Navigation Links
Tumors use enzyme to recruit regulatory T-cells and suppress immune response
Date:8/16/2007

One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.

It was known tumors assemble a protective barrier of regulatory T cells, or Tregs, but how they are such able recruiters was an unknown, says Dr. David Munn, pediatric hematologist/oncologist at the Medical College of Georgia Cancer Center.

People have been very interested in how the tumor gets so many of these cells and how they get activated so they tend to be very aggressive, more suppressive in the tumor than they appear to be elsewhere in the body, Dr. Munn says of Tregs, major players in preventing autoimmune diseases such as arthritis and type 1 diabetes, where the immune system attacks body tissue.

Research published online Aug. 16 in The Journal of Clinical Investigation shows IDO, which seems to play a powerful role in tumor survival despite the relatively few number of cells in the tumors draining lymph nodes, directly activates existing Tregs which become strongly suppressive within a day. The number doesnt change a lot, but their activation state changes hugely, says Dr. Munn, corresponding author.

Studies in a tumor animal model show this rapid conversion occurs only in lymph nodes connected to tumors.

The findings further define a tumors survival strategy of first recruiting IDO, which helps recruit Tregs. Tregs then up-regulate the PD-L1/PD-L2 pathway, which has been shown to play an important role in the immune suppression caused by AIDS.

For the first time it creates a link between IDO, regulatory T cells and this novel pathway we dont know much about, says Dr. Munn. Interestingly its a link that appears to come full circle because, as researchers at the University of Perugia in Italy showed in 2003, in the test tube at least, Tregs also help recruit more IDO.


'/>"/>
Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Radiofrequency Energy Cooks Tumors Without Surgery
3. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
4. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
5. New Technique For Benign Breast Tumors
6. Morphine may excite cancerous tumors
7. Benign eye tumors being treated
8. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
9. Same molecule found in meat, milk, tumors
10. Another Treatment Option for Benign Tumors
11. Understanding The Origin Of Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... The WeedLife Network has come up ... has been troubling cannabis businesses with their online ... the launch of WeedLIVE, the first-ever cannabis website ... launched today, WeedLIVE.com is designed specifically for the ... marijuana-related business websites. , WeedLIVE deals directly with ...
(Date:4/27/2015)... York, NY (PRWEB) April 27, 2015 ... economist and philanthropist Sanford J. Grossman, PhD, has committed ... Center for Integrative Studies in Inflammatory Bowel Disease at ... Center will focus on creating personalized medicine for treatment ... and predicting disease progression. , Crohn’s Disease, a chronic ...
(Date:4/27/2015)... VA (PRWEB) April 27, 2015 The ... leader in providing members with applied business information and ... Washington Insider,” a weekly email newsletter for its more ... from existing health care legislative news sources in that ... relevant to the business of radiology. The newsletter is ...
(Date:4/27/2015)... 27, 2015 Winscribe Professional for ... suite of mobile speech productivity technology, which also ... and smartphones. , Winscribe has supported ... since 2005. With the latest enhancement, Winscribe ... mobile application interface in the last ten years. ...
(Date:4/27/2015)... IL (PRWEB) April 27, 2015 Pure ... launch of its brand new website design at ... list of the company’s product catalog, both featured and ... Natural blog ( http://www.purennatural.com/blog/ ). , Pure n Natural ... and satisfying shopping experience. The website is neatly organized ...
Breaking Medicine News(10 mins):Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 2Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 3Health News:Sanford J. Grossman Charitable Trust Pledges $3 Million to Create Center at Mount Sinai 2Health News:Sanford J. Grossman Charitable Trust Pledges $3 Million to Create Center at Mount Sinai 3Health News:Radiology Business Management Association Launches Weekly Legislative and Policy Newsletter 2Health News:Winscribe Professional Dictation for Smartphones Evolves as Microsoft’s Mobile OS Grows 2Health News:Winscribe Professional Dictation for Smartphones Evolves as Microsoft’s Mobile OS Grows 3Health News:Winscribe Professional Dictation for Smartphones Evolves as Microsoft’s Mobile OS Grows 4Health News:Pure n Natural Systems, Inc. Launches New Website Design 2Health News:Pure n Natural Systems, Inc. Launches New Website Design 3
... illusion; ridiculous, says former star major league pitcher , FRIDAY, ... the pitcher,s hand. In less than a second, it curves ... , The curveball, when thrown correctly, is one of baseball,s ... and not so great have sworn that the ball seems ...
... FRANCISCO, Calif., Oct. 30 Anesiva, Inc. (Nasdaq: ANSV ... Stockholders will be held on December 3, 2009 at 9:00 ... Francisco, California. Stockholders of record at the close of ... at the 2009 Annual Meeting of Stockholders. The definitive ...
... (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, ... Tablets, at a major psychiatric medical meeting today. ... the change from baseline on the oppositional subscale of ... in patients ages 6 to 12 with a primary ...
... around right after procedure cuts conception rate, study found ... lie flat for 15 minutes after being artificially inseminated ... suggests. , "Allowing women treated for subfertility with IUI ... a 50 percent higher chance at conceiving," said Inge ...
... ... joined the crusade to better our environment by offering green printing services and eco-friendly ... information for the company,s custom labels offering. , ... Fort Scott, KS (PRWEB) October 30, 2009 --, , ...
... infants, studies show , FRIDAY, Oct. 30 (HealthDay ... who should get H1N1 swine flu and seasonal flu ... vaccination for moms-to-be and their babies. , Bigger, healthier ... top the findings, which are to be presented this ...
Cached Medicine News:Health News:Scientist Throws Curve Into Breaking-Ball Debate 2Health News:Scientist Throws Curve Into Breaking-Ball Debate 3Health News:Anesiva Announces Date for 2009 Annual Meeting of Stockholders to Vote on Proposed Merger 2Health News:Anesiva Announces Date for 2009 Annual Meeting of Stockholders to Vote on Proposed Merger 3Health News:INTUNIV demonstrated symptom reduction on oppositional subscale Conners' ADHD rating scale 2Health News:INTUNIV demonstrated symptom reduction on oppositional subscale Conners' ADHD rating scale 3Health News:Lying Still Raises Artificial Insemination Success 2Health News:Lying Still Raises Artificial Insemination Success 3Health News:My1Stop.com Launches New Custom Labels Solutions Making Pricing and Ordering Faster and Easier 2Health News:Flu Shot in Pregnancy Protects Baby 2Health News:Flu Shot in Pregnancy Protects Baby 3
(Date:4/27/2015)... , April 27, 2015 BioLife ... developer, manufacturer and marketer of proprietary clinical grade ... and precision thermal shipping products for cells ... the United States Food and Drug Administration has confirmed ... Thawing Media products.  While not an endorsement nor approval ...
(Date:4/27/2015)... -- TWi Pharmaceuticals, Inc. ("TWi") today announced that ... Takeda Pharmaceutical Company Limited, Takeda Pharmaceuticals ... (individually and collectively, "Takeda") to settle and dismiss ... dexlansoprazole delayed release capsules for oral administration in ... New Drug Application for TWi,s generic product is ...
(Date:4/26/2015)... 2015  Ikonopedia announced today that its breast ... been selected for use by BelleBridge, which provides ... diagnostic examinations. Ikonopedia will showcase its suite of ... Imaging,s SBI/ACR Breast Imaging Symposium in ... Booth #216). BelleBridge is an innovative ...
Breaking Medicine Technology:BioLife Solutions Submits FDA Master Files for Cell Thawing Media Products 2BioLife Solutions Submits FDA Master Files for Cell Thawing Media Products 3BioLife Solutions Submits FDA Master Files for Cell Thawing Media Products 4TWi Announces Settlement with Takeda on Dexilant(R) Litigation 2Ikonopedia Selected to Provide Breast Imaging Report Generation Capabilities for BelleBridge's Breast Telemedicine Services 2Ikonopedia Selected to Provide Breast Imaging Report Generation Capabilities for BelleBridge's Breast Telemedicine Services 3Ikonopedia Selected to Provide Breast Imaging Report Generation Capabilities for BelleBridge's Breast Telemedicine Services 4
... Calif., March 31, 2011 NewCardio, Inc., (OTC Bulletin ... developer, announced today that the Company has been invited ... performance study at an upcoming conference entitled "Cardiovascular Safety ... Food and Drug Administration (FDA), the Cardiac Safety Research ...
... 31, 2011 The U.S. Department of Energy has ... field of medical technology and innovation for commercializing the ... agency, Dilon and similar entrepreneurs, "build the new industries ... our toughest global challenges." The Dilon 6800® ...
Cached Medicine Technology:NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 2NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 3NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 4NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 5NewCardio Invited to Present Latest QTinno Performance Improvements at FDA-Sponsored Conference on Cardiovascular Safety in Drug Development 6U.S. Department of Energy Hails Dilon Diagnostics as a Medical Technology Pioneer and Top National Innovator 2
...
... control panel with 3 charging wells. Available ... Colonial Blue and Cinnamon. Spring balanced refractor ... and steel construction for lifelong quality. Sealed ... up/down chair movement. Chair back reclines manually ...
... Ophthalmics™ Balanced Salt Solution (Sterile Irrigating ... physiologic solution which is isotonic to ... for normal cellular metabolic functions. Each ... (CaCl22H2O), USP .48 mg, Magnesium Chloride ...
3.5v Ophthalmic Diagnostic Set with AutoStep Coaxial Ophthalmoscope, Spot Retinoscope, Rechargeable Handle, and Soft Case. High-quality eyecare from the preferred name in diagnostic instruments....
Medicine Products: