Navigation Links
Turning back the Clock in Inherited Anemias
Date:12/4/2008

how it works.

"While it's been demonstrated that increased levels of HbF ameliorate the severity of sickle cell disease and beta-thalassemia, no direct strategies have yet been developed to increase HbF in these diseases," says Sankaran. "By reducing BCL11A expression or activity, we may be able to develop targeted therapies."

Hemoglobin is the protein in red blood cells that carries oxygen to the body's tissues. In sickle- cell disease, hemoglobin is abnormal, forming long chains that make red blood cells stiff and sickle-shaped. In thalassemia, the body's ability to produce hemoglobin is severely compromised. The hallmark of both disorders is anemia that can range from mild to life-threatening. Sickle-cell disease can cause severe pain and eventual organ damage as the abnormal, sickle-shaped cells block blood vessels, robbing tissues of their blood supply; beta-thalassemia requires frequent blood transfusions and then chelation therapy to rid the blood of excess iron that also leads to organ failure.

At birth, HbF comprises between 50 to 95 percent of a child's hemoglobin before the switch to adult hemoglobin production. The fetal form is thought to be an adaptation to the low oxygen in the fetal environment. Fetal hemoglobin has a higher affinity for oxygen, enabling it to pull oxygen more easily from the mother's circulation.

Are there potential side effects from boosting fetal hemoglobin levels? No, the researchers say. "Some people with rare genetic deletions have 100 percent fetal hemoglobin, and they're perfectly normal," says Orkin.

Orkin and Sankaran are conducting further studies to figure out how the switch from fetal to adult hemoglobin production occurs and how to target BCL11A therapeutically. "Improved understanding will permit the design of therapies for reactivation of HbF in patients with sickle-cell disease or thalassemia," says Orkin.

This study was
'/>"/>

Source: PRWeb
Copyright©2008 Vocus, Inc.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. N.J. Hospitals, Military and Veterans Affairs Join Broad Effort to Improve Returning Vets Healthcare
2. Turning Clocks Back Increases Risk of Drowsy Driving
3. With the Economy of the United States at a Turning Point, Health Care Could Be Our Next Serious Crisis ...
4. Science Fiction Has Become Reality with Remarkable Anti-Aging Treatment Breakthrough - Turning Back the Biological Clock in Aging
5. Drinking Problems Greater Among Returning Combat Veterans
6. Turning Life Insurance to Cash
7. Karen Haney Joins The Turning Point Group as Partner and Vice President of Client Services - Healthcare
8. Growing Public Health Crisis of Domestic Violence and Suicides by Returning Veterans
9. RAI CEO: Returning Value in a Challenging Time
10. Courage Center Offers Credentialed Educational Forum on Issues of Returning Injured Employees to Work
11. Chehalis Tribes Announce Benefit to Help Returning Combat Veterans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Turning back the Clock in Inherited Anemias
(Date:7/30/2014)... HealthDay Reporter WEDNESDAY, July 30, 2014 ... least 2,000 Americans die from extreme heat or cold, floods ... stroke or sun stroke caused nearly one-third of more than ... the U.S. Centers for Disease Control and Prevention. Cold ... -- accounted for 63 percent of those weather-related deaths. The ...
(Date:7/30/2014)... CA (PRWEB) July 30, 2014 SF ... accessories at the lowest prices on the internet with ... Cables in two lengths and two colors. These lightning ... standards. , The high quality SF Cable ... connector with digital signal delivering faster charging and syncing. ...
(Date:7/30/2014)... Visitors to our region recognize how special it ... protection. Bob Kiesendahl, one of the owners of Woodloch ... Conservancy for donations collected through participation in the Green ... fast, as visitors welcome the opportunity to invest in ... The Kiesendahl family has owned Woodloch Resort for multiple ...
(Date:7/30/2014)... DRE Medical — a leading medical equipment company ... Medical Trade Shows & Conventions Calendar Schedule , ... vendors. , The calendar is a continually-updating guide to ... and around the world. Hundreds of entries are currently ... growing. , Information listed on each trade show entry ...
(Date:7/30/2014)... The Ehlers-Danlos National Foundation (EDNF) is ... Aiken Chack will serve as chair. The board was ... Annual Learning Conference in Houston, Texas July 10-12. ... ahead of us. From the rollout of the first ... Greater Baltimore Medical Center to our September physicians conference ...
Breaking Medicine News(10 mins):Health News: Extreme Weather Kills 2,000 in U.S. Each Year: CDC 2Health News: Extreme Weather Kills 2,000 in U.S. Each Year: CDC 3Health News:SF Cable Delivers Certified Lightning Cable in Multiple Sizes and Colors 2Health News:Pocono Mountain Resort Guests Contribute Over $8500 to Protect Land in 6 Short Months 2Health News:DRE Launches Online Interactive Medical Trade Show Calendar 2Health News:Ehlers-Danlos National Foundation Announces New Leadership 2
... a study published in the recent issue of Annals ... exercise //as preconditions to prevent and control diabetes type ... cost effective to control diabetes through rigorous exercise and ... diabetes reduces the body’s ability to store calories, resulting ...
... at the annual meeting of the American Academy of Orthopedic ... back pain may be the result of several problems other ... restrict the effect of a surgery. The study that had ... National Spine Network, US, said that patients who had other ...
... 100 patients at an ear , nose and throat clinic ... snoring // shouldn't expect to receive a diagnosis of obstructive ... examination alone instead an overnight sleep testing needs to be ... ,For the study, physicians evaluated the patients with a ...
... now that after delivery depressions, that had plagued new mothers all ... the delivery. As a result of this belief, many pregnant women ... new study that comes in the recent issue of British Medical ... to Deirdre Murphy of Dundee University, who had led the team ...
... twins and their mothers to see if there was a ... // of life and children's antisocial behavior by age 7 ... have increased problems with conduct and more antisocial behavior . ... the twins' birth and the likeliness of antisocial behavior in ...
... to treat agitation in patients with Alzheimer's or dementia, ... findings of a recent study .// ,For ... Twenty-six of the patients received quetiapine (an antipsychotic also ... also known as Exelon), and 29 received a placebo. ...
Cached Medicine News:
(Date:7/30/2014)... -- Cynosure, Inc. (NASDAQ: CYNO ), ... and minimally invasive applications, today announced that the Board of ... Chief Financial Officer Timothy W. Baker to President ... continue to serve as CFO and will take the title ... and Chief Executive Officer. "Tim has been ...
(Date:7/30/2014)... PHILADELPHIA , July 30, 2014  Packaging Coordinators, ... a definitive agreement to acquire Penn Pharmaceutical Services Limited ... Wales in the United Kingdom ... New Hope, Pennsylvania and Tokyo ... manufacturing services, including Clinical and Commercial dosage form manufacturing, ...
(Date:7/30/2014)... --  Medical Equipment Solutions, Corp. are pleased to ... Defense (US Army) contract valued at over $2 million ... machine and technical support staffing. As an 8-A Certified ... Administration (SBA), Medical Equipment is proud to support American ... diagnostic equipment. The SBA 8-A certification is a favored ...
Breaking Medicine Technology:Cynosure Appoints Chief Operating Officer and Chief Financial Officer Timothy W. Baker as President 2PCI Announces Definitive Agreement to Acquire Penn Pharma 2PCI Announces Definitive Agreement to Acquire Penn Pharma 3PCI Announces Definitive Agreement to Acquire Penn Pharma 4PCI Announces Definitive Agreement to Acquire Penn Pharma 5Medical Equipment Solutions Corp. Awarded $2 Million contract To Service DoD 2
... , MINNEAPOLIS, Oct. 29 Nonin Medical, Inc., ... awarded the Medical Technology Award and its owner and ... Year by the Minnesota High Tech Association (MHTA), in ... Playing a significant role in bringing new technology to ...
... Oct. 29 PRO-DEX, INC. (Nasdaq: PDEX ) today ... September 30, 2009. In addition, Pro-Dex announced that its ... new marketing director has been hired, a product development agreement ... been made of a newly developed product. , Sales for ...
Cached Medicine Technology:Nonin Medical Recognized for Influential Contributions in Medical Technology 2PRO-DEX, INC. Announces Fiscal First Quarter 2010 Profit, Update on Business Development Activities, and Renewal of Banking Agreement 2PRO-DEX, INC. Announces Fiscal First Quarter 2010 Profit, Update on Business Development Activities, and Renewal of Banking Agreement 3PRO-DEX, INC. Announces Fiscal First Quarter 2010 Profit, Update on Business Development Activities, and Renewal of Banking Agreement 4PRO-DEX, INC. Announces Fiscal First Quarter 2010 Profit, Update on Business Development Activities, and Renewal of Banking Agreement 5PRO-DEX, INC. Announces Fiscal First Quarter 2010 Profit, Update on Business Development Activities, and Renewal of Banking Agreement 6PRO-DEX, INC. Announces Fiscal First Quarter 2010 Profit, Update on Business Development Activities, and Renewal of Banking Agreement 7PRO-DEX, INC. Announces Fiscal First Quarter 2010 Profit, Update on Business Development Activities, and Renewal of Banking Agreement 8PRO-DEX, INC. Announces Fiscal First Quarter 2010 Profit, Update on Business Development Activities, and Renewal of Banking Agreement 9PRO-DEX, INC. Announces Fiscal First Quarter 2010 Profit, Update on Business Development Activities, and Renewal of Banking Agreement 10
... light weight and strong, the ThumSaver CMC Short ... at the CMC and/or MP joints of the ... motion and full IP joint motion for function. ... or Skiers thumb, and for rest due to ...
... This is an excellent choice to treat ... MCP joint, basal joint arthritis, advanced carpal ... the thumb and wrist. Distal palmar ... flexion and full finger dexterity. Constructed ...
... custom wrist orthotic designed to limit the extension and ... range-of-motion. , ,Indications: , Wrist reconstruction ... , Coles fracture - distal radius ... rupture , ORIF - Open reduction and ...
The Contoured Wrist/Forearm Support provides comfort for post-surgical immobilization, post-fracture casting, and wrist sprains and strains....
Medicine Products: