Navigation Links
Tumors use enzyme to recruit regulatory T-cells and suppress immune response
Date:8/16/2007

One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.

It was known tumors assemble a protective barrier of regulatory T cells, or Tregs, but how they are such able recruiters was an unknown, says Dr. David Munn, pediatric hematologist/oncologist at the Medical College of Georgia Cancer Center.

People have been very interested in how the tumor gets so many of these cells and how they get activated so they tend to be very aggressive, more suppressive in the tumor than they appear to be elsewhere in the body, Dr. Munn says of Tregs, major players in preventing autoimmune diseases such as arthritis and type 1 diabetes, where the immune system attacks body tissue.

Research published online Aug. 16 in The Journal of Clinical Investigation shows IDO, which seems to play a powerful role in tumor survival despite the relatively few number of cells in the tumors draining lymph nodes, directly activates existing Tregs which become strongly suppressive within a day. The number doesnt change a lot, but their activation state changes hugely, says Dr. Munn, corresponding author.

Studies in a tumor animal model show this rapid conversion occurs only in lymph nodes connected to tumors.

The findings further define a tumors survival strategy of first recruiting IDO, which helps recruit Tregs. Tregs then up-regulate the PD-L1/PD-L2 pathway, which has been shown to play an important role in the immune suppression caused by AIDS.

For the first time it creates a link between IDO, regulatory T cells and this novel pathway we dont know much about, says Dr. Munn. Interestingly its a link that appears to come full circle because, as researchers at the University of Perugia in Italy showed in 2003, in the test tube at least, Tregs also help recruit more IDO.


'/>"/>
Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Radiofrequency Energy Cooks Tumors Without Surgery
3. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
4. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
5. New Technique For Benign Breast Tumors
6. Morphine may excite cancerous tumors
7. Benign eye tumors being treated
8. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
9. Same molecule found in meat, milk, tumors
10. Another Treatment Option for Benign Tumors
11. Understanding The Origin Of Tumors

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/9/2009).../ -- The Churchill Centre today announced that i... "Bill" Marriott for his lifelong commitment to pr...practices and fostering an open and transparent gl...is award at a ceremony and dinner on Tuesday, Nove... ,, "This is a testament to how Bill Marriott ...
(Date:11/9/2009)...qually, study finds, , , MONDAY, Nov. 9...ng drug Plavix (clopidogrel) works about the same ...trials has found. , "After this study, I can sa...en with this very important drug," said Dr. Jeffre... at New York University Langone Medical Center in ...
(Date:11/9/2009)...s in mood despite similar weight loss , ,...at, low-carbohydrate diet such as the popular Atki... help people lose pounds over the course of a year...ll result in long-term improvement in mood, accord... Internal Medicine . , People on both diets con...
(Date:11/9/2009)...ay be too late when it comes to preventing or impr..., Inc. (Take Off Pounds Sensibly), the nonprofit w... (Vocus) November 9, 2009 -- Tomorrow may...ing a diabetes condition, according to TOPS Club, ...ght-loss support organization., , ,Diabetes is a d...
(Date:11/9/2009)...wire/ -- Health Connect Partners, Inc., ( www.hlt...gural Hospital O.R. and Surgery Center Conference ... Hotel in Nashville, Tenn. ,, Health Connect Pa...ng room directors and managers from some of the la... Some of the confirmed providers include HCA, Bon ...
Breaking Medicine News(10 mins):Health News:J.W. 'Bill' Marriott to Receive Churchill Centre Award For Leadership 2Health News:No Gender Gap Found for Clot-Busting Drug 2Health News:No Gender Gap Found for Clot-Busting Drug 3Health News:To Feel Better, Low-Fat Diet May Be Best 2Health News:To Feel Better, Low-Fat Diet May Be Best 3Health News:Diabetes Prevention Is the Best Remedy, TOPS Medical Expert Says 2Health News:Diabetes Prevention Is the Best Remedy, TOPS Medical Expert Says 3Health News:Health Connect Partners Hosts Hospital O.R. & Surgery Center Conference 2
...ANSING, Mich., May 12 Michael A.,Sandler, MD, a W...ed as,president of the 15,000 member Michigan Stat...eeting of the MSMS House of Delegates on May 3 in,...enry,Ford Hospital and currently serves on the Mic...
...Partners hosts nine physicians from Chongqing Bure...artners,Institute for Medical Education is hosting...sicians ever to visit Minnesota. During their,thre...nical research methodology., "We,re honored that ...
..., May 12 PAREXEL International,Corporation (Nasda...t the,Robert W. Baird 2008 Growth Stock Conference... President and Chief Financial Officer will be mak...Investor Relations Webcasts" section of PAREXEL,s ...
...rnia Nurses Association charged with illegally att...Iowa Caucuses for unsolicited mailers to,workers, ...ssociation (CNA) violated Iowa state law by improp...led on behalf,of nurses today. The suit charges th...
...ton, MA Innovative prism glasses can significantl...ts with hemianopia, a condition that blinds half t... glasses, which were invented by Dr. Eli Peli, a S...d in the May issue of the Archives of Ophthalmolog...
...AKE CITY, May 12 Dynatronics,Corporation (Nasdaq:...arter,ended March 31, 2008 on Wednesday, May 14, 2... for investors later that,day at 2:30 p.m. ET to d...atronics manufactures, markets and distributes adv...
Other Medicine News:Health News:Michael A. Sandler, MD, Installed as President of Michigan State Medical Society 2Health News:First Major Chinese Medical Delegation Visits Minnesota 2Health News:PAREXEL International to Present at Robert W. Baird's 2008 Growth Stock Conference 2Health News:SEIU - New Lawsuit: CNA Violated State Law in Mass Mailings to Iowa Nurses 2Health News:SEIU - New Lawsuit: CNA Violated State Law in Mass Mailings to Iowa Nurses 3Health News:Prism glasses expand the view for patients with hemianopia 2Health News:Prism glasses expand the view for patients with hemianopia 3
(Date:11/9/2009)...K, Nov. 9 Keryx Biopharm...ical company focused on the acquisition, developme...armaceutical products for the treatment of life-th...ease (the "Company"), today announced its results ..., At September 30, 2009, the Company had cash, c...
(Date:11/9/2009)...GO, Nov. 9, 2009 Arena P...ed financial results for the third quarter ended S...t loss allocable to common stockholders in the thi...share, compared to a net loss allocable to common ... million, or $0.76 per share, and a net loss alloc...
(Date:11/9/2009)...LE, Md., Nov. 9 OriGene Technologi...logy in Sweden has adopted its VERIFY Tagged Antig...ein Atlas program. This program is funded by the K...to explore the human proteome systematically using...ty mono-specific antibodies in a high throughput m...
Breaking Medicine Technology:Keryx Biopharmaceuticals, Inc. Announces Third Quarter 2009 Financial Results 2Keryx Biopharmaceuticals, Inc. Announces Third Quarter 2009 Financial Results 3Keryx Biopharmaceuticals, Inc. Announces Third Quarter 2009 Financial Results 4Keryx Biopharmaceuticals, Inc. Announces Third Quarter 2009 Financial Results 5Keryx Biopharmaceuticals, Inc. Announces Third Quarter 2009 Financial Results 6Arena Pharmaceuticals Announces Third Quarter 2009 Financial Results and Recent Developments 2Arena Pharmaceuticals Announces Third Quarter 2009 Financial Results and Recent Developments 3Arena Pharmaceuticals Announces Third Quarter 2009 Financial Results and Recent Developments 4Arena Pharmaceuticals Announces Third Quarter 2009 Financial Results and Recent Developments 5Arena Pharmaceuticals Announces Third Quarter 2009 Financial Results and Recent Developments 6Arena Pharmaceuticals Announces Third Quarter 2009 Financial Results and Recent Developments 7Arena Pharmaceuticals Announces Third Quarter 2009 Financial Results and Recent Developments 8Arena Pharmaceuticals Announces Third Quarter 2009 Financial Results and Recent Developments 9Royal Institute of Technology Adopts OriGene Over-Expression Lysates in Human Proteome Atlas Program 2HealthWell Foundation 28R 29 Appoints New Executive Director 59749 1HealthWell Foundation 28R 29 Appoints New Executive Director 59749 2If Hearing Loss is Not Treated Brain Can Forget How to Hear and Understand Speech 59746 1If Hearing Loss is Not Treated Brain Can Forget How to Hear and Understand Speech 59746 2IPRO Wins Federal Contract to Support Hospice Oversight 59743 1IPRO Wins Federal Contract to Support Hospice Oversight 59743 2
...fits , , WASHINGTON, Jan. 13 Electrical stimulat...er-like device sends pulses to electrodes implante... may hold significant benefits for those with Park...cation alone. , , That is the conclusion of resea...) and National Institutes of Health (NIH) who cond...
...GTON, Jan. 13 The Association of Clinical Researc...cal outsourcing industry to regulators, biopharmac...he U.S. and worldwide, today announced that it has... Mr. William Sharbaugh as Chair-Elect. , , Dr. W...egic Business Partnerships for Quintiles Transnati...
Other Medicine Technology:VA-NIH Study Offers Hope for Parkinson's Patients 2VA-NIH Study Offers Hope for Parkinson's Patients 3Dr. Derek Winstanly of Quintiles to Serve as 2009 ACRO Chair; Mr. William Sharbaugh of PPD to Be Chair-Elect 2
Lyphochek Quantitative Urine Control
Liquichek Whole Blood Volatiles Control
qUAntify Plus Control
Lyphochek Tumor Marker Control
Medicine Products: