Navigation Links
Turning a painkiller into a cancer killer
Date:6/14/2010

LA JOLLA, Calif., June 15, 2010 Without knowing exactly why, scientists have long observed that people who regularly take non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin have lower incidences of certain types of cancer. Now, in a study appearing in Cancer Cell on June 15, investigators at Sanford-Burnham Medical Research Institute (Sanford-Burnham) and their colleagues have figured out how one NSAID, called Sulindac, inhibits tumor growth. The study reveals that Sulindac shuts down cancer cell growth and initiates cell death by binding to nuclear receptor RXRα, a protein that receives a signal and carries it into the nucleus to turn genes on or off.

"Nuclear receptors are excellent targets for drug development," explained Xiao-kun Zhang, Ph.D., professor at Sanford-Burnham and senior author of the study. "Thirteen percent of existing drugs target nuclear receptors, even though the mechanism of action is not always clear."

RXRα normally suppresses tumors, but many types of cancer cells produce a truncated form of this nuclear receptor that does just the opposite. This study showed that shortened RXRα enhances tumor growth by stimulating other proteins that help cancer cells survive. Luckily, the researchers also found that Sulindac can be used to combat this deviant RXRα by switching off its pro-survival function and turning on apoptosis, a process that tells cells to self-destruct.

Sulindac is currently prescribed for the treatment of pain and fever, and to help relieve symptoms of arthritis. The current study demonstrates a new application for Sulindac as a potential anti-cancer treatment that targets truncated RXRα protein in tumors. However, some NSAIDs have gotten a lot of bad press for their potentially dangerous cardiovascular side effects. To overcome this limitation, the researchers tweaked Sulindac, creating a new version of the drug now called K-80003 that both decreases negativ
'/>"/>

Contact: Josh Baxt
jbaxt@sanfordburnham.org
858-795-5236
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Holistic Management and Allan Savory Win the 2010 Buckminster Fuller Award for Turning Deserts into Thriving Grasslands and Combating Climate Change.
2. Parents of Autistic Children Turning to Alternative Treatments
3. New iVillage Study Reveals That Majority of Women 18-34 Go Online First With Health Questions - Before Turning to Their Doctor or Other Family Members
4. Doctors Turning to Cardiac Catheterization Too Quickly
5. Turning metal black more than just a novelty
6. Acupuncture May Trigger Natural Painkiller
7. New Form of Painkiller May Fight Colon Cancer
8. Another perk of painkillers? Decreased hormone levels may reduce cancer risk
9. Painkillers Lower Estrogen Levels, May Explain Cancer Reduction Risk
10. Overdoses From Prescription Painkillers on the Rise
11. Makers of Powerful Painkillers Present Safety Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... N-Zyme Scientifics LLC achieved a major ... product a mere 8 months after company startup. Its ... glycan release enzyme used in the “Biologics” industry for ... for tissue pathology on Mass Spec devices. PRIME™ is ... North American market (PNGase F PRIMETM). N-Zyme is ...
(Date:9/17/2014)... Recently, BambooIndustry.com, an outstanding company in the ... floorings . There are more than 1000 items in this ... big promotion for these useful items. Each of them is ... , “We are very proud to unveil the new ... these items are made with natural materials by experienced workers. ...
(Date:9/17/2014)... 18, 2014 Recently, UWDress.com, an innovative ... women’s special occasion outfits, has released its 2014 ... the firm has launched a big sale for these ... available at deeply discounted rates, from 15 to 65 ... company insists on using comfortable to wear materials. Its ...
(Date:9/17/2014)... September 18, 2014 Dr. Shalev is a ... to Houston to study at the University of Texas, and ... studying she realized her real passion lay in dentistry, and ... from the University of Texas Health Science Center at Houston ... and is a member of The Greater Houston Dental Society, ...
(Date:9/17/2014)... 18, 2014 The National Resident Matching ... , a comprehensive analysis of the relationship between unique ... specialty. The new edition is based on the ... for U.S. allopathic medical school senior students and all ... able to provide this new edition of Charting Outcomes ...
Breaking Medicine News(10 mins):Health News:N-Zyme Scientifics Announces Successful Product Launch 2Health News:More Than 1000 Items Added To BambooIndustry.com’s Bamboo Flooring Collection 2Health News:2014 Empire Waist Evening Dress Collection Now Unveiled At UWDress.com 2Health News:Just Released: Charting Outcomes in the Match for the 2014 Main Residency Match® 2Health News:Just Released: Charting Outcomes in the Match for the 2014 Main Residency Match® 3
... 5 (HealthDay News) -- Giving antibiotics to pregnant women at ... newborns, according to a new study. Use of antibiotics ... and should also be used in developing countries, at least ... Edmond, of the London School of Hygiene and Tropical Medicine ...
... WASHINGTONThe rezoning around a planned light rail line in the ... the health of the people in the communities it would ... today by PolicyLink, TakeAction Minnesota, and ISAIAH, a nonprofit coalition ... Paul and St. Cloud region. The HIA was made possible ...
... Reporter , WEDNESDAY, Jan. 4 (HealthDay News) -- A vaccine ... severe liver damage and even liver cancer, might be possible ... , There is currently no vaccine for hepatitis C, which ... HIV, the hepatitis C virus mutates easily and has always ...
... HealthDay Reporter , WEDNESDAY, Jan. 4 (HealthDay News) -- ... United States in recent years are charted in a new report. ... by 1.8 percent a year in men and 1.6 percent a ... And from 1990 through 2008, death rates plunged almost 23 percent ...
... quality of life higher in cancer survivors who exercise, ... though most doctors recommend exercise, many patients fail ... University of Colorado Cancer Center, recently published in the ... by the American College of Sports Medicine, makes planning ...
... The rotovirus vaccine was pulled from the marketplace in ... the updated rotavirus vaccines do not appear to increase ... to a new study by child health experts at ... of the vaccine,re-introduced in 2006 and 2008, prevent infection ...
Cached Medicine News:Health News:Antibiotics in Pregnancy May Shield Newborns From Strep B 2Health News:Twin Cities light rail project presents both opportunities and risks for health, according to report 2Health News:Twin Cities light rail project presents both opportunities and risks for health, according to report 3Health News:Novel Hepatitis C Vaccine Shows Some Early Promise 2Health News:Novel Hepatitis C Vaccine Shows Some Early Promise 3Health News:Cancer Incidence, Death Rates Continue to Drop: Report 2Health News:Cancer Incidence, Death Rates Continue to Drop: Report 3Health News:Downloadable tool helps cancer survivors plan and monitor exercise 2Health News:U-M study shows updated rotavirus vaccine not linked to increase in bowel obstruction 2
(Date:9/17/2014)... , Sept. 17, 2014 Cardiac Dimensions ... data from the TITAN II clinical trial of ... and sustained improvements in mitral regurgitation, functional improvement, ... long-term safety and efficacy data, which was consistent ... Sept. 13 at the 26 th annual ...
(Date:9/17/2014)... 17, 2014  Neuraltus Pharmaceuticals, Inc. announced today that ... program of NP001 for the treatment of amyotrophic lateral ... being highlighted today in an oral presentation at the ... being held in Bloomington, Minnesota , ... administration of a high dose of NP001 (2mg/kg) was ...
(Date:9/17/2014)... and MILL VALLEY, Calif. ... Sarcoma Alliance today announced a partnership in the ... will sponsor the Sarcoma Alliance Suzanne Renee Leider ... program offers financial assistance to reimburse sarcoma patients ... opinion from a sarcoma specialist. Scientific literature reinforces ...
Breaking Medicine Technology:Cardiac Dimensions Announces New Long-Term Outcomes Data From TITAN II Clinical Trial Demonstrates Safety, Efficacy Of Enhanced CARILLON Mitral Contour System 2Cardiac Dimensions Announces New Long-Term Outcomes Data From TITAN II Clinical Trial Demonstrates Safety, Efficacy Of Enhanced CARILLON Mitral Contour System 3Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 2Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 3Champions Oncology Partners with Sarcoma Alliance to Bring Personalized Treatment Options to Sarcoma Patients 2Champions Oncology Partners with Sarcoma Alliance to Bring Personalized Treatment Options to Sarcoma Patients 3
... 31, 2011 Luminex Corporation (Nasdaq: LMNX ... Jefferies 2011 Global Healthcare Conference to be held June ... ) The investor presentation by Patrick ... at 9:00 a.m. Eastern time on Tuesday, June 7, 2011. ...
... 2011 The Procter & Gamble Company (NYSE: ... its U.S. Sustainability Expert Advisory Panel (SEAP). The new members ... Manager, Clinton Global Initiative Dr. Howard Frumkin – Dean, ... Terry Tamminen – Former Secretary, California Environmental Protection Agency ...
Cached Medicine Technology:Luminex Corporation to Present at Jefferies 2011 Global Healthcare Conference 2P&G Welcomes New Members to U.S. Sustainability Expert Advisory Panel 2P&G Welcomes New Members to U.S. Sustainability Expert Advisory Panel 3