Navigation Links
Two-Drug Combo Helps Teens With Migraines
Date:5/15/2012

By Amanda Gardner
HealthDay Reporter

TUESDAY, May 15 (HealthDay News) -- A two-drug combination that relieves migraines in adults also works well in adolescents, new research indicates.

Although the findings basically support what doctors are already doing, "it is nice to have this officially shown in a study in adolescents," said Dr. Ellen Drexler, associate director of neurology at Maimonides Medical Center in New York City.

Because the combination of Imitrex (sumatriptan) and naproxen sodium (Aleve and other brand names) isn't approved for use by the U.S. Food and Drug Administration for this age group, doctors must prescribe it "off label" to adolescents.

"There are no FDA-approved abortive [migraine] treatments for children," said Dr. Noah Rosen, director of the Headache Center at the Cushing Neuroscience Institute in Great Neck, N.Y. "This is the first really large-scale abortive treatment study for adolescents."

The study, funded and carried out by researchers at GlaxoSmithKline, which makes the sumatriptan/naproxen combined tablet, known as Treximet, appears in the May 14 issue of Pediatrics.

Migraines in children and adolescents are physiologically no different from migraines in adults, said Drexler, although migraines in younger people tend not to last as long.

Although treatments are similar to those used in adults, not many trials have formally tested their effectiveness in children and adolescents.

The class of drugs known as triptans are the most studied, but none of those trials have shown a great benefit, possibly because of a large placebo response, the study authors wrote.

Some 8 percent to 23 percent of children aged 11 and older experience migraines, the researchers stated.

For this study, the authors randomly assigned almost 600 teens and preteens -- 12 to 17 years old -- to either a placebo or one of three doses of the sumatriptan/naproxen combination over a period of 12 weeks.

The doses were 10 milligrams (mg) sumatriptan and 60 mg naproxen, 30/180 mg and 85/500 mg, respectively.

Between 23 percent and 29 percent of those who took one of the doses of sumatriptan/naproxen reported being pain-free within two hours of taking the drug, vs. 10 percent in the placebo group.

"This is a significant amount of people to be pain-free," said Rosen.

The 85/500 mg version of the drug showed greater benefit when taking into account pain relief and sensitivity to light and sound. Nausea rates, however, were no better than in the placebo group.

Participants receiving one of the other two doses of the drug combination had lower rates of nausea.

Rosen said that most previous studies looked at pain reduction only.

Side effects were minimal and the same in all groups.

The authors did state that the 10/60 mg combination may be the best choice for lower-weight adolescents with shorter-duration migraines, given that it was effective and reduced nausea.

Treximet was approved by the FDA for use in adults in 2008. It's unclear if GlaxoSmithKline will apply for a pediatric indication for the drug from the agency.

More information

The Cleveland Clinic has more on migraines in children and adolescents.

SOURCES: Ellen Drexler, M.D., associate director, neurology, Maimonides Medical Center, New York City; Noah Rosen, M.D., director, Headache Center, Cushing Neuroscience Institute, Great Neck, N.Y.; May 14, 2012, Pediatrics


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Late-stage ovarian cancer shows promise in two-drug phase I trial
2. Elderly Lung Cancer Patients Can Gain From Two-Drug Chemo: Study
3. Short-Term Drug Combo May Help Prevent Colon Cancer
4. Bone Marrow Cancer Patients May Benefit From Drug Combo
5. Drug Combo Staves Off Type 2 Diabetes
6. Binge Drinking, Hypertension a Deadly Combo
7. Exercise Combo Best for Type 2 Diabetes
8. New combo lung cancer therapy improves survival over single-line treatment
9. In Women, Diabetes Plus Depression a Deadly Combo
10. Risks May Outweigh Benefits for Blood Pressure Drug Combo
11. Diet-Exercise Combo Seems to Work Best for Obese Seniors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Two-Drug Combo Helps Teens With Migraines
(Date:12/2/2016)... ... December 02, 2016 , ... ... launch of its 60-day free trial program for all of the company’s desktop ... offer a truly hassle free experience. , FlexiSpot’s unique desktop risers use an ...
(Date:12/2/2016)... ... December 02, 2016 , ... The annual time frame to change Medicare ... Period), is ending December 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from ... (Part D) need to make changes during this period order for their new policy ...
(Date:12/2/2016)... ... December 02, 2016 , ... With the number of pain management ... injury, patients must find the one that works for them. When an inventor from ... machine that worked and decided to share it with others. , He developed a ...
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. Raffi Hovsepian, a leading ... the 2016 “Guide to America’s Top Plastic Surgeons” for seven consecutive years. The ... education, experience, and professional associations. , One the most frequently honored surgeons ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... of "Cardiovascular Health" in USA Today, which covers the innovative treatments, therapeutic technologies, ... while maintaining fulfilling lives. “We are prolonging life 6 years in the last ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... in the ECG Cables And ECG Leadwires Market owing to ... devices. On the other hand, the Asia-Pacific ... rate during the forecast period. The market players ... plc ( Ireland ), Koninklijke Philips N.V. ( ... ( China ), held major share of the ...
(Date:12/2/2016)... 2016 Quantum Radiology,s Mobile Breast Center (QR ... directly to women at the workplace, thereby maximizing convenience ... Delta Air Lines and SunTrust Bank, and community health ... of wellness initiatives. "I think it,s a ... them to have a mammogram without taking a large ...
(Date:12/2/2016)... Dec. 2, 2016  Eli Lilly and Company (NYSE: ... for 2017 and provide updated financial guidance for 2016 ... a conference call on that day with the investment ... guidance. The conference call will begin at ... can access a live webcast of the conference call ...
Breaking Medicine Technology: