Navigation Links
Turning down gene expression promotes nerve cell maintenance
Date:2/1/2009

February 2, 2009, Cambridge, UK Anyone with a sweet tooth knows that too much of a good thing can lead to negative consequences. The same can be said about the signals that help maintain nerve cells, as demonstrated in a new study of myelin, a protein key to efficient neuronal transmission.

Normal nerve cells have a myelin sheath, which, much like the insulation on a cable, allows for rapid and efficient signal conduction. However, in several diseases the most well-known being multiple sclerosis demyelination processes cause the breakdown of this "insulation", and lead to deficits in perception, movement, cognition, etc. Thus, in order to help patients of demyelinating disease, researchers are studying the pathways that control myelin formation and maintenance.

A new study by University of California scientists examines the role of a structural protein, called lamin, in maintaining myelin. They found that, while lamin is necessary in the initial stages of myelin formation, too much lamin promotes myelin breakdown. Further investigation led the researchers to the discovery of a signal that fine-tunes lamin expression. This signal, a microRNA called miR-23, can turn down lamin gene expression, and thereby prevent demyelination due to lamin overexpression.

This new work reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, adds another piece to the puzzle that is understanding myelin formation and maintenance. Additionally, the identification of miR-23 as a myelin regulator introduces a new potential drug target in developing treatments for demyelinating illness.


'/>"/>

Contact: Donna Perry
donna@biologists.com
44-012-234-33319
The Company of Biologists
Source:Eurekalert

Page: 1

Related medicine news :

1. Depression Taking Toll on Returning U.S. Vets
2. Returning Troops Get Help for PTSD
3. Easter Seals Launches Program for Veterans Returning from Iraq and Afghanistan with Traumatic Brain Injuries
4. Lilly Grant to VA Will Enhance Services for Returning Combat Veterans
5. Capsule endoscopy turning up undiagnosed cases of Crohns disease
6. Remarks by President Bush, Senator Bob Dole and Secretary Donna Shalala on Commission on Care for Americas Returning Wounded Warriors Report Implementation
7. Turning Pointe Therapeutic Riding Recognized for Excellence in Providing Equine-Assisted Therapies to People with Disabilities
8. Non-Profit Calls on Mental Health Professionals to Honor Veterans Day by Giving an Hour of Free Counseling to Returning Veterans
9. VH1 Set to Continue Its Record-Breaking Pace Into 2008 with Brand New Premieres and Returning Series
10. USA TODAY to Report Special Series "Turning 62: The Retirement Boom Begins"
11. Turning on adult stem cells may help repair bone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... taken by Firestone officials at the company,s rubber ... spread of the disease there and could prove effective ... provides health services to about 80,000 employees, retirees, their ... Between Aug. 1 and Sept. 23, there were 71 ... That incidence rate of 0.09 percent was much lower ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... who was diagnosed with Ebola while working for NBC News ... can leave the special isolation unit at Nebraska Medical Center in ... the hospital said Tuesday. A blood test confirmed by the ... 33, can head home to Providence, R.I., NBC News ...
(Date:10/20/2014)... Orlando, Florida (PRWEB) October 20, 2014 ... fired-up former Gov. Charlie Crist made a brief fundraising ...  in Orlando on Thursday. , Fresh from a debate ... refused to take the stage for the first seven ... podium, the former governor described the incident in one ...
(Date:10/20/2014)... Wakefield, MA (PRWEB) October 20, 2014 ... be sponsoring a booth at the American Foundation for ... October 25th. The AFSP is a not-for-profit organization that ... year. Net proceeds from these events are used to ... research, but education and personal relationships as well. ...
(Date:10/20/2014)... 2014 Women’s health specialist, Dr. Amber ... Gynecology of Columbus, Inc., A Division of MaternOhio Clinical ... more than 100,000 patients annually. Dr. Murphy will provide ... stages of a women’s life. She is accepting new ... Westerville and Dublin. , Dr. Murphy offers a wide ...
Breaking Medicine News(10 mins):Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3
... blood pressure is well known, however// a new study reports ... published today in the Open Access journal Environmental Health for ... of salt particles can have just the same effect on ... an occupational health hazard for workers in salt factory. It ...
... Authority (NPPA) has been working// on bringing down the ... the manufacturers and has finally succeeded. According to NPPA ... bring about a price reduction ranging between 2.14% to ... hearing to explain the reasons for steep price increase ...
... Gengraine Technologies (Avesthagen) of India is collaborating// with ... Developing Countries (IFU) of Germany for Osteoporosis research. ... euro. Avesthagen said “"The alliance will cover diagnosis, ... disorders.” The research studies related to menopause linked ...
... patients with diastolic heart failure increases// the survival rate ... ,William C. Little and his research team from ... heart failure (DHF) treated with statins has better survival ... failure patients published in the Journal Circulation: Journal of ...
... For the elderly population, adjusting to the raising temperatures// in ... heat that may affect the elderly people are heat exhaustion ... Health Letter from the Harvard Medical School had given some ... a little easier during the summers. ,In addition to ...
... article reviewing the research carried out so far into the ... revealed that a new phase III trial is scheduled to ... CoQ10 has escalated, causing soaring prices and reports of fake ... to have been triggered by the publication of Shults’ earlier ...
Cached Medicine News:Health News:Hypertension can be caused by Inhalation of Salt 2Health News:Hypertension can be caused by Inhalation of Salt 3Health News:Statins Gives New Hope for Increased Survival Rate of Heart Failure Patients 2Health News:Elderly People Needs To Tackle The Heat Effectively 2Health News:New Study to look at the Beneficial Effects of Coenzyme Q10 on Parkinson’s disease 2
(Date:10/22/2014)... Oct. 22, 2014   Reproductive Medicine Associates ... in the field of infertility, presents new clinical ... screening. The research abstract, released during the 70 ... (ASRM) meeting in Honolulu, Hawaii ... gene defect (SGD) pre-implantation genetic diagnosis (PGD). ...
(Date:10/22/2014)... Oct. 22, 2014 AVACEN Medical announced today ... 510 (k) OTC clearance by the U.S. Food and ... be marketed over the Internet for: the temporary ... and minor strains and sprains . Logo ... 100 (MSRP $2495) is a sophisticated medical device incorporating ...
(Date:10/22/2014)... 22, 2014  With a vision to ensure ... a Global Pharmaceutical and Biotech manufacturer selects and ... turnkey solution to protect their animal health brand.  ... Photo - http://photos.prnewswire.com/prnh/20141021/153439 ... and aggregated by the Xyntek and Antares solution ...
Breaking Medicine Technology:New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2Xyntek and Antares Serialization Solution Protects Pets Too! 2
... GRONINGEN, The Netherlands , June ... Netherlands , announced this week that in collaboration,with the ... obtained outstanding,results for the treatment of inhalation anthrax. In ... with extended time to treatment (48h post,infection) with a ...
... , June 21 Emdeon Inc. (NYSE: ... management solutions, today announced the acquisition of Chapin Revenue Cycle Management, ... leading technology-enabled provider of hospital-based revenue cycle services including accounts receivable ... , , ...
Cached Medicine Technology:Survival Rate Up to 100% for Late Stage Treatment of Anthrax Infections 2Emdeon Acquires Chapin to Enhance Provider-Focused Payment Integrity 2Emdeon Acquires Chapin to Enhance Provider-Focused Payment Integrity 3Emdeon Acquires Chapin to Enhance Provider-Focused Payment Integrity 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: