Navigation Links
Tweaking gene expression to repair lungs
Date:2/25/2013

PHILADELPHIA Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are on the rise, according to the American Lung Association and the National Institutes of Health.

These ailments are chronic, affect the small airways of the lung, and are thought to involve an injury-repair cycle that leads to the breakdown of normal airway structure and function. For now, drugs for COPD treat only the symptoms.

"A healthy lung has some capacity to regenerate itself like the liver," notes Ed Morrisey, Ph.D., professor of Medicine and Cell and Developmental Biology and the scientific director of the Penn Institute for Regenerative Medicine in the Perelman School of Medicine, University of Pennsylvania. "In COPD, these reparative mechanisms fail."

Morrisey is looking at how epigenetics controls lung repair and regeneration. Epigenetics involves chemical modifications to DNA and its supporting proteins that affect gene expression. Previous studies found that smokers with COPD had the most significant decrease in one of the enzymes controlling these modifications, called HDAC2.

"HDAC therapies may be useful for COPD, as well as other airway diseases," he explains. "The levels of HDAC2 expression and its activity are greatly reduced in COPD patients. We believe that decreased HDAC activity may impair the ability of the lung epithelium to regenerate."

Using genetic and pharmacological approaches, they showed that development of progenitor cells in the lung is specifically regulated by the combined function of two highly related HDACs, HDAC/1 and /2. Morrisey and colleagues published their findings in this week's issue of Developmental Cell.

By studying how HDAC activity, as well as other epigenetic regulators, controls lung development and regeneration, they hope to develop new therapies to alleviate the unmet needs of patients with asthma and COPD.

HDAC1/2 deficiency leads to a loss
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Synthetic circuit allows dialing gene expression up or down in human cells
2. Gene expression improves the definition of a breast cancer subtype
3. Gene expression test identifies low-risk thyroid nodules
4. Overexpression of proteins 14-3-3 related to chemotherapy resistance
5. Control of gene expression: Histone occupancy in your genome
6. Changes in gene expression may help explain high blood pressure in pregnancy
7. Injected Hydrogel May Help Repair Failing Hearts
8. US Drug Watchdog Now Urges Victims Of A Transvaginal Mesh, Tape Or Sling Repair Surgery That Failed To Call Them For The Names Of The Best Possible Women Lawyers
9. US Drug Watchdog Now Urges Victims of a Transvaginal Mesh Product Failure to Call Them for the Names of Top Women Attorneys - Especially if They had a Failed Repair Surgery
10. Mussel-inspired glue for surgical repair and cancer drug delivery
11. US Drug Watchdog Now Urges Transvaginal Mesh Failure Victims Who Have Had an Unsuccessful Repair Surgery to Call Them for the Names and Contacts of the Best Women Lawyers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tweaking gene expression to repair lungs
(Date:4/17/2014)... identified the first genetic variant specifically associated with ... for around 10-15 per cent of all breast ... the breast cancer sub-type, called invasive lobular carcinoma, ... of this particular kind of breast cancer, which ... published today (Thursday) in the journal PloS ...
(Date:4/17/2014)... PLOS Pathogens , children who live in regions of ... immune response to infection with malaria parasites that may ... and illness and partially control the growth of malaria ... develop future interventions that prevent or mitigate the disease ... 200 million cases of malaria occur worldwide, resulting in ...
(Date:4/17/2014)... 17, 2014) Two recent papers by a ... colleagues may help scientists develop treatments or vaccines ... Japanese encephalitis and other disease-causing flaviviruses. , Jeffrey ... molecular genetics at the School of Medicine and ... Medical Institute, and colleagues recently published articles in ...
(Date:4/17/2014)... team has created a new technology for modifying ... travel the body and selectively target cancer and ... devices that monitor and modify human physiology is ... no existing technology enabled bioengineers to build such ... respond in a customized fashion. , "The project ...
(Date:4/17/2014)... It,s estimated that as many as 10 million older ... of loneliness and isolation. , However, new research ... retired older Americans for six years found that ... of depression by more than 30 percent. , "That,s ... State University professor of telecommunication, information studies and media ...
Breaking Medicine News(10 mins):Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:CU researchers discover target for treating dengue fever 2Health News:Building 'smart' cell-based therapies 2Health News:Internet use can help ward off depression among elderly 2
... alcohol consumption and cigarette smoking were associated with increased ... Coffee drinking and physical inactivity were associated specifically with ... modifiable risk factors for different types of headaches in ... , a journal published by Wiley-Blackwell on behalf of ...
... Public Health (HSPH) have found that children and adolescents ... smoke-free public places have significantly lower levels of a ... in counties with no smoke-free laws. The children ... laws had 39% lower prevalence of cotinine in their ...
... Lngstrm, Ph.D., a professor in the department of biochemistry ... been named as this year,s recipient of the Georg ... to the nuclear medicine profession. Lngstrm was presented the ... 57th Annual Meeting, June 5𔃇, in Salt Lake City, ...
... Team Xtreme and 4B organize ... the charities of Live and Cudeca. , ... (PRWEB) June 5, 2010 -- On June 26th the outdoor adventure sports company Team Xtreme, that ... in Seville. , , ,The collected funds will go to the L.I.V.E. foundation ( a charity ...
... CHICAGO, June 5 The combination of two different ... liver cancers is not effective against advanced melanoma, according ... the 46th annual meeting of the American Society of ... study, we learn something important about the treatment of ...
... ... surgery can now be certain that a less-invasive technique called sentinel node ... removing all lymph nodes from the underarm area, according to a new ... meeting by oncologists from the National Surgical Adjuvant Breast and Bowel Project ...
Cached Medicine News:Health News:Alcohol use and smoking are associated with headaches in high schoolers 2Health News:Smoke-free air laws effective at protecting children from secondhand smoke 2Health News:Bengt Roland Långström receives SNM's 2010 Georg Charles de Hevesy Nuclear Pioneer Award 2Health News:Combination treatment regimen not effective against advanced melanoma 2Health News:Less-invasive Lymph Node Resection Following Breast Cancer Surgery Confirmed as Standard of Care in Eight-year Study Led by AGH Doctors 2
(Date:1/15/2014)... 2014  In an unprecedented effort to curb the spread of "superbugs" ... transport vehicles, an advanced and portable UV germicidal lamp manufactured by ... time. In order to prevent EMS paramedics and ... West Palm Beach Fire Rescue is the first ...
(Date:1/15/2014)... The Cadence Fitness & Health Center has been ... Fitness Association, a non-profit organization assisting medically integrated health ... Cadence Fitness & Health Center is the only certified ... the Chicagoland area. "The certification means the ...
(Date:1/15/2014)... 2014  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 ... by its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ("Purchaser"), ... of Solta Medical, Inc. (NASDAQ: SLTM ) ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
For restriction digests, immuno-precipitations, enzyme assays, TLC spotting and others...
The Ultra Micro tip for the Eppendorf and Nichiryo/BenchMate 0.5-10 L pipettors is perfect for working with low volume samples....
... way to order tips. Each box contains 1000 ... which contains 200 tips (4 bags of 50 ... of 200 tips per pack. Bulk Packs are ... be opened for quick access to Gilsons Diamond ...
... economical way to order tips. Each box ... tips). Also available in easy-to-open, re-sealable Bulk ... Packs are sealed with a tamper-proof strip ... access to Gilsons Diamond Tips. Bulk Packs ...
Medicine Products: