Navigation Links
Tweaking gene expression to repair lungs
Date:2/25/2013

PHILADELPHIA Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are on the rise, according to the American Lung Association and the National Institutes of Health.

These ailments are chronic, affect the small airways of the lung, and are thought to involve an injury-repair cycle that leads to the breakdown of normal airway structure and function. For now, drugs for COPD treat only the symptoms.

"A healthy lung has some capacity to regenerate itself like the liver," notes Ed Morrisey, Ph.D., professor of Medicine and Cell and Developmental Biology and the scientific director of the Penn Institute for Regenerative Medicine in the Perelman School of Medicine, University of Pennsylvania. "In COPD, these reparative mechanisms fail."

Morrisey is looking at how epigenetics controls lung repair and regeneration. Epigenetics involves chemical modifications to DNA and its supporting proteins that affect gene expression. Previous studies found that smokers with COPD had the most significant decrease in one of the enzymes controlling these modifications, called HDAC2.

"HDAC therapies may be useful for COPD, as well as other airway diseases," he explains. "The levels of HDAC2 expression and its activity are greatly reduced in COPD patients. We believe that decreased HDAC activity may impair the ability of the lung epithelium to regenerate."

Using genetic and pharmacological approaches, they showed that development of progenitor cells in the lung is specifically regulated by the combined function of two highly related HDACs, HDAC/1 and /2. Morrisey and colleagues published their findings in this week's issue of Developmental Cell.

By studying how HDAC activity, as well as other epigenetic regulators, controls lung development and regeneration, they hope to develop new therapies to alleviate the unmet needs of patients with asthma and COPD.

HDAC1/2 deficiency leads to a loss
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Synthetic circuit allows dialing gene expression up or down in human cells
2. Gene expression improves the definition of a breast cancer subtype
3. Gene expression test identifies low-risk thyroid nodules
4. Overexpression of proteins 14-3-3 related to chemotherapy resistance
5. Control of gene expression: Histone occupancy in your genome
6. Changes in gene expression may help explain high blood pressure in pregnancy
7. Injected Hydrogel May Help Repair Failing Hearts
8. US Drug Watchdog Now Urges Victims Of A Transvaginal Mesh, Tape Or Sling Repair Surgery That Failed To Call Them For The Names Of The Best Possible Women Lawyers
9. US Drug Watchdog Now Urges Victims of a Transvaginal Mesh Product Failure to Call Them for the Names of Top Women Attorneys - Especially if They had a Failed Repair Surgery
10. Mussel-inspired glue for surgical repair and cancer drug delivery
11. US Drug Watchdog Now Urges Transvaginal Mesh Failure Victims Who Have Had an Unsuccessful Repair Surgery to Call Them for the Names and Contacts of the Best Women Lawyers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tweaking gene expression to repair lungs
(Date:12/26/2014)... DW-InductionHeating.com (DaWei Induction Heating Co.) is a comprehensive high-tech ... marketing of a series of induction heating equipment. Today, ... of induction brazing equipments . , According to ... refers to the joining of two or more ... manager says that there are fundamental differences in the ...
(Date:12/25/2014)... December 26, 2014 The report ... to 2023” focuses on the current treatment landscape, ... the colorectal cancer market. Stivarga is a drug ... or rectal cancer. Boehringer Ingelheim is developing nintedanib ... treatment of refractory CRC in the US, Europe, ...
(Date:12/25/2014)... 26, 2014 Recently, Dylan Queen, a ... excitedly released its collection of discounted prom dresses, most ... a senior spokesman of the company, the promotion is ... promotion is to expand the UK market. , The ... different colors, lengths, and styles: A-line strapless, empire strapless ...
(Date:12/25/2014)... When head lice hits a home or school, ... get rid of it while keeping it from taking over ... have the solution right in their neighborhood: Lice Troopers ... provides full spectrum head lice screening and treatment services to ... Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. ...
(Date:12/25/2014)... -- Among early stage breast cancer patients who undergo ... percent will eventually develop leukemia as a result of ... comes from a review of more than 20,000 breast ... suggests that the risk for developing treatment-related leukemia, though ... "The frequency of bone marrow cancers such as ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... arsenal consists of creams, facemasks and peelers in packaging that ... battle against the wrinkles that come inevitably with age has ... ,The latest weapons, however, are primed to work from ... potions designed to get under the epidermis, the outermost layer ...
... that can diagnose dengue fever in early stage was launched ... multinational manufacturer and distributor of life science research products and ... the kit helps to diagnose dengue on the first day ... ,"The test kit - the first in the Indian market ...
... call to the food and drug watchdog, The FDA, to ... This has been put forth vociferously by Editors of a ... ,A report enabled by The Institute of Medicine (IOM) ... more manpower, finance and authority to be able to conduct ...
... A "Mediterranean" diet rich in olive oil, vegetables, fruits, ... developing// Alzheimer's disease according to U.S. researchers. ,Lead ... at Columbia University Medical Center in New York said, ... with Alzheimer's disease." ,Scarmeas added that this ...
... recent study reveals that moderate intensity regular exercise can ... ,This study was published in the November ... the American Cancer Society. ,The study determined that exercise ... maintenance of red blood cells level during radiation treatment. ...
... experts announced that the term schizophrenia should be done away ... stigmatizing. ,"It is a harmful concept," said Professor ... University of Central England in Birmingham.,He added, "Symptoms such as ... the illness but may be reactions to traumatic and troubling ...
Cached Medicine News:Health News:Do Anti-wrinkle Cosmetics Really Work? 2Health News:Exercise alleviates Anemia in Breast cancer patients 2Health News:‘Schizophrenia’ term ought to be abolish 2
(Date:12/24/2014)... Dec. 24, 2014 Soligenix, Inc. (OTCQB: ... company developing products that address unmet medical needs ... announced today that on December 24, 2014 it ... The Company raised approximately $2.3 million in ... use the net proceeds from the offering to ...
(Date:12/24/2014)... Dec. 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... is proud to announce Jennifer Hagerman , Pharm.D., ... will take office as the president of the Michigan ... ceremony will take place Feb. 28, 2015, at the ... at the Renaissance Center in Detroit, Michigan ...
(Date:12/24/2014)... Dec. 23, 2014 PuraMed BioScience®, Inc., (OTC ... (OTC) medicinal and healthcare products, announced it received the ... a hemp-based, advanced headache relief product, for planned distribution ... Colorado , Washington State ... With the MigraPure H Advanced headache relief gel formulation ...
Breaking Medicine Technology:Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3
... , AURORA, Ontario, ... HXBPF) reports that at its Annual General Meeting held today, ... Directors , All seven Board members were re-elected as ... ,Donald H. Segal, Chairman of the Board and Chief Executive ...
... , , New Television Ad, " ... " Begins Airing Today , WASHINGTON, Dec. ... strategy that outlines the quality of life improvements and cost ... senior citizens and others living with limited mobility to receive ...
Cached Medicine Technology:Helix BioPharma Reports On 2009 Annual General Meeting 2Helix BioPharma Reports On 2009 Annual General Meeting 3The SCOOTER Store Launches New Advertising Highlighting the Value and Cost Savings From Medicare's Power Mobility Benefit 2
Volume range 1-5 ml. Designed for use with large laboratory vessels....
Conducting disposable tips....
... to order tips. Each box contains 1000 tips ... contains 200 tips (4 bags of 50 tips). ... 200 tips per pack. Bulk Packs are sealed ... opened for quick access to Gilsons Diamond Tips. ...
... With its wide orifice tip, the Finntip ... cell suspensions and macromolecules like genomic DNA. ... causes cell fragmentation. It is excellent for ... the model, the inside diameter of the ...
Medicine Products: