Navigation Links
Two Antioxidant Vitamins Don't Protect Against Heart Disease
Date:11/11/2008

Study highlights:

- A major long-term study of more than 14,000 physicians showed no cardiovascular protection from two antioxidant vitamins taken by much of the American population.

- Taken individually, vitamins E and C failed to protect against heart and blood vessel disease.

NEW ORLEANS, Nov. 11 /PRNewswire-USNewswire/ -- Vitamins E and C -- antioxidant supplements taken by many American adults -- don't protect against cardiovascular disease when taken individually, according to a long-term study of more than 14,000 male physicians presented at the American Heart Association's Scientific Sessions 2008. Results of the Physician's Health Study II (PHS II) were presented as a late-breaking clinical trial. The study was simultaneously published in the Journal of the American Medical Association.

"We found no compelling evidence that either individual vitamin E or vitamin C reduces the risk of cardiovascular disease," said J. Michael Gaziano, M.D., M.P.H., principal investigator of the study and a cardiologist at Brigham and Women's Hospital and VA Boston Healthcare System in Boston, Mass.

Gaziano said results of the study add to the growing consensus about vitamin E's lack of cardiovascular protection based on several earlier trials that failed to find any effect.

The randomized, double-blind, placebo-controlled trial included 14,641 U.S. physicians 50 and older. Cardiovascular disease in the study included nonfatal heart attack, nonfatal stroke and fatal cardiovascular disease

"This is one of the first large-scale, long-term clinical trials of individual vitamin C supplementation in the prevention of cardiovascular disease," said Howard D. Sesso, Sc.D., M.P.H., co-author and project director of PHS II and assistant professor of medicine at Brigham and Women's Hospital.

Unlike several earlier studies in which vitamins E and C were often given as part of an antioxidant cocktail, this study investigated the two vitamins individually, he said.

The findings are an example of the importance of randomized clinical trials to test promising hypotheses generated by laboratory or observational research, Sesso said. Antioxidant vitamins appeared promising in previous laboratory research and in observational human studies, in which people who reported eating a diet rich in vitamins E and C seemed to have fewer cardiovascular problems.

Fruits and vegetables may provide some protective effect beyond the vitamins they contain, or it could be that people who report eating a lot of fruits and vegetables have other characteristics that lead to better health, Sesso said.

Therefore, researchers needed a large, well-designed, placebo-controlled clinical trial -- one that included a dedicated group of participants.

Each year, the investigators mailed participants calendar packs containing each vitamin or its placebo, depending upon the group to which each physician had been randomly assigned. The doses used in the study (400 international units of vitamin E every other day and 500 milligrams of vitamin C daily) correspond to typical amounts available commercially, Gaziano said.

During an average eight years of follow-up, participants provided annual updates on compliance, various risk factors and health outcomes, allowing the investigators access to their medical records when necessary to confirm cardiovascular events or cause of death.

"Broadly speaking, there has been great interest in antioxidants in the prevention of cardiovascular disease," said Sesso. "Despite promising findings from laboratory research and observational studies, our results from PHS II point to the need for large-scale, long-term clinical trials testing the antioxidant hypothesis."

The final arm of PHS II, testing daily multivitamin supplementation, is ongoing.

Individual author disclosures are available on the abstract.

The study was funded by grants from the National Institutes of Health in Bethesda, Md., and an investigator-initiated grant from BASF Corporation in Florham Park, N.J. BASF Corporation, Wyeth Pharmaceuticals in Madison, N.J., and DSM Nutritional Products, Inc., formerly Roche Vitamins, in Parsippany, N.J., provided study agents and packaging.

Statements and conclusions of study authors that are presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http://www.americanheart.org/corporatefunding.


'/>"/>
SOURCE American Heart Association
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Susan Lark, MD Develops a Powerful ORAC Drink Packed with the Antioxidant Power of Nine Fruits
2. Too Much Sun, Too Few Antioxidants Spell Eye Trouble
3. Sunlight exposure plus low antioxidant levels may place older adults at risk for eye disease
4. Antioxidant-Rich Diet May Protect Against Eye Disease
5. Green Tea Antioxidant May Help Prevent Alzheimers
6. Antioxidant supplements may lessen benefit of radiation and chemotherapy
7. Cancer Patients Should Steer Clear of Antioxidants
8. New Antioxidant Drug Shows Promise Against Diabetes
9. Blueberry Juice Tops The ORAC Antioxidant Chart
10. Determined a new method to establish the antioxidant capacity of extra virgin olive oil
11. Dr. William S. Gruss, M.D., Says That Medical Research Shows You Can Reduce Your Risk of Cancer By Up To 77% and Reverse the Effects of Aging in A CARDIOLOGISTS GUIDE TO ... ANTI-AGING, ANTIOXIDANTS & RESVERATROL
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... feeding the Frederick area economy by obtaining investment capital for emerging technology companies. ... 2½ years that have already resulted in more than a million dollars of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia ... the company,s second affiliate in Latin America . ... ... Farma Colombia ... ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
(Date:6/23/2016)... June 23, 2016 The Biotechnology ... continues to present great opportunities to investors. Stock-Callers.com assesses ... Intrexon Corp. (NYSE: XON ), Vertex Pharmaceuticals ... (NASDAQ: ARNA ), and Regeneron Pharmaceuticals Inc. ... stocks and receive your complimentary trade alerts at: ...
Breaking Medicine Technology: