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Turning back the cellular clock
Date:6/29/2010

Cell reprogramming calls The Curious Case of Benjamin Button to mind.

It's a new technology that uses molecular therapy to coax adult cells to revert to an embryonic stem cell-like state, allowing scientists to later re-differentiate these cells into specific types with the potential to treat heart attacks or diseases such as Parkinson's. But at this point in the technology's development, only one percent of cells are successfully being reprogrammed.

Now, for the first time, scientists at Tel Aviv University in collaboration with researchers at Harvard University have succeeded in tracking the progression of these cells through live imaging to learn more about how they are reprogrammed, and how the new cells evolve over time.

Dr. Iftach Nachman of TAU's Department of Biochemistry says that this represents a huge stride forward. It will not only allow researchers to develop techniques and choose the right cells for replacement therapy, increasing the efficiency of cell reprogramming, but will give invaluable insight into how these cells will eventually react in the human body. Results from the research project were recently published in the journal Nature Biotechnology.

Looking at your cell's family tree

Dr. Nachman and his fellow researchers used flourescent markers to develop their live imaging approach. During the reprogramming process, the team was able to visually track whole lineages of a cell population from their single-cell point of origin.

Cell lineage proved to be crucial for predicting how the cells would behave and whether or not they could be reprogrammed successfully, says Dr. Nachman. "By combining quantitative analysis of the data, we were able to see that these 'decisions' are made very early on. We analyzed the cells over time, and we were able to detect subtle changes that occur as early as the first or second day in a long, two-week process."

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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

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