Navigation Links
Turmeric extract suppresses fat tissue growth in rodent models

BOSTON (May 18, 2009) Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue in mice and cell models. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA) studied mice fed high fat diets supplemented with curcumin and cell cultures incubated with curcumin.

"Weight gain is the result of the growth and expansion of fat tissue, which cannot happen unless new blood vessels form, a process known as angiogenesis." said senior author Mohsen Meydani, DVM, PhD, director of the Vascular Biology Laboratory at the USDA HNRCA. "Based on our data, curcumin appears to suppress angiogenic activity in the fat tissue of mice fed high fat diets."

Meydani continued, "It is important to note, we don't know whether these results can be replicated in humans because, to our knowledge, no studies have been done."

Turmeric is known for providing flavor to curry. One of its components is curcumin, a type of phytochemical known as a polyphenol. Research findings suggest that phytochemicals, which are the chemicals found in plants, appear to help prevent disease. As the bioactive component of turmeric, curcumin is readily absorbed for use by the body.

Meydani and colleagues studied mice fed high fat diets for 12 weeks. The high fat diet of one group was supplemented with 500 mg of curcumin/ kg diet; the other group consumed no curcumin. Both groups ate the same amount of food, indicating curcumin did not affect appetite, but mice fed the curcumin supplemented diet did not gain as much weight as mice that were not fed curcumin.

"Curcumin appeared to be responsible for total lower body fat in the group that received supplementation," said Meydani, who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts. "In those mice, we observed a suppression of microvessel density in fat tissue, a sign of less blood vessel growth and thus less expansion of fat. We also found lower blood cholesterol levels and fat in the liver of those mice. In general, angiogenesis and an accumulation of lipids in fat cells contribute to fat tissue growth."

Writing in the May 2009 issue of the Journal of Nutrition, the authors note similar results in cell cultures. Additionally, curcumin appeared to interfere with expression of two genes, which contributed to angiogenesis progression in both cell and rodent models.

"Again, based on this data, we have no way of telling whether curcumin could prevent fat tissue growth in humans." Meydani said. "The mechanism or mechanisms by which curcumin appears to affect fat tissue must be investigated in a randomized, clinical trial involving humans."


Contact: Andrea Grossman
Tufts University, Health Sciences

Related medicine news :

1. The Center for the Biology of Chronic Disease Highlights Anti-Cancer Activities of the Food Extracts Quercetin, EGCG, Glycyrrhizin, and Trans-Cinnamaldehyde
2. No Verdict Yet on Grape Seed Extract vs. Breast Cancer
3. The navel: A single, safe surgical access route for kidney extraction
4. Grape Seed Extract Kills Leukemia Cells in Lab
5. Canadian study of colds and kids: Positive safety results for ginseng extract
6. Release of Kowalski Book on Attaining Healthy Blood Pressure Coincides with Website Launch, New Endurance Products SR L-Arginine and Grape Seed Extract
7. Study indicates grape seed extract may reduce cognitive decline associated with Alzheimers disease
8. Licorice extract provides new treatment option for canker sores
9. MIPSolutions, Inc. Reduces Expense and Development Time Associated With Precious Metal Extraction
10. New findings: The anti-fibrotic mechanism of plant extract Cpd 861
11. Green Tea, Mushroom Extract Combo Slows Sarcomas
Post Your Comments:
(Date:11/30/2015)... ... 30, 2015 , ... GKhair & Tibolli team members and artists were excited ... on November 8th and 9th at the Puerto Rico Convention Center, San Juan Puerto ... and top of the line fashion journalists. The San Juan Beauty Show carries immense ...
(Date:11/30/2015)... ... November 30, 2015 , ... Winscribe ... at the Radiological Society of North America (RSNA) 2015 conference. , Leading ... cutting-edge dictation and speech-enabled documentation software, announced their partnership today at RSNA ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... announces the Unstoppable Swappables, a household invention that provides an economical and easy ... a year and is growing at 2.6%," says Scott Cooper, CEO and Creative ...
(Date:11/29/2015)... ... November 29, 2015 , ... ... Institute of Ultrasound in Medicine! , AIUM ultrasound practice accreditation is a ... or exceed nationally recognized standards in the performance and interpretation of diagnostic ...
(Date:11/29/2015)... Ca (PRWEB) , ... November 29, 2015 , ... Khanna ... American Board of Ophthalmology on November 25th 2015. Peer Certification by the ... field of his specialty. Certification in Ophthalmology is first obtained after the completion of ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 Un nuevo enfoque ... para el cáncer avanzado.   --> ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... inmunoterapia con la terapia fotodinámica de Bremachlorin para el ... . --> Clinical Cancer Research . ...
(Date:11/26/2015)... 26, 2015 --> ... SyMRI to find optimal contrast weighting of MRI for ... has signed a research agreement with SyntheticMR in order to ... SyMRI, it is possible to generate multiple contrast images from ... patient has left, thus making it possible to both fine ...
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
Breaking Medicine Technology: