Navigation Links
Turning agents of disease into tools for health and better living
Date:6/30/2011

Viruses that attack plants, insects, mammals and bacteria are proving effective platforms for delivering medicines and imaging chemicals to specific cells in the body, as building blocks for tiny battery electrodes and computer data storage devices, and other nanotechnologies.

The burst of research over the last two decades, with explanations aimed at undergraduate and graduate college students and scientists within and outside the field, is described in a new book written by Nicole Steinmetz, an assistant professor of biomedical engineering at Case Western Reserve University, and Marianne Manchester, a professor of pharmacy and pharmaceutical sciences at the University of California at San Diego.

The textbook, Viral Nanoparticles: Tools for Materials Science and Biomedicine, summarizes the work done by engineers, chemists, physicists, materials scientists, medical researchers and others; the viruses used and the applications. The book is available now.

"The field is rapidly expanding, with people from more and more backgrounds coming into it," said Steinmetz, who has been manipulating viruses since she was an undergraduate researcher. Earlier in her career she created multilayered thin film arrays made of multiple 3-dimensional viral nanoparticles for use in sensors or nanoelectronics, but is now focusing on the application of plant viruses for medical use, such as cancer detection and imaging and targeted drug delivery.

Manchester has long specialized in the interface between viral nanoparticles and physiologic systems, defining the ways that viruses interact with cell surfaces and organs within the body. "The field is now poised to move forward toward commercial and clinical applications," she said. "The book provides an overview of these challenges and opportunities".

Viruses are finding a wide range of uses in nanoscience and nanotechnology, because of a host of practical traits, she explains. Viruses are already nano-sized 100,000s of times smaller than the width of a human hair. Their structures have been optimized by nature, physically and chemically each unit of the same strain of virus is identical, they're cheap and easy to produce and they easily self-assemble into two-and three-dimensional structures.

The infectious agents are also stable, hardy and biocompatible.

The book details how researchers have mineralized viruses to produce nanowires used in nanoelectronics, and build thin-film micro-arrays. The authors explain how scientists have rendered the infectious agents benign, as well as genetically or chemically altered versions for specific uses.

They tell how they and others have modified the surfaces of viral nanoparticles to link up with targets, such as tumor cells, and modified their interiors to carry medicines, fluorescent chemicals used in imaging applications, or other cargo.


'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Sniffing out lymphoma by turning dogs into humans
2. Some women worry too much about breast cancer returning, U-M study finds
3. Innovative virtual reality exposure therapy shows promise for returning troops
4. Turning off stress
5. Gene identified that prevents stem cells from turning cancerous
6. Microbicide trial results a turning point for HIV prevention, says team testing same gel
7. Turning back the cellular clock
8. Study Probes Causes of Anger in Returning U.S. Soldiers
9. Turning a painkiller into a cancer killer
10. Holistic Management and Allan Savory Win the 2010 Buckminster Fuller Award for Turning Deserts into Thriving Grasslands and Combating Climate Change.
11. Parents of Autistic Children Turning to Alternative Treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... January 19, 2017 , ... In 2009, Carol Bryan endured ... in severe facial disfiguration. After four frightening years of isolation and emotional and ... Center, who removed the substances in a partial facial transplant through eight surgeries. ...
(Date:1/19/2017)... , ... January 19, 2017 , ... ... and staff members in 2017 who are passionate about making a difference in ... 1994 and headquartered in Tampa, UMA, a nonprofit healthcare educational institution, has more ...
(Date:1/19/2017)... ... January 19, 2017 , ... Tribble Insurance Agency, a family ... Virginia region, is inaugurating a charity event to honor Chad Phillip Dermyer, a local ... last year, Chad Phillip Dermyer and his fellow officers were conducting routine stops of ...
(Date:1/19/2017)... ... 19, 2017 , ... Creative messages to prevent distracted driving ... Impact Teen Drivers and California Casualty. Entries from students aged 14-22 can be ... $15,000 will be awarded for the best peer-to-peer messages sharing solutions to reckless ...
(Date:1/19/2017)... ... , ... Connecticut Dermatology Group (CDG) is proud and excited to welcome back ... Dr. Kim brings an extensive background in cutting-edge dermatology care and research to Connecticut’s ... back Dr. Kim to the CDG team” said President and Managing Partner Dr. Steven ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 18, 2017   Synthetic Biologics, ... company developing therapeutics designed to preserve the microbiome ... today confirmed plans to initiate a Phase 2b/3 ... reformulation of lovastatin lactone designed to reduce methane ... in the gut to treat the underlying cause ...
(Date:1/18/2017)... 18, 2017  Aprima Medical Software, a leading ... management (PM) and revenue cycle management (RCM) solutions ... a former reseller Healthcare Data Solutions (HDS) of ... Aprima will assume full support for HDS,s customers, ... practices across 15 states. Financial terms were not ...
(Date:1/18/2017)... 18, 2017   Spotlight Innovation Inc. ... plans, in the second quarter of 2017, to ... intended to provide relief from chronic pain, is ... It was developed under a licensing agreement with ... derived from snake venom. Additionally, Caretta Therapeutics has ...
Breaking Medicine Technology: