Navigation Links
Turning back the clock on aging muscles?
Date:2/20/2014

A study co-published in Nature Medicine this week by University of Toronto researcher Penney Gilbert has determined a stem cell based method for restoring strength to damaged skeletal muscles of the elderly.

Skeletal muscles are some of the most important muscles in the body, supporting functions such as sitting, standing, blinking and swallowing. In aging individuals, the function of these muscles significantly decreases.

"You lose fifteen percent of muscle mass every single year after the age of 75, a trend that is irreversible," cites Gilbert, Assistant Professor at the Institute of Biomaterials & Biomedical Engineering (IBBME) and the Donnelly Centre for Cellular & Biomolecular Research (CCBR). The study originates from Gilbert's postdoctoral research at Stanford University's Baxter Laboratory for Stem Cell Biology.

Through tracing the signaling pathways of the cells, the researchers including lead author, Professor Helen Blau, and postdoctoral researcher Ben Cosgrove determined that during aging, a subpopulation of stem cells begin to express a modification of a protein that inhibits their ability to grow and make new stem cells.

"But if we instead treated those cells outside the body with a drug that prevented that protein modification from occurring, in combination with culturing the cells on something soft that is reminiscent of soft skeletal tissue, like a hydrogel biomaterial, the combination allowed the aged cells to grow and make more copies of themselves," Gilbert describes.

The rejuvenated cell cultures were then transplanted into injured and aged tissues, with remarkable results: the transplanted cells returned strength to the damaged and aged tissues to levels matching a young, healthy state.

"We've now shown that muscle stem cells progressively lose their stem cell function during aging," Cosgrove said in a statement. "This treatment does not turn the clock back on

d
'/>"/>

Contact: Erin Vollick
comm.ibbme@utoronto.ca
416-946-8019
University of Toronto
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Turning autism upside down: When symptoms are strengths
2. Turning Stone’s Skaná Spa Honored by SpaFinder Readers as Top Casino Spa and Top Spa for Golf
3. Agein Corporation, a Leading Anti-Aging Company, Responds to Research Showing More Men Turning to Cosmetic Surgery to Increase Work Opportunities
4. TurningPoint Appraised at CMMI Level 3 for Services
5. FlipHTML5.com Now Offers A New Page Turning Maker Software
6. TurningPoint Ranks No. 1605 on the 2013 Inc. 500
7. 5000 With Three-Year Sales Growth of 247%
8. Narconon Freedom Center Celebrates Eight Years Turning Hopeless Into Dopeless
9. Scott Sheldon Introduces Point of View Series; Turning Heads and Giving You "Piece of Mind"
10. Newly Released Parenting Upward Guide: Crafted for the Adult Children of the 10,000 Baby Boomers Turning 65 Every Day
11. Could turning on a gene prevent diabetes?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Turning back the clock on aging muscles?
(Date:10/22/2014)... 22, 2014 Shriners Hospitals for Children® ... change the current location of Shriners Hospitals for Children ... across from the University of Kentucky Albert B. Chandler ... care center, owned and operated by Shriners Hospitals for ... of children and their families well into the future. ...
(Date:10/22/2014)... 22, 2014 During the Western United ... supply runs dangerously low, Southern Oregon’s water is proving ... despite the lowest mountain snow pack on record in ... and early autumn.* That was the observation of journalist-hikers ... book “Hiking Southern Oregon,” during an interview with water ...
(Date:10/22/2014)... only 24 hours in a day, that doesn’t seem to be ... their busy schedules for exercise and fitness. Fortunately, one does not ... shape. Here are five ways you can reach your fitness and ... Commute , Consider riding a bike or taking the bus or ... If you must use your car to get to work, start ...
(Date:10/22/2014)... Steven Reinberg HealthDay ... Infants who quickly add weight and length may be showing ... suggests. In adults, certain genes have been linked to ... proportionate gains in fat and lean muscle, the researchers said. ... heavier and taller. By ages 2 and 3, however, these ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... of conventional in vitro fertilization (IVF) -- the incubation of ... in a device inside the vagina, new research suggests. ... device, called an INVOcell, might sharply cut costs for pricey ... technology more accessible to those who don,t live near big-city ...
Breaking Medicine News(10 mins):Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4
... Kendle (Nasdaq: KNDL ) a,leading, global full-service ... full year 2008. , (Logo: ... The Company now expects full year 2008 net ... to $480 million, down from the previous range of ...
... Twenty-two location cardiovascular group practice to use Sage ... and position itself for pay-for-performanceTAMPA, Fla., Jan. 12 ... Institute, a Saginaw-Mich.-based group practice including 33 nationally ... selected the integrated Sage Intergy practice management (PM) ...
... Assurance Determines Health Services are GoodVIRGINIA BEACH, Va., ... AGP ) today announced that its wholly ... been awarded New Health Plan Accreditation by the ... it offers high-quality health services to its 56,000 ...
... -- Mindray Medical,International Limited (NYSE: MR ... devices worldwide, today announced selected preliminary,unaudited results for ... The,preliminary results reported below include the results of ... ("DPM") starting from May,1, 2008. , ...
... Share Latest Breast Cancer Information at the Only International Conference ... An expected 800 young breast cancer survivors, caregivers and medical ... on breast cancer in pre-menopausal women from some of the ... Conference for Young Women Affected by Breast Cance r ...
... Align Technology,Inc. (Nasdaq: ALGN ) today ... cleared new labeling for the Invisalign system, thereby removing ... In addition,certain conditions previously listed as contraindications will now ... the years, our customers have demonstrated that many different ...
Cached Medicine News:Health News:Kendle Revises Full Year 2008 Guidance 2Health News:Michigan CardioVascular Institute Selects Sage Intergy EHR to Streamline Clinical, Workflow and Reporting Efficiencies 2Health News:Michigan CardioVascular Institute Selects Sage Intergy EHR to Streamline Clinical, Workflow and Reporting Efficiencies 3Health News:Michigan CardioVascular Institute Selects Sage Intergy EHR to Streamline Clinical, Workflow and Reporting Efficiencies 4Health News:Michigan CardioVascular Institute Selects Sage Intergy EHR to Streamline Clinical, Workflow and Reporting Efficiencies 5Health News:AMERIGROUP Community Care of Ohio Awarded New Health Plan Accreditation From NCQA 2Health News:Mindray Announces Preliminary 2008 Operating Results 2Health News:Mindray Announces Preliminary 2008 Operating Results 3Health News:Mindray Announces Preliminary 2008 Operating Results 4Health News:International Conference to Focus on Concerns of Young Breast Cancer Survivors 2Health News:International Conference to Focus on Concerns of Young Breast Cancer Survivors 3Health News:International Conference to Focus on Concerns of Young Breast Cancer Survivors 4Health News:FDA Clears Expanded Labeling for the Invisalign System 2
(Date:10/22/2014)... YORK , Oct. 22, 2014 Sanomedics ... August 2014 report by Global Research & Data Services, ... per year from 2014 through 2018, as demand for ... States is the world,s largest market for ... with advanced thermometers is Sanomedics International Holdings, Inc. ...
(Date:10/22/2014)... REDWOOD CITY, Calif. , Oct. 22, 2014 ... ) today announced that results from the  IAP310 ... and Pain Medicine (RAPM), a peer-reviewed journal ... placebo-controlled, Phase 3 trial evaluating the safety and ... sufentanil sublingual tablet system (SSTS), for the treatment ...
(Date:10/20/2014)... , Oct. 20, 2014  PneumRx, Inc. ( ... pulmonology, today announced completion of enrollment in their RENEW ... Clinical Study is the FDA-approved IDE pivotal trial for ... emphysema. It was anticipated that the study, ... 2013, would take until the end of 2014 to ...
Breaking Medicine Technology:Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2PneumRx Completes RENEW Pivotal Trial Enrollment 2PneumRx Completes RENEW Pivotal Trial Enrollment 3
... SuperGen Inc.,(Nasdaq: SUPG ), a pharmaceutical company ... therapies for solid tumors and,hematological malignancies, today announced ... poster presentations at the AACR Annual Meeting,which will ... An oral presentation by Dr. Steven Warner ...
... A biosimilar product for,treating the negative effects ... cells of patients is safe and exhibits an ... This is the result of a clinical phase ... Pharma GmbH and the Indian manufacturer,INTAS Biopharmaceuticals Ltd. ...
Cached Medicine Technology:SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at the AACR Annual Meeting 2SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at the AACR Annual Meeting 3Neutropenia: Biosimilar Product from India Moves One Step Closer to European Market 2Neutropenia: Biosimilar Product from India Moves One Step Closer to European Market 3
... The Sphincter of Oddi ... (PNET) works with the Polygraf™ ... and analyze pressure signals from ... The PNET software and Polygraf ...
... VoiceControl is a unique tool ... voice commands to activate shortcut ... eliminating the need to perform ... you can devote your full ...
... Analysis for POLYGRAM NET™ works with the ... analyze multichannel EGG signals. The EGG analysis ... by performing an automatic electrode impedance check ... beginning of a recording. If the electrode ...
... POLYGRAM NET™ (PNET) works with the ... analyze pressure and EMG signals from ... graphic format. The PNET software and ... or water-perfused manometry catheters as well ...
Medicine Products: