Navigation Links
Turning up the heat to kill cancer cells: The 'Lance Armstrong effect'
Date:10/19/2011

The "Lance Armstrong effect" could become a powerful new weapon to fight cancer cells that develop resistance to chemotherapy, radiation and other treatments, scientists say in a report in the ACS journal Molecular Pharmaceutics.

Robert Getzenberg and Donald Coffey explain that many advances have occurred in the 40 years since President Nixon declared a "War on Cancer" on December 23, 1971. However, cancer remains a leading cause of death worldwide, claiming almost 8 million lives annually. Patients with some forms of cancer respond well to treatment, while others have disease that becomes resistant to every known treatment. Patients with testicular cancer have a high survival rate more than 70 percent even if the cancer metastasizes, or spreads. For example, Lance Armstrong, the famous cyclist, beat metastatic testicular cancer that spread to his lungs and brain, and then went on to win the Tour de France a record seven consecutive times. But patients with pancreatic cancer have only a 25 percent survival rate in the first year and a 6 percent survival rate by the fifth year after diagnosis. Why is this?

Getzenberg and Coffey realized that the microenvironment of testicular cancer cells was a little different. Testicles are usually several degrees cooler than the rest of the body, owing to their position outside the body. When cancer cells from the testicles spread to other organs, such as the lungs or brain, they encounter a warmer environment. The researchers propose that this warmth shocks the tumor cells, making them more susceptible to conventional cancer therapies, which leads to a higher survival rate among testicular cancer patients. This is the so-called "Lance Armstrong effect." The researchers describe tests now underway on nanoparticle therapies to specifically heat other types of tumors above their normal temperatures to see whether this effect holds true for non-testicular cancers.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related medicine news :

1. Doctors Turning to Cardiac Catheterization Too Quickly
2. New iVillage Study Reveals That Majority of Women 18-34 Go Online First With Health Questions - Before Turning to Their Doctor or Other Family Members
3. Parents of Autistic Children Turning to Alternative Treatments
4. Holistic Management and Allan Savory Win the 2010 Buckminster Fuller Award for Turning Deserts into Thriving Grasslands and Combating Climate Change.
5. Turning a painkiller into a cancer killer
6. Study Probes Causes of Anger in Returning U.S. Soldiers
7. Turning back the cellular clock
8. Microbicide trial results a turning point for HIV prevention, says team testing same gel
9. Gene identified that prevents stem cells from turning cancerous
10. Turning off stress
11. Innovative virtual reality exposure therapy shows promise for returning troops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... Presence Technology ... has been included by Gartner, Inc. in the Contact Center Infrastructure Magic Quadrant ... Center Infrastructure technologies, some of which include: Computer-telephony integration (CTI)/Web services interfaces, ...
(Date:5/31/2016)... Beach, Florida (PRWEB) , ... May 31, 2016 ... ... to Jay Butch of CertainTeed Corporation, he knew it was something that contractors ... as state-of-the-art and cutting-edge as it gets,” says Butch, CertainTeed’s Director of Contractor ...
(Date:5/31/2016)... Switzerland (PRWEB) , ... May 31, 2016 , ... The ... this model in their laboratories as well. However, laboratories have different challenges compared to ... benefits of lean operations in the lab, METTLER TOLEDO has developed the Lean ...
(Date:5/31/2016)... ... 2016 , ... Spectrum Aquatics has launched a brand new ADA pool lift, ... with the user in mind. , “Over the last two years our key customers ... 400 lbs lift is a necessary requirement for certain facilities with specific needs,” said ...
(Date:5/31/2016)... ... ... a recent interview on The Greenburgh Report radio show hosted by Greenburgh, NY Town ... leading medical insurance advocate Adria Goldman Gross discussed several eye-opening issues that have combined ... the interview with Mr. Feiner that aired on May 7, 2016, Ms. Gross, the ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... 30, 2016 According ... Biometrics Market by Technology (Single-factor (Fingerprint, Face, ... Application (Workforce Management), End User (Hospitals, Healthcare ... by MarketsandMarkets, the market is projected to ... USD 1,182.6 Million by 2016, at a ...
(Date:5/30/2016)... - DCGI grants limited approval to market Stempeucel® product for ... Stempeucel® becomes 5th off-the-shelf Stem cell product to be approved by ... Disease (also known as Thromboangiitis Obliterans) is a major unmet medical ... - Prevalence of Buerger,s Disease is estimated to be 1,000,000 in ... the European Community & USA ...
(Date:5/27/2016)... LabStyle Innovations Corp . ( ... today announced that the Company,s Chief Financial Officer, Zvi ... held June 1-2 in New York, NY ... in Los Angeles, CA. ... operational milestones, including the U.S. FDA Clearance and commercial launch ...
Breaking Medicine Technology: