Navigation Links
Tumors with ALK rearrangements can harbor more mutations
Date:4/22/2013

DENVER The identification of potentially targetable kinase mutations has been an exciting advancement in lung cancer treatment. Although the mutations driving many lung carcinomas remain unknown, approximately 50 percent of lung adenocarcinoma cases harbor KRAS mutation, EGFR mutation, or ALK translocation, and an additional 5 percent or so have been shown to have mutations involving BRAF, PIK3CA, HER2, MET, MEK1, NRAS, and AKT. In the vast majority, these driver mutations are mutually exclusive. But in a recent study published in the International Association for the Study of Lung Cancer's Journal of Thoracic Oncology (JTO) researchers have found that tumors with ALK rearrangements can harbor additional mutations.

Researchers looked at 25 cases of pulmonary adenocarcinoma surgically treated at Mayo Clinic between 1999 and 2007 with ALK gene rearrangement, confirmed by break-apart fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC). Using the DNA extracted from formalin-fixed paraffin-embedded tumor samples, a MassArray-based Lung Cancer Mutations Screening Panel was performed to test for 179 individual mutations in 10 genes, with positive results confirmed by sequencing.

They found additional mutations in 5 of 25 (20 percent) of ALK positive cases. Four of these were point mutation in the MET gene that are of unknown clinical significance, since they may represent germline polymorphisms. However, one case had an EGFR mutation, further supporting that EGFR mutations can be present in ALK rearranged tumors, although it is rare.

"Much is yet to be learned about treatment of patients with both ALK rearrangement and EGFR mutation," the authors report. "Although some of these patients have had a good response to the EGFR inhibitors erlotinib and gefitinib, one patient reportedly showed resistance to erlotinib. Further research is needed to determine if patients with coexisting EGFR mutation and ALK gene rearrangement
'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Wayne State researchers seek calcium channels to target cancer tumors
2. Hundreds of alterations and potential drug targets to starve tumors identified
3. Hundreds of alterations and potential drug targets to starve cancer tumors identified
4. Chemical shift MRI helps differentiate renal cell tumors more likely to metastasize
5. Virus-like particles provide vital clues about brain tumors
6. Freezing Treatment May Help Destroy Lung Tumors: Study
7. Electrical pulse treatment pokes holes in hard-to-treat tumors
8. AACR: Positive data supports advancing BIND-014 to phase 2 clinical trials for solid tumors
9. Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination
10. Different drug combinations work best for prevention versus treatment of colorectal tumors
11. Engineered T cells kill tumors but spare normal tissue in an animal model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... (PRWEB) May 26, 2015 Many ... added to TheCelebrityDresses.com's formal dress collections recently. Now, ... newly designed dresses, up to 70% off. The ... the world to save hundreds of dollars on ... well-known brand in red carpet fashion special occasion ...
(Date:5/26/2015)... 26, 2015 Pacifica Graduate ... the Memorial Day weekend, celebrating the outstanding accomplishments ... Pacifica’s picturesque Ladera Lane campus, located in the ... alumni traveled to Santa Barbara from all over ... , The 2015 commencement ceremonies featured the ...
(Date:5/26/2015)... Marietta, GA (PRWEB) May 26, 2015 ... Dental Associates are at it again, helping local rescue ... 25, 2015. Local dentists, Kirk Kimmerling DDS, Suzanna ... with veterinarian, Julian Peckich DVM donating 100% of proceeds ... expected to fill the parking lot to help save ...
(Date:5/25/2015)... SAN FRANCISCO (PRWEB) May 26, 2015 According ... people has retinitis pigmentosa , a degenerative eye disease. ... every 150,000 people has paroxysmal kinesigenic dyskinesia , a ... For author Joseph K. Chan , these two diseases ... Chan invites readers to walk in his shoes with his ...
(Date:5/25/2015)... 26, 2015 The National ... Dr. Heather Stanley-Christian as a 2015-2016 inductee ... She is recognized with this prestigious distinction for ... networking organization exclusively for professional women, boasting more ... chapters. , "I'm pleased to welcome Heather into ...
Breaking Medicine News(10 mins):Health News:Cocktail Dresses Inspired by Celebrities on Sale at TheCelebrityDresses.com 2Health News:Pacifica Graduate Institute Hosted its 2015 Commencement Ceremonies over Memorial Day Weekend 2Health News:Pacifica Graduate Institute Hosted its 2015 Commencement Ceremonies over Memorial Day Weekend 3Health News:"Rescue Animal Cookout" Announced at Verde Pointe Professional Park on June 25, 2015 2Health News:Joseph K. Chan Finds Faith from Disability in New Autobiography 2Health News:NAPW Inducts Dr. Heather Stanley-Christian, Systems Chair/Maternal Fetal Medicine at Stroger Hospital, into Its VIP Professional Woman of the Year Circle 2
... study, vertical work-stations, incorporating a treadmill, could help obese employees shed ... ,The vertical walk and work desk allows people to work at ... of their own choosing. ,Designed by the authors, the ... the alphabet H and held by four locking rubber wheels, so ...
... According to researchers from the United States, anxiety appears to increase ... coronary artery disease. ,Coronary artery disease is caused ... supply oxygen and blood to the heart. This causes them ... to heart attack, angina (chest pain) and other serious complications. ...
... has found a solution for the embarrassing problem of bad ... a mouth paste that can tackle separate causes of smelly ... such as dihydrogen sulphide, which can lead to bad breath, ... has an enzyme that fights starch and cellulose in between ...
... less likely to receive several types of routine outpatient ... , according to a RAND Corporation study issued today. ... less frequently receive expensive medical care such as angioplasty ... in managed care settings. ,All the patients ...
... that polyphenols, dietary substances from vegetables, fruits and green ... by increasing the fatty acid breakdown and influence ... stimulate energy-sensing regulatory protein SIRT1. ,Polyphenols are ... and vegetables. Due to their possible health effect, polyphenols ...
... smokeless cannabis-vaporizing device delivers the same level of active ... smoking cannabis , but without the harmful toxins, according ... study, which focuses on delivery of the active ingredient ... of the journal "Clinical Pharmacology and Therapeutics." ...
Cached Medicine News:Health News:walk and Work Desk Could Help Obese Workers to Shed Weight 2Health News:Dont Worry- Be Good To Your Heart 2Health News:Women With Heart Disease and Diabetes Less Likely to Receive Proper Care: Study 2Health News:Women With Heart Disease and Diabetes Less Likely to Receive Proper Care: Study 3Health News:Intake of Polyphenol Speeds Up Fatty Acid Catabolism 2Health News:Smokeless Cannabis Delivery Device Found Efficient and Less Toxic 2
(Date:5/26/2015)... British Columbia , May 26, 2015 /PRNewswire/ ... announced today that it has filed a provisional ... Trademark Office ("USPTO") relating to the treatment of ... natural cannabinoid compounds developed by InMed. ... Chief Scientific Officer, commented, "We are excited to ...
(Date:5/22/2015)... 22, 2015  Research and Benchmarking firm, Best ... Medical Affairs Roundtable on Thursday, May 28th ... roundtable to discuss "Medical Affairs, Role in Health ... Medical Affairs Consortium provides Medical Affairs leaders with ... challenges they face. The consortium has developed a ...
(Date:5/22/2015)... mayo de 2015 Dipexium Pharmaceuticals, ... farmacéutica de fase tardía centrada en el ... 0.8%), y colaboradores de investigación clínica, han ... el diseño innovador de los ensayos pivotales ... evalúan Locilex®, su nuevo péptido de antibiótico ...
Breaking Medicine Technology:InMed Pharmaceuticals Files Provisional Patent Covering Novel Compounds for Treating Epidermolysis Bullosa Simplex (EBS) 2InMed Pharmaceuticals Files Provisional Patent Covering Novel Compounds for Treating Epidermolysis Bullosa Simplex (EBS) 3Best Practices Sixth Medical Affairs Consortium Roundtable to Focus on Health Economics & Outcomes Research 2Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 2Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 3Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 4Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 5Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 6
Sandhill Scientific offers a comprehensive selection of solid state and water perfused catheters for both adult & pediatric applications.Contact Sandhill Scientific for full details...
... water perfused manometric catheters for ... diagnostic tests. All Medtronic Water ... clear, medical grade PVC tubing. ... esophagus you will find a ...
Esophageal Stylet for LATITUDE® Air-Charged Catheter...
Anorectal Stylet for LATITUDE® Air-Charged Catheter...
Medicine Products: