Navigation Links
Turning back the Clock in Inherited Anemias
Date:12/4/2008

how it works.

"While it's been demonstrated that increased levels of HbF ameliorate the severity of sickle cell disease and beta-thalassemia, no direct strategies have yet been developed to increase HbF in these diseases," says Sankaran. "By reducing BCL11A expression or activity, we may be able to develop targeted therapies."

Hemoglobin is the protein in red blood cells that carries oxygen to the body's tissues. In sickle- cell disease, hemoglobin is abnormal, forming long chains that make red blood cells stiff and sickle-shaped. In thalassemia, the body's ability to produce hemoglobin is severely compromised. The hallmark of both disorders is anemia that can range from mild to life-threatening. Sickle-cell disease can cause severe pain and eventual organ damage as the abnormal, sickle-shaped cells block blood vessels, robbing tissues of their blood supply; beta-thalassemia requires frequent blood transfusions and then chelation therapy to rid the blood of excess iron that also leads to organ failure.

At birth, HbF comprises between 50 to 95 percent of a child's hemoglobin before the switch to adult hemoglobin production. The fetal form is thought to be an adaptation to the low oxygen in the fetal environment. Fetal hemoglobin has a higher affinity for oxygen, enabling it to pull oxygen more easily from the mother's circulation.

Are there potential side effects from boosting fetal hemoglobin levels? No, the researchers say. "Some people with rare genetic deletions have 100 percent fetal hemoglobin, and they're perfectly normal," says Orkin.

Orkin and Sankaran are conducting further studies to figure out how the switch from fetal to adult hemoglobin production occurs and how to target BCL11A therapeutically. "Improved understanding will permit the design of therapies for reactivation of HbF in patients with sickle-cell disease or thalassemia," says Orkin.

This study was
'/>"/>

Source: PRWeb
Copyright©2008 Vocus, Inc.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. N.J. Hospitals, Military and Veterans Affairs Join Broad Effort to Improve Returning Vets Healthcare
2. Turning Clocks Back Increases Risk of Drowsy Driving
3. With the Economy of the United States at a Turning Point, Health Care Could Be Our Next Serious Crisis ...
4. Science Fiction Has Become Reality with Remarkable Anti-Aging Treatment Breakthrough - Turning Back the Biological Clock in Aging
5. Drinking Problems Greater Among Returning Combat Veterans
6. Turning Life Insurance to Cash
7. Karen Haney Joins The Turning Point Group as Partner and Vice President of Client Services - Healthcare
8. Growing Public Health Crisis of Domestic Violence and Suicides by Returning Veterans
9. RAI CEO: Returning Value in a Challenging Time
10. Courage Center Offers Credentialed Educational Forum on Issues of Returning Injured Employees to Work
11. Chehalis Tribes Announce Benefit to Help Returning Combat Veterans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Turning back the Clock in Inherited Anemias
(Date:9/3/2015)... ... ... Mum n Me is pleased to announce the launch of its ... maximum protection from sun exposure, wind, bugs, and germs. The Mum n Me Baby ... keeping the cover securely in place. The new car seat cover is made with ...
(Date:9/3/2015)... ... September 03, 2015 , ... At Renew Man™, we have seen an increasing ... care model, where the primary care physician dictates and the patient obeys. Instead, our ... about their health issues and empowered to choose their own treatment options. , Recognizing ...
(Date:9/3/2015)... Kingston, NY (PRWEB) , ... September 03, 2015 , ... ... on iTunes, April Hannah & Michael Habernig from Path 11 Productions have had great ... This new age podcast has featured Hay House authors, Teal Swan who is the ...
(Date:9/3/2015)... ... September 03, 2015 , ... Doctor Kayode Sotonwa ... health professionals out there. His perspective on internal medicine keeps patients happy and healthy, ... healthy is important regardless of the season, but even more so in the fall, ...
(Date:9/2/2015)... ... September 03, 2015 , ... The Aspen Clinic (TAC), ... retreats geared towards kick-starting and inspiring wellness in the Roaring Fork Valley and beyond. ... developing a whole mind-body approach to fitness - we are much more than a ...
Breaking Medicine News(10 mins):Health News:Mum n Me Announces New Baby Car Seat Cover 2Health News:Men Dissatisfied with the Primary Care Physician’s Approach to Andropause Are Turning to Renew Man™ 2Health News:Men Dissatisfied with the Primary Care Physician’s Approach to Andropause Are Turning to Renew Man™ 3Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 3Health News:Doctor Kayode Sotonwa Highlights Expert Tips for Staying in Shape This Fall 2Health News:TAC Introduces New Retreats for Fall Fitness 2
... An international team of cancer specialists and imaging ... response to treatment//. The guidelines will provide clinicians ... clinical trials of lymphoma treatments and should facilitate ... guidelines developed by the International Harmonization Project (IHP) ...
... born to mothers who smoked during pregnancy may find ... study//. ,A recent animal research suggests that ... find it difficult to quit smoking. Duke University Medical ... to nicotine is known to alter areas of the ...
... insurance to around 1.2 million families below the poverty ... ,"We are aware of the health challenges and ... decided to provide health insurance to BPL families, and ... project this year," Kumaraswamy said in Ingalagi village in ...
... suffering from asthma compared to other methods of ... of different medicines. ,Although several ... clinical trials directly comparing them have not been ... ,For the first time, researchers in the Childhood ...
... Some obese have not looked up from their plate full of ... for the free obesity surgery.// ,Earlier, the government ... medical condition could get the obesity surgery done, free of cost. ... avail the free surgery offered by the government. ,People ...
... stress and depression,// may be associated with higher ... in turn are related to an increased risk for ... 22 issue of Archives of Internal Medicine, one of ... studies have linked psychosocial characteristics with cardiovascular disease and ...
Cached Medicine News:Health News:New Guidelines For Assessing Lymphoma Treatment 2Health News:New Guidelines For Assessing Lymphoma Treatment 3Health News:Quitting Not Easy for Smokers Born to Smoking Women 2Health News:Karnataka's Free Health Insurance to the Poor 2Health News:Psychosocial Factors Associated With Higher Levels of Inflammatory Markers 2
(Date:9/2/2015)... Pa. , Sept. 2, 2015 ... increases, diversifies revenue base with highly profitable specialty ... , Near-term growth potential with 11 product ... include Paragraph IV certifications  , Provides medium ... candidates in development, including eight controlled substances ...
(Date:9/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/275q7t/inhaled_drug ) has announced ... UK - November 19-20, 2015)" conference to their ... cover industry case studies, regulatory updates, latest therapies and ... Steven Nichols , OINP Specialist Consultant and ... Companies participating include: - Aptar Pharma ...
(Date:9/2/2015)... 2, 2015  Seeger Weiss LLP is reporting that ... commence October 13, 2015. Since the ... approval program, Zimmer NexGen knee implant surpassed FDA investigation ... companies provide evidence that the product is substantially similar ... gain permissions. In 2001, Zimmer began ...
Breaking Medicine Technology:Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 2Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 3Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 4Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 5Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 6Seeger Weiss LLP Reports That Zimmer NexGen Knee MDL Bellwether Trial Date Set For October 13, 2015 2
... With the increase in Endoscopic cases it is ... Monitor with the Surgical Light. This combination ... without having to adopt an uncomfortable pose. ... including the NUVO Monitoring System. As such ...
... This configuration offers all the performance of a ... perfectly for use in Outpatient Settings, Minor Procedure ... Mounting two single lights either side of the ... in a General OR when combining Flat Screen ...
A Western Blot Immunassay for the detection of antibodies to primarily anti-myelin associated glycoproteins (anti-MAG) and other glycolipid autoantibodies in human serum....
Triturus® is an open and completely automated ELISA immunoassay analyzer which can perform a variety of different tests on a series of samples and process several batches simultaneously....
Medicine Products: