Navigation Links
Tweaking gene expression to repair lungs
Date:2/25/2013

PHILADELPHIA Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are on the rise, according to the American Lung Association and the National Institutes of Health.

These ailments are chronic, affect the small airways of the lung, and are thought to involve an injury-repair cycle that leads to the breakdown of normal airway structure and function. For now, drugs for COPD treat only the symptoms.

"A healthy lung has some capacity to regenerate itself like the liver," notes Ed Morrisey, Ph.D., professor of Medicine and Cell and Developmental Biology and the scientific director of the Penn Institute for Regenerative Medicine in the Perelman School of Medicine, University of Pennsylvania. "In COPD, these reparative mechanisms fail."

Morrisey is looking at how epigenetics controls lung repair and regeneration. Epigenetics involves chemical modifications to DNA and its supporting proteins that affect gene expression. Previous studies found that smokers with COPD had the most significant decrease in one of the enzymes controlling these modifications, called HDAC2.

"HDAC therapies may be useful for COPD, as well as other airway diseases," he explains. "The levels of HDAC2 expression and its activity are greatly reduced in COPD patients. We believe that decreased HDAC activity may impair the ability of the lung epithelium to regenerate."

Using genetic and pharmacological approaches, they showed that development of progenitor cells in the lung is specifically regulated by the combined function of two highly related HDACs, HDAC/1 and /2. Morrisey and colleagues published their findings in this week's issue of Developmental Cell.

By studying how HDAC activity, as well as other epigenetic regulators, controls lung development and regeneration, they hope to develop new therapies to alleviate the unmet needs of patients with asthma and COPD.

HDAC1/2 deficiency leads to a loss
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Synthetic circuit allows dialing gene expression up or down in human cells
2. Gene expression improves the definition of a breast cancer subtype
3. Gene expression test identifies low-risk thyroid nodules
4. Overexpression of proteins 14-3-3 related to chemotherapy resistance
5. Control of gene expression: Histone occupancy in your genome
6. Changes in gene expression may help explain high blood pressure in pregnancy
7. Injected Hydrogel May Help Repair Failing Hearts
8. US Drug Watchdog Now Urges Victims Of A Transvaginal Mesh, Tape Or Sling Repair Surgery That Failed To Call Them For The Names Of The Best Possible Women Lawyers
9. US Drug Watchdog Now Urges Victims of a Transvaginal Mesh Product Failure to Call Them for the Names of Top Women Attorneys - Especially if They had a Failed Repair Surgery
10. Mussel-inspired glue for surgical repair and cancer drug delivery
11. US Drug Watchdog Now Urges Transvaginal Mesh Failure Victims Who Have Had an Unsuccessful Repair Surgery to Call Them for the Names and Contacts of the Best Women Lawyers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tweaking gene expression to repair lungs
(Date:8/22/2014)... 2014 With the stage set for ... Store Expo - which will be held in Boston ... op-ed in its online opinion section, Podium. The ... is co-authored by Steven C. Anderson, IOM, CAE, president ... of the MCPHS University School of Pharmacy – Worcester/Manchester. ...
(Date:8/22/2014)... Norton HealthDay Reporter ... number of Americans on work disability chronically use powerful ... found that between 2007 and 2011, about 44 percent ... prescribed narcotic painkillers each year. And the percentage using ... to 23 percent in 2011. Experts said ...
(Date:8/22/2014)... Millennium Treatment Group, a drug ... recently launched a new website. Patients, parents, loved ... now find Millennium Treatment Group at http://www.millenniumtreatmentgroup.com ... at the beginning of July. Everything anyone would ... found on the website. There’s an About Us ...
(Date:8/22/2014)... time an oncogenic somatic mutation at amino acid 918 ... identified in small cell lung cancer (SCLC) tumors and ... produced increased intracellular signaling and cell growth. , SCLC ... 15% of all lung cancers and is strongly associated ... has been extensively examined for genomic alterations and targeted ...
(Date:8/22/2014)... Advancements in ultrasound technologies make ... due to their cost-effectiveness, non-invasiveness, and absence of ... such as the evolution of wireless transducers and ... market moving throughout 2014 and beyond. Such Ultrasound’s ... only the point-of-care (POC) testing in hospital settings, ...
Breaking Medicine News(10 mins):Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 2Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 3Health News:Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds 2Health News:Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds 3Health News:Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds 4Health News:Millennium Treatment Group Has a New Website 2Health News:Novel oncogenic RET mutation found in small cell lung cancer 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 3
... Some 19 percent of soldiers returning from Iraq ... percent. While prevalence of migraine among the U.S. ... sleep quality in soldiers with chronic headaches including post-traumatic ... Madigan Army Medical Center in Tacoma, WA presenting at ...
... the American Headache Society,s 52nd Annual Scientific Meeting in Los ... leads to changes in the levels of key proteins that ... Paul L. Dunham, Ph.D. and his team at Missouri ... understand the mechanisms by which sleep disturbance increases the risk ...
... mobile phone base station during pregnancy, says study A ... Great Britain has found no association between a mother living near ... risk of that child developing cancer before reaching the age of ... is the first to look at the health effects of mobile ...
... in the department of physics at NJIT, will lead ... (NRC) of the National Academies ( www.nationalacademies.org ) to ... the aftermath of Toyota,s large recalls. The group, which ... 1, 2010 in Washington, DC, includes notable engineers, scientists ...
... 3rd party website ... rid of love handles , ... 2010 -- The newest recent launch of a fitness sites on how to get a six ... be achieved with the aid of supplements. Getting a perfectly toned muscular body with defined six ...
... high-calorie food more , TUESDAY, June 22 (HealthDay News) -- ... high-calorie snacks. Yet, your eyes keep straying toward that box ... restrain your impulse to inhale them. , Such a pill ... presented Tuesday at the Endocrine Society,s annual meeting in San ...
Cached Medicine News:Health News:No link between early childhood cancers and living near mobile phone base station during pregnancy, says study 2Health News:No link between early childhood cancers and living near mobile phone base station during pregnancy, says study 3Health News:NJIT professor heads panel studying sudden car acceleration 2Health News:How To Get A Six Pack: Site Reveals How You Can Trade In Six-Pack Of Beer For Six-Pack Abs 2Health News:Hormone Raises Desire for Fattening Foods 2Health News:Hormone Raises Desire for Fattening Foods 3
(Date:8/22/2014)... DUBLIN, Ireland , August 22, 2014 ... ,Research and Markets ( http://www.researchandmarkets.com/research/x34qgv/global_laboratory ) has announced ... Balance Market 2014-2018"  report to their offering.  ... electronic balance is an essential instrument for ... in the precise weighing of materials. It ...
(Date:8/22/2014)... , Aug. 22, 2014  As the Medical Affairs, ... many leaders in this area are exploring methods to ... The Medical Affairs Consortium at Best Practices, LLC is ... sharing insights about the key challenges they face. The ... solutions through three virtual roundtable discussions where leaders discuss ...
(Date:8/22/2014)... Aug. 22, 2014 MC Medical, a subsidiary of ... Columbus, OH medical device company, have ... laparoscopic and robotic visualization system in Japan ... sale in Japan in the latter ... and an extensive product portfolio in endoscopic surgery market in ...
Breaking Medicine Technology:Global Laboratory Electronic Balance Market 2014-2018: Key Vendors are A&D Company, Mettler-Toledo, Sartorius and Thermo Fisher 2Best Practices' Medical Affairs Consortium Survey Has Achieved Strong Participation 2MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: