Navigation Links
Turning Alzheimer's fuzzy signals into high definition
Date:5/7/2013

double every 20 years, leading to more than 115 million cases by 2050. Of the five pharmaceuticals approved to treat the disease by the U.S. Food and Drug Administration, four are cholinesterase inhibitors. Although it is clear that the drugs increase the amount of acetylcholine in the brain, why this improves Alzheimer's symptoms has been unknown. If scientists understood the mechanisms and pathways responsible for improvement, they might be able to tailor better drugs to combat the disease, which costs more than $200 billion annually in the United States alone.

In the new study, Moran recruited 13 healthy young adults and gave them doses of galantamine, one of the cholinesterase inhibitors commonly prescribed to Alzheimer's patients. Two electroencephalographs were taken one with the drugs and one without as the participants listened to a series of modulating tones while focusing on a simple concentration task.

The researchers were looking for differences in neural activity between the two drug states in response to surprising changes in the sound patterns that the participants were hearing.

The scientists compared the results with computer models built on a Bayesian brain theory, known as the Free Energy Principle, which is a leading theory that describes the basic rules of neuronal communication and explains the creation of complex networks.

The theory hypothesizes that neurons seek to reduce uncertainty, which can be modeled and calculated using free energy molecular dynamics. Connecting tens of thousands of neurons behaving in this manner produces the probability machine that we call a brain.

Moran and her colleagues compiled 10 computer simulations based on the different effects that the drugs could have on the brain. The model that best fit the results revealed that the low-level wheels of the brain early on in the neural networking process were the ones benefitting from the drugs and creating clearer, more pr
'/>"/>

Contact: Paula Byron
paulabyron@vt.edu
540-526-2027
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Coffee may help prevent breast cancer returning, study finds
2. Anesthesia increases success rates of turning breech babies, reduces delivery costs
3. As Economy Rebounds, More Folks Try Turning Back Hands of Time
4. Turning repulsive feelings into desires
5. Turning Tragedy Into Hope for Others With Spinal Cord Injury
6. Inside a machine for turning coffee into science
7. Yumi Media Commented on an Article That Says Turning Vegetarian Helps You Discover New Recipes
8. AuDNet Pushes for Professional Hearing Tests for All Troops Returning from the Middle East.
9. Quorn Foods Inc. Releases a Statement Regarding the News of Meat Eaters Turning to Meatless Meals When Dining
10. 1 in 4 in U.S. Starts Drinking Before Turning 21: Report
11. Time Change Means Turning Clocks Back on Sunday
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... , A mathematical model developed by NIH grantees predicts ... to prevent HIV infection via vaginal sex, whereas just ... infection via anal sex. This finding helps explain why ... PrEP, in women failed to show efficacy. Participants in ... of Truvada and tenofovir (another antiretroviral) for HIV prevention ...
(Date:10/30/2014)... 30, 2014 Graphics, coding, typography and ... with the craft of web design and require thorough ... a simpler solution to create a website can be ... contact information, customer reviews and Facebook posts all accumulate ... is the next evolution of how a business can ...
(Date:10/30/2014)... Portland, OR (PRWEB) October 30, 2014 ... law firm Hodgkinson Street LLC announces new branding ... Hodgkinson Street Mepham . After David Mepham’s promotion ... revitalizes their brand and website to include Mepham’s name ... leading medical malpractice and mediation firm, the decision to ...
(Date:10/30/2014)... Radio listeners who indicate use of four ... of traditional radio commercials and have overwhelmingly endorsed custom ... a purchasing decision. , Those are some highlights from ... radio marketing company CRN International. The research is now ... respondents who indicated they have purchased or considered purchase ...
(Date:10/30/2014)... Dennis Thompson HealthDay Reporter ... Ebola outbreak in Liberia -- one of three West African ... Health Organization officials said Wednesday. Dr. Bruce Aylward, WHO,s ... number of burials in Liberia and no increase in laboratory-confirmed ... push to tame the epidemic may be making some progress, ...
Breaking Medicine News(10 mins):Health News:Model by NIH grantees explains why HIV prevention dosing differs by sex 2Health News:Facebook Websites In Thirty-Seconds 2Health News:Hodgkinson Street Mepham Rebrands 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 3Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 3
... Tripura Medical College Sunday here to become the ... region. ,"Tripura Medical College, promoted by ... state government, is the first public private partnership ... said K. Balachandran Nair, chairman-cum-managing director, Universal Empire ...
... Quebec coroner Jacques Ramsay has recommended that Canadians suffering ... (epinephrine) or the Twinject, which// provides a double dose ... deadly situations. He has also called for ... to the patients. ,The recommendations follow the ...
... H5N1 virus in a small duck farm in the southern ... ,An animal health official from Thach Phu district, Ben Tre ... had the H5N1 virus." All 84 ducks on the ... 14 nearby farms tested negative for the virus. ...
... 22 organizations have joined hands, formalizing their consent to ... in the working environment. ,Teaming up ... has been conducting workshops for the companies that believe ... of the national business council is also on the ...
... British Heart Foundation (BHF) suggested that people with advanced heart ... their real age.// ,In ... tissues from heart bypass and transplant patients to study how ... the artery cells divide seven to 13 times more rapidly ...
... University, English cider apples have high levels of phenolics – ... ,Thus, a pint of cider is as effective ... to test cider’s effects by getting 12 volunteers to drink ... of cider in a controlled environment and avoid antioxidants in ...
Cached Medicine News:
(Date:10/31/2014)... -- Migranade, Inc. announced today the new migraine medication, ... million U.S. migraine sufferers November, 2014. The medicine is ... cause of migraines and not just the symptoms. While ... Migranade is assured to be a game changer in ... at http://www.migranade.com and will soon hit the ...
(Date:10/31/2014)... , Oct. 31, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ...  What: , Isis Pharmaceuticals, Third Quarter 2014 ... November 7 at 11:30 a.m. ET / 8:30 a.m. ... on the Internet. Simply log onto our website listed ... live event, a replay of the webcast will be ...
(Date:10/30/2014)... CHARLOTTETOWN , Oct. 30, 2014 /CNW/ - Atlantic ... three-year agreement reached between Canada,s ... Jim Keon , President of the Canadian Generic Pharmaceutical ... made the comments while speaking at the Atlantic Summit ... Charlottetown , which is being hosted by the ...
Breaking Medicine Technology:Game Changing Migraine Medication To Be Available November 2014 2Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 2Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 3Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 3
... Texas, Sept. 29 Luminex Corporation (Nasdaq: ... 2010 Prix Galien USA Award for its innovative xTAG® ... named Best Medical Technology at the Prix Galien USA ... 2010, at the American Museum of Natural History in ...
... asked today to make protecting the eyes from ... by increasing the prevalence of UV and eye-health ... as the Surgeon General, and in upcoming healthcare ... the Congressional Vision Caucus, provided the opening remarks ...
Cached Medicine Technology:Luminex Corporation Wins Prestigious 2010 Prix Galien USA Award 2Prevent Blindness America Issues Call-to-Action to Make UV Eye Protection a National Health Priority 2Prevent Blindness America Issues Call-to-Action to Make UV Eye Protection a National Health Priority 3
... excellent illumination (150'000 to approx. 600'000 ... length of the slit image either ... to 8 mm respectively 1 to ... allowing hairline settings providing unique depth ...
... The AQT-10 is the ultimate in clinical ... to detect the subtle red/green or blue/yellow ... as retinal toxicity (that from Plaquenil, for ... and macular degeneration. Additionally it is fast ...
... The UTAS-E 3000 is the most ... rapid and accurate measurements of retinal ... comprehensive, easy-to-use software available drives this ... such as adjustable contrast pattern stimulation, ...
... VEP technology is designed for productivity and ease ... with doctors from the University of Wisconsin who ... decade on over 5,000 subjects. All of the ... and stored, or can be preset and loaded ...
Medicine Products: