solutions (TSL Partners) provides a full range of ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... ... specialty pharmacies, announces today the continuation of the ‘Pay It Forward’ program into ... prescription referral received at our specialty pharmacy. , “Since our Pay It ...
(Date:2/9/2016)... ... February 09, 2016 , ... On January 12, 2016 Paul ... appointment after they noticed their furnace not producing any heat. Shortly after entering the ... cracked heat exchanger was leaking dangerous levels of carbon monoxide into the home, at ...
(Date:2/9/2016)... ... February 09, 2016 , ... The ... Herberger’s and Younkers department stores, announced it has raised $176,000 to benefit the ... Holden Comprehensive Cancer Center at the University of Iowa, The Lynn Sage Cancer ...
(Date:2/9/2016)... ... 09, 2016 , ... ZipHearing.com is proud to ... hearing aids , increase industry transparency, and promote awareness of hearing solutions ... “For the average consumer, the hearing aid industry is esoteric and difficult to ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... -- Axovant Sciences Ltd. (NYSE:  AXON), a leading clinical-stage ... today announced further details of three new clinical ... of Lewy body dementia, a disease affecting approximately ... of the three studies were recently initiated and ... quarter. In addition, the Company reported financial results ...
(Date:2/9/2016)... The new report "Global Diagnostic Ultrasound Devices Market Assessment ... reveals that global diagnostic ultrasound devices market was valued at US$ ... million by 2019 at a CAGR of 6.8% from 2015 to ... has been analyzed for six geographies of North America ... , Latin America , Middle-East ...
(Date:2/9/2016)... 2016 The new report "Global Blood Monitoring & Cardiac Monitoring Devices ... Consulting group reveals that global market for blood monitoring & cardiac ... expected to grow to US$ 24,830.1 million by 2019 at a ... America , Europe , Asia-Pacific ... and Africa . The three major ...
Breaking Medicine Technology: