Navigation Links
Two Antioxidant Vitamins Don't Protect Against Heart Disease

Study highlights:

- A major long-term study of more than 14,000 physicians showed no cardiovascular protection from two antioxidant vitamins taken by much of the American population.

- Taken individually, vitamins E and C failed to protect against heart and blood vessel disease.

NEW ORLEANS, Nov. 11 /PRNewswire-USNewswire/ -- Vitamins E and C -- antioxidant supplements taken by many American adults -- don't protect against cardiovascular disease when taken individually, according to a long-term study of more than 14,000 male physicians presented at the American Heart Association's Scientific Sessions 2008. Results of the Physician's Health Study II (PHS II) were presented as a late-breaking clinical trial. The study was simultaneously published in the Journal of the American Medical Association.

"We found no compelling evidence that either individual vitamin E or vitamin C reduces the risk of cardiovascular disease," said J. Michael Gaziano, M.D., M.P.H., principal investigator of the study and a cardiologist at Brigham and Women's Hospital and VA Boston Healthcare System in Boston, Mass.

Gaziano said results of the study add to the growing consensus about vitamin E's lack of cardiovascular protection based on several earlier trials that failed to find any effect.

The randomized, double-blind, placebo-controlled trial included 14,641 U.S. physicians 50 and older. Cardiovascular disease in the study included nonfatal heart attack, nonfatal stroke and fatal cardiovascular disease

"This is one of the first large-scale, long-term clinical trials of individual vitamin C supplementation in the prevention of cardiovascular disease," said Howard D. Sesso, Sc.D., M.P.H., co-author and project director of PHS II and assistant professor of medicine at Brigham and Women's Hospital.

Unlike several earlier studies in which vitamins E and C were often given as part of an antioxidant cocktail, this study investigated the two vitamins individually, he said.

The findings are an example of the importance of randomized clinical trials to test promising hypotheses generated by laboratory or observational research, Sesso said. Antioxidant vitamins appeared promising in previous laboratory research and in observational human studies, in which people who reported eating a diet rich in vitamins E and C seemed to have fewer cardiovascular problems.

Fruits and vegetables may provide some protective effect beyond the vitamins they contain, or it could be that people who report eating a lot of fruits and vegetables have other characteristics that lead to better health, Sesso said.

Therefore, researchers needed a large, well-designed, placebo-controlled clinical trial -- one that included a dedicated group of participants.

Each year, the investigators mailed participants calendar packs containing each vitamin or its placebo, depending upon the group to which each physician had been randomly assigned. The doses used in the study (400 international units of vitamin E every other day and 500 milligrams of vitamin C daily) correspond to typical amounts available commercially, Gaziano said.

During an average eight years of follow-up, participants provided annual updates on compliance, various risk factors and health outcomes, allowing the investigators access to their medical records when necessary to confirm cardiovascular events or cause of death.

"Broadly speaking, there has been great interest in antioxidants in the prevention of cardiovascular disease," said Sesso. "Despite promising findings from laboratory research and observational studies, our results from PHS II point to the need for large-scale, long-term clinical trials testing the antioxidant hypothesis."

The final arm of PHS II, testing daily multivitamin supplementation, is ongoing.

Individual author disclosures are available on the abstract.

The study was funded by grants from the National Institutes of Health in Bethesda, Md., and an investigator-initiated grant from BASF Corporation in Florham Park, N.J. BASF Corporation, Wyeth Pharmaceuticals in Madison, N.J., and DSM Nutritional Products, Inc., formerly Roche Vitamins, in Parsippany, N.J., provided study agents and packaging.

Statements and conclusions of study authors that are presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at

SOURCE American Heart Association
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Susan Lark, MD Develops a Powerful ORAC Drink Packed with the Antioxidant Power of Nine Fruits
2. Too Much Sun, Too Few Antioxidants Spell Eye Trouble
3. Sunlight exposure plus low antioxidant levels may place older adults at risk for eye disease
4. Antioxidant-Rich Diet May Protect Against Eye Disease
5. Green Tea Antioxidant May Help Prevent Alzheimers
6. Antioxidant supplements may lessen benefit of radiation and chemotherapy
7. Cancer Patients Should Steer Clear of Antioxidants
8. New Antioxidant Drug Shows Promise Against Diabetes
9. Blueberry Juice Tops The ORAC Antioxidant Chart
10. Determined a new method to establish the antioxidant capacity of extra virgin olive oil
11. Dr. William S. Gruss, M.D., Says That Medical Research Shows You Can Reduce Your Risk of Cancer By Up To 77% and Reverse the Effects of Aging in A CARDIOLOGISTS GUIDE TO ... ANTI-AGING, ANTIOXIDANTS & RESVERATROL
Post Your Comments:
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... Jobs in ... by healthcare professionals and offered by healthcare staffing agency Aureus Medical Group . ... the month of October 2015 among those searching for healthcare jobs through the company’s ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel Film Studios brings Final ... ProTrailer: Vintage. This newly styled ProTrailer pack comes with 30 all-new vintage-inspired designs, ... giving users limitless opportunities to stylize and create designs quickly and easily, all ...
(Date:11/25/2015)... ... 25, 2015 , ... Additional breast cancers found with MRI ... to a study published online in the journal Radiology. Researchers said that in ... a change in treatment. , Breast MRI is the most sensitive technique for ...
(Date:11/25/2015)... Cokato, MN (PRWEB) , ... November 25, 2015 , ... ... Thanksgiving through Christmas Eve on several models of traditional and far-infrared saunas. ... . Nordic Spruce is the most traditional Finnish sauna wood, and Finnleo uses only ...
(Date:11/25/2015)... , ... November 25, 2015 , ... Dr. John Pierce, ... learn more about hair loss treatment with the Capillus272™ Pro laser therapy cap. FDA ... for thicker and fuller hair, without the need for surgery, prescription pills, or topical ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ... the "2016 Future Horizons and Growth Strategies ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> --> This ... the Japanese therapeutic drug monitoring market, including emerging ...
(Date:11/26/2015)... 26, 2015 ... "2016 Future Horizons and Growth Strategies ... Market: Supplier Shares, Country Segment Forecasts, Competitive ... offering. --> ) has ... Future Horizons and Growth Strategies in the ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Therapeutic Drug Monitoring ... Forecasts, Competitive Intelligence, Emerging Opportunities"  report ... ) has announced the addition ...
Breaking Medicine Technology: