Navigation Links
Two-Day Dialysis Interval Could Pose Danger: Study
Date:9/22/2011

By Mary Brophy Marcus
HealthDay Reporter

WEDNESDAY, Sept. 21 (HealthDay News) -- Waiting more than a day between dialysis treatments ups the risk of death and hospitalization in people with kidney disease, new research suggests.

Patients are more likely to die or head to the hospital for cardiovascular-related and other complications following a two-day interval between dialysis sessions compared to a one-day gap, concluded researchers from the U.S. Renal Data System (USRDS) and the University of Minnesota, both in Minneapolis.

"It shows an association between adverse outcomes and a two-day interval between dialysis sessions," said study author Dr. Robert Foley, deputy director of the USRDS Coordinating Center, whose observational study involved more than 32,000 people on hemodialysis.

Hemodialysis is the more common form of dialysis in the United States, said Dr. Martin Zand, a professor of medicine in the division of nephrology at the University of Rochester Medical Center in New York. Used by people whose kidneys function at about 15 percent or less, this machine-based treatment removes toxins and extra fluid from the blood. Zand said kidney failure patients typically visit an outpatient dialysis center three times a week for sessions that last roughly four hours.

"Most patients are on a Monday, Wednesday, Friday schedule, or a Tuesday, Thursday, Saturday schedule, so once a week, they're missing dialysis for two days instead of one," Zand explained.

More than 340,000 people with chronic kidney disease are on hemodialysis, according to the U.S. National Kidney Foundation. In 75 percent of cases, kidney failure is caused by diabetes and high blood pressure.

The study, published in the Sept. 22 issue of the New England Journal of Medicine, followed 32,065 dialysis patients, average age 62, for a little more than two years.

During that time, 41 percent died from all causes. The average annual death rates were 22 percent on the day after the two-day interval compared to 18 percent on other days. The findings showed cardiac-related death rates were higher after the two-day interval, 10.2 percent compared to 7.5 percent after a one-day gap. Cardiac arrest after the longer interval was 1.3 percent compared to 1 percent, and deaths from heart attack were 6.3 percent vs. 4.4 percent.

Hospital admission rates were also steeper following the longer wait between dialysis visits. Hospitalization rates for heart attack were 6.3 percent compared to 3.9 percent, and congestive heart failure admission rates were almost double after a two-day interval (29.9 percent vs. 16.9 percent). Hospitalization rates for stroke were also higher (4.7 percent vs. 3.1 percent).

"This is a terrific study. Well-designed and clearly written," said Dr. Ajay Singh, an associate professor of medicine at Harvard Medical School and a practicing nephrologist. While the authors do not discuss the potential explanation for their findings, Singh said it's possible that the higher risk of death and hospitalization associated with the longer wait time stems from excessive fluid buildup or an electrolyte abnormality, perhaps related to elevated potassium levels, that harm the heart. Potassium is a mineral that can build up in blood and cause an abnormal heartbeat called an arrhythmia.

"The take-away message of the study is really something that many of us have known from our clinical practices for years -- that the long two-day interval between dialysis treatments in somebody on a three-day-a-week schedule is a point of high risk for heart attacks, congestive heart failure and hospital admissions," Zand said. "It begs the question, do we need to re-examine the three-day-a-week schedule?"

Foley said it's too early to change dialysis protocol. "Our study suggests that alternate-day treatment versus conventional three times per week treatment is a trial that needs to be seriously considered," he said.

Foley also emphasized that studies like this that draw conclusions from associations "are shaky foundations" upon which to build new treatment guidelines. He said the next step should be a trial in which patients are randomly assigned to different dialysis schedules and their outcomes compared.

Zand said concerned patients might want to explore other dialysis options with their physicians, including daily home peritoneal dialysis or night-time outpatient hemodialysis, which could add additional blood-cleansing hours. He said they can also discuss taking extra steps to reduce the risk of complications on the two-day stretches between dialysis stints by minimizing fluid intake, salty foods and high-potassium foods, such as avocados and bananas.

More information

Find out more about kidney dialysis at the U.S. National Kidney Foundation.

SOURCES: Robert Foley, M.B., deputy director, U.S. Renal Data System Coordinating Center, Minneapolis; Martin Zand, M.D., Ph.D., professor, medicine, division of nephrology, University of Rochester Medical Center, Rochester, N.Y.; Sept. 22, 2011, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Dialysis Patients Unprepared for Disasters, Study Contends
2. Acne-treating antibiotic cuts catheter infections in dialysis patients
3. Younger Blacks Fare Worse on Dialysis, Study Finds
4. Blood Pressure Drop During Dialysis May Raise Clot Risk
5. Low blood pressure during dialysis increases risk of clots, according to Stanford-led study
6. HbA1C test for glucose monitoring poorly predictive in dialysis patients
7. Many Dialysis Patients Short on Health Literacy
8. Higher Death Rates Seen in Central Line Dialysis Patients: Study
9. Home Dialysis for Kidney Patients May Ease Restless Legs Syndrome
10. Portable, less costly peritoneal dialysis shows no additional catheter risk factors
11. Many Dialysis Patients at Risk for High Radiation Exposure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Two-Day Dialysis Interval Could Pose Danger: Study
(Date:5/26/2016)... ... May 26, 2016 , ... Georgia State University College ... academic programs. , Answering to the increasing demand for curricular specializations, the Certificate ... and environmental and land use law. ,  , “The demand for lawyers with ...
(Date:5/26/2016)... ... May 26, 2016 , ... On Memorial Day, Hope For ... their lives in military battle for the country. The nonprofit Hope For Heroes ... more programs that empower independence for disabled military veterans, as well as police, firemen, ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... one that has a significant negative impact on long-term patient survival, reports a ... The results, published online this week in the Journal of Thoracic and Cardiovascular ...
(Date:5/26/2016)... ... 2016 , ... MadgeTech will be showcasing its line of data logging ... at the MadgeTech headquarters. With products sold in more than 100 countries around the ... NASA. , In 2012, NASA strategically set up 17 RHTemp101A MadgeTech data ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. James Maisel will ... Long Island Chapter on June 4, 2016, 1:30-3:30 pm at the Farmingdale Public ... Retina Group of New York , is a Board Certified ophthalmologist who ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... WELLESLEY, Massachusetts , May 26, 2016 ... sequencing (NGS) has matured into an essential life science ... research and development applications. BCC Research reveals in its ... of a second growth phase, one powered by a ... applied fields.      (Logo: http://photos.prnewswire.com/prnh/20140723/694805 ...
(Date:5/25/2016)... May 25, 2016 According to ... Type (3D, 2D, 4D), by Therapeutic Area (Oncology, Cosmeceutical/Plastic ... User (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast to ... Medical Animation Market for the forecast period of 2016 ... 301.3 Million by 2021 from USD 117.3 Million in ...
(Date:5/25/2016)... and GERMANTOWN, Maryland , May 25, ... QGEN ; Frankfurt Prime Standard: QIA) today announced that the ... Therawis Diagnostics GmbH to develop and commercialize predictive assays in ... PITX2 as a marker to predict effectiveness of anthracycline treatment ... "We are pleased to partner with Therawis, which developed ...
Breaking Medicine Technology: