Navigation Links
Turning back the cellular clock
Date:6/29/2010

Cell reprogramming calls The Curious Case of Benjamin Button to mind.

It's a new technology that uses molecular therapy to coax adult cells to revert to an embryonic stem cell-like state, allowing scientists to later re-differentiate these cells into specific types with the potential to treat heart attacks or diseases such as Parkinson's. But at this point in the technology's development, only one percent of cells are successfully being reprogrammed.

Now, for the first time, scientists at Tel Aviv University in collaboration with researchers at Harvard University have succeeded in tracking the progression of these cells through live imaging to learn more about how they are reprogrammed, and how the new cells evolve over time.

Dr. Iftach Nachman of TAU's Department of Biochemistry says that this represents a huge stride forward. It will not only allow researchers to develop techniques and choose the right cells for replacement therapy, increasing the efficiency of cell reprogramming, but will give invaluable insight into how these cells will eventually react in the human body. Results from the research project were recently published in the journal Nature Biotechnology.

Looking at your cell's family tree

Dr. Nachman and his fellow researchers used flourescent markers to develop their live imaging approach. During the reprogramming process, the team was able to visually track whole lineages of a cell population from their single-cell point of origin.

Cell lineage proved to be crucial for predicting how the cells would behave and whether or not they could be reprogrammed successfully, says Dr. Nachman. "By combining quantitative analysis of the data, we were able to see that these 'decisions' are made very early on. We analyzed the cells over time, and we were able to detect subtle changes that occur as early as the first or second day in a long, two-week process."

This is the first time that scientists have looked within a cell population to determine why some cells successfully reprogram while most fail or die along the way. The state in which cells enter the reprogramming process are thought to have an impact on the outcome.

Nature in reverse

Scientists are only beginning to understand this enigmatic process, which reverses nature by causing cells to regress back to their embryonic stage. Increased knowledge of how reprogramming cells proliferate will allow scientists to develop better real-life therapies and reduce risk to patients, says Dr. Nachman.

While embryonic stem cells culled from live embryos can be manipulated to become new "replacement" tissues such as nerve or heart cells, these reprogrammed stem cells from adults represent a safer and ethically more responsible approach, some scientists believe.

The next step for Dr. Nachman and his team is research into specific cell-type characteristics before adult cells even enter the reprogramming process. They will try to discover the molecular markers that differentiate between cells that successfully reprogram and those that do not. Several projects in their lab are now attempting to track different cell types and how they change under live imaging.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Related medicine news :

1. Turning metal black more than just a novelty
2. Doctors Turning to Cardiac Catheterization Too Quickly
3. New iVillage Study Reveals That Majority of Women 18-34 Go Online First With Health Questions - Before Turning to Their Doctor or Other Family Members
4. Parents of Autistic Children Turning to Alternative Treatments
5. Holistic Management and Allan Savory Win the 2010 Buckminster Fuller Award for Turning Deserts into Thriving Grasslands and Combating Climate Change.
6. Turning a painkiller into a cancer killer
7. Study Probes Causes of Anger in Returning U.S. Soldiers
8. Lack of cellular enzyme triggers switch in glucose processing
9. Key to Hepatitis C May Be Two Cellular Proteins
10. NIH/NHLBI-funded PACT Group Announces the Renewal of Production Assistance for Cellular Therapies (PACT)
11. Easy to See and Use Senior Phone Works with AT&T and T-Mobile Cellular Providers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Turning back the cellular clock
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... ... 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy ... in the United States and Canada wear eyeglasses. Once considered to be a purely ... make a fashion statement. Even celebrities use glasses as a way of creating an ...
(Date:6/26/2016)... Battle Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... abuse, joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table ... held in honor of the city’s history as home to some of the world’s ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
Breaking Medicine Technology: