Navigation Links
Turning back the clock on aging muscles?
Date:2/20/2014

A study co-published in Nature Medicine this week by University of Toronto researcher Penney Gilbert has determined a stem cell based method for restoring strength to damaged skeletal muscles of the elderly.

Skeletal muscles are some of the most important muscles in the body, supporting functions such as sitting, standing, blinking and swallowing. In aging individuals, the function of these muscles significantly decreases.

"You lose fifteen percent of muscle mass every single year after the age of 75, a trend that is irreversible," cites Gilbert, Assistant Professor at the Institute of Biomaterials & Biomedical Engineering (IBBME) and the Donnelly Centre for Cellular & Biomolecular Research (CCBR). The study originates from Gilbert's postdoctoral research at Stanford University's Baxter Laboratory for Stem Cell Biology.

Through tracing the signaling pathways of the cells, the researchers including lead author, Professor Helen Blau, and postdoctoral researcher Ben Cosgrove determined that during aging, a subpopulation of stem cells begin to express a modification of a protein that inhibits their ability to grow and make new stem cells.

"But if we instead treated those cells outside the body with a drug that prevented that protein modification from occurring, in combination with culturing the cells on something soft that is reminiscent of soft skeletal tissue, like a hydrogel biomaterial, the combination allowed the aged cells to grow and make more copies of themselves," Gilbert describes.

The rejuvenated cell cultures were then transplanted into injured and aged tissues, with remarkable results: the transplanted cells returned strength to the damaged and aged tissues to levels matching a young, healthy state.

"We've now shown that muscle stem cells progressively lose their stem cell function during aging," Cosgrove said in a statement. "This treatment does not turn the clock back on

dysfunctional stem cells in the aged population. Rather, it stimulates stem cells from old muscle tissues that are still functional to begin dividing and self-renewing."

"An important thing to stress here is that this is not a panacea for aging in general," warns Dr. Blau. The stem cell treatment would only be used to repair localized defects in relatively small muscles found in the hip area, the throat, or the muscles in the eye.

One of the significant challenges to elderly individuals who receive hip transplants, for instance, is the challenge of repairing skeletal muscles around the hip joint injured during surgery. The study points to the potential for future post-surgery therapies that could leave elderly hip replacement patients spry in a fraction of the time.

"Even a small, localized transplantation could have a huge impact on quality of life," Blau argues, and adds, "One big advantage is that because the cells would come from the person's own muscles there would be no problem with an immune response."

"It's a really new, exciting field," says Gilbert, who argues that the muscle stem cell field, which only began to isolate muscle stem cells for study within the last five years, is especially "wide open" in Toronto where "there are really impassioned clinician researchers who are interested in restoring strength in aging and disease.


'/>"/>

Contact: Erin Vollick
comm.ibbme@utoronto.ca
416-946-8019
University of Toronto
Source:Eurekalert  

Related medicine news :

1. Turning autism upside down: When symptoms are strengths
2. Turning Stone’s Skaná Spa Honored by SpaFinder Readers as Top Casino Spa and Top Spa for Golf
3. Agein Corporation, a Leading Anti-Aging Company, Responds to Research Showing More Men Turning to Cosmetic Surgery to Increase Work Opportunities
4. TurningPoint Appraised at CMMI Level 3 for Services
5. FlipHTML5.com Now Offers A New Page Turning Maker Software
6. TurningPoint Ranks No. 1605 on the 2013 Inc. 500
7. 5000 With Three-Year Sales Growth of 247%
8. Narconon Freedom Center Celebrates Eight Years Turning Hopeless Into Dopeless
9. Scott Sheldon Introduces Point of View Series; Turning Heads and Giving You "Piece of Mind"
10. Newly Released Parenting Upward Guide: Crafted for the Adult Children of the 10,000 Baby Boomers Turning 65 Every Day
11. Could turning on a gene prevent diabetes?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Turning back the clock on aging muscles?
(Date:2/8/2016)... ... February 08, 2016 , ... Guruji Mahendra Kumar Trivedi is ... 11th, 2016 in honor of his birthday on February 10th. During this time, ... Trivedi is known by over 250,000 people from over 40 different countries as an ...
(Date:2/8/2016)... ... February 08, 2016 , ... According to research by the ... dental technicians to be certified or obtain continuing education. To increase patient awareness ... In Your Mouth?” campaign to inform dentists and patients about the possible lack ...
(Date:2/7/2016)... Birmingham, Lake Orion, Clarkston, Metamora, Michigan (PRWEB) , ... February 07, ... ... women on Friday in recognition of National Wear Red Day. National Wear Red ... heart disease and stroke in women. Heart disease and stroke cause 1 in 3 ...
(Date:2/7/2016)... ... 2016 , ... Dr. Todd Hobgood , certificated in ... surgical expertise. Technically known as deoxycholic acid or previously as ATX-101, Kybella® ... for reduction of fat below the chin (aka the “double chin”). Medication side ...
(Date:2/6/2016)... ... 2016 , ... US Sports Camps is proud to sponsor the Bay Area ... top non-profit leaders, ultimate organizations, and coaches from around the US. The theme for ... Program Director of Youth and Education, describes this year YUCC as “an important conversation ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016 ... the addition of the "Label-Free Detection ... Forecasts to 2020" report to their ... announced the addition of the "Label-Free ... Global Forecasts to 2020" report to ...
(Date:2/8/2016)... , Feb. 8, 2016  Unilife Corporation ("Unilife" or "Company") ... of injectable drug delivery systems, today announced that it will ... ended December 31, 2015 after market close on February 9, ... conference call to discuss these financial results.    ... --> About Unilife Corporation ...
(Date:2/8/2016)... 8, 2016  Sangamo BioSciences, Inc. (NASDAQ: ... announced that the U.S. Food and Drug Administration ... (IND) application for SB-318, a single treatment strategy ... Type I (MPS I). The SB-318 IND application ... a Phase 1/2 clinical study (SB-318-1502) designed to ...
Breaking Medicine Technology: