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Turning Back the Clock: Fasting Prolongs Reproductive Life Span
Date:9/4/2009

esized that this protein may interface with calorie restriction to extend life span, until now its role in protecting and extending reproductive longevity in the face of starvation had not been known. "In worms that contained an inactive NHR-49 gene, reproductive recovery and fertility after starvation were severely impaired," he said. "We found that reproductive arrest and recovery are highly dependent on a functioning NHR-49 gene."

NHR-49 in worms is analogous to various proteins in humans, all of which belong to a family of proteins called nuclear receptors. Nuclear receptors, such as estrogen receptors and androgen receptors, are particularly good targets for pharmaceutical intervention. "The identification of a nuclear receptor that turns on and off the beneficial response to nutrient deprivation would be of great interest because it would be a candidate for drugs aimed at tricking the body, or specifically the reproductive system, into thinking they are calorically restricted or starved, even when food intake is normal," Van Gilst said.

The biomedical implications of model organisms such as flies and worms cannot be overlooked, he said. "Many paradigm-shifting discoveries in C. elegans have since been replicated in humans. Therefore, the idea that our findings will be relevant to human reproduction is a possibility that certainly needs exploration," he said.

However, Van Gilst is quick to point out that even if this mechanism is conserved in humans, it is still unknown what degree of caloric restriction would be required to impact egg production in humans. "If such a process exists in humans, it likely evolved to help our ancestors preserve fertility during periods of famine or food shortage. We certainly don't have a prescription for famine. Consequently, our study should not be used to promote potentially dangerous interventions such as severe caloric restriction and starvation as a means to restore a
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SOURCE Fred Hutchinson Cancer Research Center
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