Navigation Links
Turning Back the Clock: Fasting Prolongs Reproductive Life Span
Date:9/4/2009

esized that this protein may interface with calorie restriction to extend life span, until now its role in protecting and extending reproductive longevity in the face of starvation had not been known. "In worms that contained an inactive NHR-49 gene, reproductive recovery and fertility after starvation were severely impaired," he said. "We found that reproductive arrest and recovery are highly dependent on a functioning NHR-49 gene."

NHR-49 in worms is analogous to various proteins in humans, all of which belong to a family of proteins called nuclear receptors. Nuclear receptors, such as estrogen receptors and androgen receptors, are particularly good targets for pharmaceutical intervention. "The identification of a nuclear receptor that turns on and off the beneficial response to nutrient deprivation would be of great interest because it would be a candidate for drugs aimed at tricking the body, or specifically the reproductive system, into thinking they are calorically restricted or starved, even when food intake is normal," Van Gilst said.

The biomedical implications of model organisms such as flies and worms cannot be overlooked, he said. "Many paradigm-shifting discoveries in C. elegans have since been replicated in humans. Therefore, the idea that our findings will be relevant to human reproduction is a possibility that certainly needs exploration," he said.

However, Van Gilst is quick to point out that even if this mechanism is conserved in humans, it is still unknown what degree of caloric restriction would be required to impact egg production in humans. "If such a process exists in humans, it likely evolved to help our ancestors preserve fertility during periods of famine or food shortage. We certainly don't have a prescription for famine. Consequently, our study should not be used to promote potentially dangerous interventions such as severe caloric restriction and starvation as a means to restore a
'/>"/>

SOURCE Fred Hutchinson Cancer Research Center
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Depression Taking Toll on Returning U.S. Vets
2. Returning Troops Get Help for PTSD
3. Easter Seals Launches Program for Veterans Returning from Iraq and Afghanistan with Traumatic Brain Injuries
4. Lilly Grant to VA Will Enhance Services for Returning Combat Veterans
5. Capsule endoscopy turning up undiagnosed cases of Crohns disease
6. Remarks by President Bush, Senator Bob Dole and Secretary Donna Shalala on Commission on Care for Americas Returning Wounded Warriors Report Implementation
7. Turning Pointe Therapeutic Riding Recognized for Excellence in Providing Equine-Assisted Therapies to People with Disabilities
8. Non-Profit Calls on Mental Health Professionals to Honor Veterans Day by Giving an Hour of Free Counseling to Returning Veterans
9. VH1 Set to Continue Its Record-Breaking Pace Into 2008 with Brand New Premieres and Returning Series
10. USA TODAY to Report Special Series "Turning 62: The Retirement Boom Begins"
11. Turning on adult stem cells may help repair bone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 30, 2014) The phrase "we caught it early" is ... the midst of a cancer diagnosis. Combating cancer in ... a certain part of the body, gives patients the ... skin, colon, prostate and other forms of cancer are ... care providers recommend cancer screenings as a precautionary measure, ...
(Date:7/30/2014)... ... ... ... , UCLA researchers interviewed people with diverticulitis and confirmed ... the peer-reviewed journal Quality of Life Research , a UCLA team led by Dr. Brennan Spiegel interviewed patients in great detail ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Over 630 ... Pinhole Surgical Technique®, the revolutionary minimally invasive treatment for ... considered by many of his peers to be the ... speaker at a recent Chao Pinhole Surgical Technique® training ... Dr. Shanelec is the recipient of the American Academy ...
(Date:7/30/2014)... 30, 2014 The American Telemedicine ... Sens. Thad Cochran (R-MS) and Roger Wicker (R-MS) ... telemedicine coverage under Medicare, Medicaid and Federal Communications ... Mississippi Republicans, introduced the Telehealth Enhancement Act as ... version, H.R. 3306, introduced by Rep. Gregg Harper ...
(Date:7/30/2014)... NY (PRWEB) July 30, 2014 The ... school, is pleased to announce that Arianna Huffington has joined ... curriculum of the Health Coach Training Program . , ... Huffington Post, a world-renowned news and blogging site that won ... the author of fourteen books and was included on the ...
Breaking Medicine News(10 mins):Health News:UK psychologist creates patient tool to assist with lung cancer screening decision 2Health News:UK psychologist creates patient tool to assist with lung cancer screening decision 3Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 2Health News:Diverticulitis patients reveal psychological, physical symptoms long after acute attacks 3Health News:Periodontist Dr. Dennis Shanelec Comments On The Chao Pinhole Surgical Technique® Training Course 2Health News:ATA Applauds Senators’ Push for Federal Telemedicine Improvements 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 3
... Care,Compliance Association (HCCA) will host a two-part audio/web ... for physicians,outlined in the U.S. Department of Health ... Work Plan. It is an essential resource for ... conference will provide an in-depth,review of issues and ...
... Family Walk on November 17th to Raise Awareness and,Funds to Fight Homelessness in ... ... America, LOS ANGELES, Oct. 15 United Way of Greater Los Angeles,today ... on November 17, 2007 called HomeWalk, part of its A Pathway Home,initiative to ...
... increased range of motion, study found , MONDAY, ... given before and after surgery, helped reduce pain and ... That study finding was presented Sunday at the annual ... Francisco. , The study, funded by drug maker Pfizer ...
... could lead to new drugs, researchers add , , MONDAY, ... scan not only appears capable of spotting multiple sclerosis earlier ... a way to track progression of the illness, as well ... , "We,re in the process of validating this [eye exam] ...
... awarded members,of state and municipal governments its 2007 ... being held in Washington,D.C. Easter Seals created its ... and appointed -- for their work to improve ... for all. "These public officials are leaders ...
... World Renowned Atlanta Surgeons Join Forces to Create a Totally Unique ... ... Medical Spa is the newest project,from Atlanta based team, Dr. Randy Rudderman ... invasive medical procedures,the plastic and thoracic surgeons are taking on varicose vein ...
Cached Medicine News:Health News:Critical HCCA Web/Audio Conference Will Review Office of Inspector General Compliance Concerns Outlined in FY 2008 Work Plan 2Health News:United Way of Greater Los Angeles Kicks Off Initiative to Prevent and End Homelessness With HomeWalk 2007 2Health News:United Way of Greater Los Angeles Kicks Off Initiative to Prevent and End Homelessness With HomeWalk 2007 3Health News:United Way of Greater Los Angeles Kicks Off Initiative to Prevent and End Homelessness With HomeWalk 2007 4Health News:Anti-Convulsant Aids Knee-Replacement Patients 2Health News:Eye Scan May Help Diagnose, Treat MS 2Health News:Eye Scan May Help Diagnose, Treat MS 3Health News:Easter Seals Awards State and Municipal Public Officials With 2007 Outstanding Advocate Awards 2Health News:oh2 Medical Spa and Vein Removal Center Set to Open Doors in December 2
(Date:7/30/2014)...  Hospira, Inc. (NYSE: HSP ), ... infusion technologies, today reported results for the second ... the quarter were $1.1 billion and adjusted* diluted ... specified items as described later in this press ... Generally Accepted Accounting Principles (GAAP) basis, second-quarter 2014 ...
(Date:7/30/2014)... SAN ANTONIO , July 30, 2014 /PRNewswire/ ... technology company focused on innovating lifesaving devices and ... closed $4.5 million in Series A financing, which ... .  Proceeds from the deal will allow Bluegrass ... Inside-Out Access Catheter System, enhance manufacturing capabilities, and ...
(Date:7/30/2014)... , July 30, 2014  PDL BioPharma, Inc. (PDL) ... management will participate in the Jefferies 2014 Boston Healthcare ... Massachusetts. The conference will occur on August 6, 2014 and ... Inc. PDL BioPharma manages a portfolio of ... et al. antibody humanization patents and license agreements with ...
Breaking Medicine Technology:Hospira Reports Second-Quarter 2014 Results 2Hospira Reports Second-Quarter 2014 Results 3Hospira Reports Second-Quarter 2014 Results 4Hospira Reports Second-Quarter 2014 Results 5Hospira Reports Second-Quarter 2014 Results 6Hospira Reports Second-Quarter 2014 Results 7Hospira Reports Second-Quarter 2014 Results 8Hospira Reports Second-Quarter 2014 Results 9Hospira Reports Second-Quarter 2014 Results 10Hospira Reports Second-Quarter 2014 Results 11Hospira Reports Second-Quarter 2014 Results 12Hospira Reports Second-Quarter 2014 Results 13Hospira Reports Second-Quarter 2014 Results 14Hospira Reports Second-Quarter 2014 Results 15Hospira Reports Second-Quarter 2014 Results 16Hospira Reports Second-Quarter 2014 Results 17Hospira Reports Second-Quarter 2014 Results 18Hospira Reports Second-Quarter 2014 Results 19Hospira Reports Second-Quarter 2014 Results 20Hospira Reports Second-Quarter 2014 Results 21Hospira Reports Second-Quarter 2014 Results 22Hospira Reports Second-Quarter 2014 Results 23Hospira Reports Second-Quarter 2014 Results 24Hospira Reports Second-Quarter 2014 Results 25Hospira Reports Second-Quarter 2014 Results 26Hospira Reports Second-Quarter 2014 Results 27Hospira Reports Second-Quarter 2014 Results 28Hospira Reports Second-Quarter 2014 Results 29Hospira Reports Second-Quarter 2014 Results 30Hospira Reports Second-Quarter 2014 Results 31Bluegrass Vascular Technologies Raises $4.5M Series A Financing Led By Targeted Technology Funds 2PDL BioPharma to Participate in Jefferies 2014 Boston Healthcare Summit 2
... Dec. 14 Cardinal Health today announced that executives of the ... Goldman Sachs CEO Unplugged Conference on Jan. 6 at Noon ... 28th Annual J.P. Morgan Healthcare Conference on Jan. 12 ... Francisco. , At these events, company executives will discuss Cardinal ...
... , STAMFORD, Conn., Dec. 14 Zargis ... SPDE ) and a spin-off from Siemens Corporate Research (NYSE: ... selling its award-winning Zargis Cardioscan(TM) system on Amazon.com, America,s largest ... were jointly named Popular Science magazine,s ...
Cached Medicine Technology:Cardinal Health Executives to Speak at Two Investor Events in January 2Zargis Cardioscan 'The Intelligent Stethoscope' Now Available on Amazon.com 2
Liquid, ready-to-use, bar-coded Olympus reagents are convenient, economical easy-to-use and reliable. This is one of 122 tests standardized for use on the Olympus AU400e, AU640e, AU2700, and AU5400 C...
The pediatric blanket provides full coverage for pediatric patient care. The generous size and versatility of these blankets include extra material for the shoulders and feet. The foot drape also red...
Cocoon Disposable Patient Warming Blankets are specially designed to prevent hypothermia and maintain normothermia in your patients. The soft warm coloured material is strong and resists tearing and ...
The design of the large pediatric underbody blanket conveniently warms the large child or small adult patient while allowing full access for surgeons and staff....
Medicine Products: