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Turning back the cellular clock
Date:6/29/2010

time that scientists have looked within a cell population to determine why some cells successfully reprogram while most fail or die along the way. The state in which cells enter the reprogramming process are thought to have an impact on the outcome.

Nature in reverse

Scientists are only beginning to understand this enigmatic process, which reverses nature by causing cells to regress back to their embryonic stage. Increased knowledge of how reprogramming cells proliferate will allow scientists to develop better real-life therapies and reduce risk to patients, says Dr. Nachman.

While embryonic stem cells culled from live embryos can be manipulated to become new "replacement" tissues such as nerve or heart cells, these reprogrammed stem cells from adults represent a safer and ethically more responsible approach, some scientists believe.

The next step for Dr. Nachman and his team is research into specific cell-type characteristics before adult cells even enter the reprogramming process. They will try to discover the molecular markers that differentiate between cells that successfully reprogram and those that do not. Several projects in their lab are now attempting to track different cell types and how they change under live imaging.


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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

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