Navigation Links
Two Drugs Found Equal in Treatment of Septic Shock
Date:2/27/2008

But vasopressin might be slightly better than norepinephrine in less severe cases

WEDNESDAY, Feb. 27 (HealthDay News) -- The artery-tightening medication vasopressin holds no overall advantage over an older drug, norepinephrine, in the treatment of severe septic shock, a new study finds.

But vasopressin did appear to be better for less severe cases in the study, said Dr. James. A Russell, a professor of medicine at the University of British Columbia and lead author of a report in the Feb. 28 issue of the New England Journal of Medicine.

Septic shock occurs when an infection, usually bacterial, overwhelms the body's natural defenses, causing drastic drops in blood pressure and blood flow. Quick treatment to raise blood pressure can reduce the death rate, which is high. In this study, more than 35 percent of those treated with either drug died in the first four weeks.

"Vasopressin has been widely used for the treatment of septic shock because of studies showing an improvement in blood pressure and function," Russell said. "There has never been a large study examining the effect on mortality. Our study showed that basically, vasopressin and norepinephrine are safe and equally effective overall."

The study included 778 people treated for septic shock in a number of hospitals in Canada, Australia and the United States. In the first 28 days, 35.4 percent of those given vasopressin and 39.3 percent of those treated with norepinephrine died -- a difference that was not statistically significant.

But there was a statistically significant difference among those with less severe septic shock, defined by the dose of norepinephrine needed to raise blood pressure the desired amount, Russell said. In that group -- about half the people in the study -- 26.5 percent of those given vasopressin died, compared to 35.7 percent of those given norepinephrine. The death rate for more severe cases was 44 percent with vasopressin treatment, 42.5 percent with norepinephrine treatment.

"In our hospital, patients with less severe septic shock are being treated with vasopressin," Russell said.

But perhaps the most important factor in treatment is time, said Dr. Joseph E. Parrillo, a professor of medicine at Robert Wood Johnson Medical School in Camden, N.J.

"Two previous papers suggest that the support you give to the patient, fluids and a vasopressor, are only effective if instituted within the first few hours after the onset of septic shock," Parrillo said. "One paper also suggested that giving an antibiotic early made a difference, with a 20 percent death rate if an antibiotic was given in the first hour, and 60 percent if given by hour six."

The choice of antibiotic to treat the infection underlying the condition is also important, he said. "It makes a difference if you use antibiotics to which the infectious organism is sensitive," Parrillo said. A broad-spectrum antibiotic is adequate in most cases, he added.

Recent guidelines issued in a joint effort by 11 medical organizations, led by the Society of Critical Care Medicine, stress the need for early antibiotic treatment, Parrillo said. The guidelines do not stress the use of one artery-tightening medication over another, but, "the feeling is that there is no reason to use vasopressin," he said.

More information

Causes and treatment of septic shock are described by the U.S. National Library of Medicine.



SOURCES: James A. Russell, professor, medicine, University of British Columbia, Vancouver, British Columbia, Canada; Joseph E. Parrillo, M.D., professor, medicine, Robert Wood Johnson Medical School, Camden, N.J.; Feb. 28, 2008, New England Journal of Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Abbott, Genentech and WEHI Collaborate to Research and Develop New Anti-Cancer Drugs
2. Drugs used for cancer-associated anemia linked with increased risk of blood clots, death
3. Anemia Drugs for Cancer Patients Increase Death Risk
4. China Nepstar Chain Drugstore to Acquire 68 Drugstores from Ningbo New Century Medical Ltd.
5. Many Patients Fail to Take Drugs After Heart Attack
6. Cure Diabetes with Weight Loss, Not Drugs, Expert Says
7. Drugs, Doctors and Death: Heath Ledger Becomes Another Victim
8. The Northern Illinois University Murders Due to Chemical Imbalances or Chemical Balancers - Drugs? - Fred A. Baughman Jr., MD, Neurologist/Child Neurologist
9. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
10. Cholesterol-Lowering Drugs May Ease Irregular Heartbeat
11. Free Drugs After Heart Attack Would Save Money, Lengthen Lives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Two Drugs Found Equal in Treatment of Septic Shock
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a ... has been awarded a contract by the Center for Medicare and Medicaid Services ... accelerate the enterprise use of Agile methodologies in a consistent and high value ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
(Date:10/12/2017)... ... 2017 , ... Health Literacy Innovations (HLI), creator of the ... the Cancer Patient Education Network (CPEN), an independent professional organization that shares best ... alliance. , As CPEN’s strategic partner, HLI will help support CPEN members ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... the Centers for Disease Control and Prevention (CDC), influenza vaccination should ... helping communities across Massachusetts , Connecticut ... shots through the end of the month. *Some exclusions apply ... ... is by the end of October, according to the Centers for Disease ...
(Date:10/2/2017)...  Eli Lilly and Company (NYSE: LLY ... quarter of 2017 on Tuesday, October 24, 2017. Lilly ... with the investment community and media to further detail ... will begin at 9 a.m. Eastern time. Investors, media ... of the conference call through a link that will ...
(Date:10/2/2017)... The Rebound mobile app is poised to become a vital ... prescription drug addiction. The app empowers users to develop an ... their dosage in a safe, controlled manner while maximizing well-being. ... 100,000 people to sign up will enjoy 3 months of ... ...
Breaking Medicine Technology: