Navigation Links
Tumors use enzyme to recruit regulatory T-cells and suppress immune response
Date:8/16/2007

One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.

It was known tumors assemble a protective barrier of regulatory T cells, or Tregs, but how they are such able recruiters was an unknown, says Dr. David Munn, pediatric hematologist/oncologist at the Medical College of Georgia Cancer Center.

People have been very interested in how the tumor gets so many of these cells and how they get activated so they tend to be very aggressive, more suppressive in the tumor than they appear to be elsewhere in the body, Dr. Munn says of Tregs, major players in preventing autoimmune diseases such as arthritis and type 1 diabetes, where the immune system attacks body tissue.

Research published online Aug. 16 in The Journal of Clinical Investigation shows IDO, which seems to play a powerful role in tumor survival despite the relatively few number of cells in the tumors draining lymph nodes, directly activates existing Tregs which become strongly suppressive within a day. The number doesnt change a lot, but their activation state changes hugely, says Dr. Munn, corresponding author.

Studies in a tumor animal model show this rapid conversion occurs only in lymph nodes connected to tumors.

The findings further define a tumors survival strategy of first recruiting IDO, which helps recruit Tregs. Tregs then up-regulate the PD-L1/PD-L2 pathway, which has been shown to play an important role in the immune suppression caused by AIDS.

For the first time it creates a link between IDO, regulatory T cells and this novel pathway we dont know much about, says Dr. Munn. Interestingly its a link that appears to come full circle because, as researchers at the University of Perugia in Italy showed in 2003, in the test tube at least, Tregs also help recruit more IDO.


'/>"/>
Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Radiofrequency Energy Cooks Tumors Without Surgery
3. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
4. Finasteride lowers risk of prostate cancer but increases risk of high-grade tumors
5. New Technique For Benign Breast Tumors
6. Morphine may excite cancerous tumors
7. Benign eye tumors being treated
8. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
9. Same molecule found in meat, milk, tumors
10. Another Treatment Option for Benign Tumors
11. Understanding The Origin Of Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2012)... Reporter , , TUESDAY, May 22 (HealthDay News) -- ... procedure, which involves threading a camera through the ... But a new study has found that patients ... less time-consuming CT-based colon scan. Colonoscopy ... colon cancer screening. Computed tomography (CT) colonography -- ...
(Date:5/23/2012)... ATS 2012, SAN FRANCISCO The number of viral ... in childhood, according to a new study from researchers ... infancy predicted wheezing later in childhood, this association was ... , "Viral infections in infancy, particularly rhinovirus, are thought ... but it is unclear whether this association is due ...
(Date:5/23/2012)... tiny, resilient metal wire designed to gather and compress ... severe heterogeneous emphysema, a subtype of the disease that ... to the results of a multicenter international trial conducted ... a lung volume reduction coil (LVRC), can be easily ... more invasive procedures used to improve the lung function ...
(Date:5/23/2012)... ROCHESTER, Minn. -- Mayo Clinic researchers will present ... other urological research at the annual meeting of ... Mayo Clinic urologists will also be available to ... , Mayo Clinic studies that will be presented ... negative impact on overall survival from post-prostate surgery ...
(Date:5/22/2012)... Bend, OR Bend Research Inc., a ... announced the expansion of its existing hot-melt ... an 18mm Leistritz twin-screw mixer/extruder. , ... Research,s existing 27mm Leistritz and 19mm Baker ... and continuous high-shear wet-granulation capabilities. Many projects ...
Breaking Medicine News(10 mins):Health News:Patients Prefer More Invasive Form of Colon Scan: Study 2Health News:Patients Prefer More Invasive Form of Colon Scan: Study 3Health News:Viral infections in infancy are not associated with wheezing symptoms in later childhood 2Health News:Tiny implanted coil improves lung function in patients with severe emphysema 2Health News:Tiny implanted coil improves lung function in patients with severe emphysema 3Health News:Mayo Clinic urologists present findings at American Urological Association Annual Meeting 2Health News:Mayo Clinic urologists present findings at American Urological Association Annual Meeting 3Health News:Mayo Clinic urologists present findings at American Urological Association Annual Meeting 4
... for local clinics and health technology projectsPORTLAND, Ore., ... eight grants geared toward building healthier communities and ... and Washington. The grants, totaling $380,000, range from ... quality Web site."The Regence Foundation believes philanthropy is ...
... to have a synergistic effect in the development of ... is a genetic disorder, mostly resulting from mutations in ... metabolism which leads to iron accumulation that may eventually ... between iron metabolism, HFE mutations and alcoholic liver disease ...
... is manifested in a variety of tissues and cancer ... currently being studied as a novel treatment. The PPAR-gamma ... via differentiation, apoptotic induction, and changes in genes or ... have been some reports suggesting that stomach cancer cells ...
... BISMARCK, N.D., Feb. 17 Due to the ... across the United States, Bismarck and,surrounding area optometrists ... assessments for infants between six to 12 months,of ... developed,by the American Optometric Association (AOA) in partnership ...
... pressure affects use of sunscreen, coverups, study finds , , TUESDAY, ... likely to follow sun safety measures if their peers do ... in Atlanta. , Lifeguards and aquatic instructors at outdoor ... M. Hall and colleagues at the university,s Rollins School of ...
... the treatment of epilepsy in children, in many cases ... of vision. Serge Picaud, head of research at Inserm, ... have just discovered the origin of this secondary effect ... shown that vigabatrin provokes a marked decrease in the ...
Other Medicine News:Health News:Grants Strengthen the Health Care Safety Net 2Health News:Grants Strengthen the Health Care Safety Net 3Health News:What is the suppressing effect of the PPAR-gamma ligands on stomach cancer cells? 2Health News:ND Optometrists Partner With U.S. Sens. Conrad and Dorgan, Rep. Pomeroy and Gov. Hoeven in Improving Infant Eye and Vision Care 2Health News:ND Optometrists Partner With U.S. Sens. Conrad and Dorgan, Rep. Pomeroy and Gov. Hoeven in Improving Infant Eye and Vision Care 3Health News:ND Optometrists Partner With U.S. Sens. Conrad and Dorgan, Rep. Pomeroy and Gov. Hoeven in Improving Infant Eye and Vision Care 4Health News:ND Optometrists Partner With U.S. Sens. Conrad and Dorgan, Rep. Pomeroy and Gov. Hoeven in Improving Infant Eye and Vision Care 5Health News:ND Optometrists Partner With U.S. Sens. Conrad and Dorgan, Rep. Pomeroy and Gov. Hoeven in Improving Infant Eye and Vision Care 6Health News:On Sun Safety, Pool Staff May Take Cue From Others 2Health News:Taurine: Key to the visual toxicity of an anti-epileptic drug for children? 2Health News:Taurine: Key to the visual toxicity of an anti-epileptic drug for children? 3
(Date:5/22/2012)... Vanda Pharmaceuticals Inc. (NASDAQ: VNDA ), ... commercialization of products for central nervous system disorders, ... at the Society for Research on Biological Rhythms ... The first poster entitled Pleiomorphic Expression of ... insight into the challenges faced by individuals suffering ...
(Date:5/22/2012)... ALLEGAN, Mich., May 22, 2012  Perrigo Company ... final approval from the U.S. Food and Drug ... for butoconazole nitrate 2% vaginal cream, the generic ... submit a substantially complete ANDA with a paragraph ... marketing exclusivity. Perrigo is working exclusively with KV Pharmaceutical ...
(Date:5/22/2012)... Generics, a division of Prodigy Health Supplier Corporation ... generic equivalent of the branded drug Camptosar by ... Laboratories to develop a portfolio of oncology products. ... developed through the partnership that will add consistent ... market, which has experienced record levels of shortages ...
Breaking Medicine Technology:Vanda Pharmaceuticals Inc. Presents Scientific Posters at Society for Research on Biological Rhythms (SRBR) Annual Meeting 2Vanda Pharmaceuticals Inc. Presents Scientific Posters at Society for Research on Biological Rhythms (SRBR) Annual Meeting 3Perrigo Receives FDA Approval for Butoconazole Nitrate 2% Vaginal Cream 2Perrigo Receives FDA Approval for Butoconazole Nitrate 2% Vaginal Cream 3GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine 19815 1GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine 19815 2GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine 19815 3GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine 19815 4ULURU Inc Announces the Engagement of Gilford Securities Incorporated to Serve as the Companys Financial Advisor 18324 1ULURU Inc Announces the Engagement of Gilford Securities Incorporated to Serve as the Companys Financial Advisor 18324 2MAP Pharmaceuticals to Present Data on LEVADEX AE at the 15th Congress of the International Headache Society 18320 1MAP Pharmaceuticals to Present Data on LEVADEX AE at the 15th Congress of the International Headache Society 18320 2MAP Pharmaceuticals to Present Data on LEVADEX AE at the 15th Congress of the International Headache Society 18320 3MAP Pharmaceuticals to Present Data on LEVADEX AE at the 15th Congress of the International Headache Society 18320 4
... and CHAPEL HILL, N.C., US, March 06, ... Orphan") and,Lantibio, Inc. ("Lantibio") today announced positive ... II clinical,study of Moli1901, an experimental compound ... developed by AOP Orphan in,Europe under a ...
... Accentia,Biopharmaceuticals, Inc. (NASDAQ: ABPI), presented three posters at,the ... Asthma, and,Immunology from February 23 - 27, 2007 ... a survey of 202 otolaryngologists,(ENTs) and allergists in ... of chronic sinusitis (CS), the knowledge and attitudes ...
Other Medicine Technology:AOP Orphan Pharmaceuticals and Lantibio Announce Positive Phase II,Study with Novel Cystic Fibrosis Therapy 2AOP Orphan Pharmaceuticals and Lantibio Announce Positive Phase II,Study with Novel Cystic Fibrosis Therapy 3AOP Orphan Pharmaceuticals and Lantibio Announce Positive Phase II,Study with Novel Cystic Fibrosis Therapy 4Accentia Biopharmaceuticals Scientific Presentations Demonstrate,Increasing Acceptance of Fungal Etiology of Chronic Sinusitis at,the Annual Meeting of the American Academy of Allergy, Asthma, and,Immunology 2Accentia Biopharmaceuticals Scientific Presentations Demonstrate,Increasing Acceptance of Fungal Etiology of Chronic Sinusitis at,the Annual Meeting of the American Academy of Allergy, Asthma, and,Immunology 3Accentia Biopharmaceuticals Scientific Presentations Demonstrate,Increasing Acceptance of Fungal Etiology of Chronic Sinusitis at,the Annual Meeting of the American Academy of Allergy, Asthma, and,Immunology 4Accentia Biopharmaceuticals Scientific Presentations Demonstrate,Increasing Acceptance of Fungal Etiology of Chronic Sinusitis at,the Annual Meeting of the American Academy of Allergy, Asthma, and,Immunology 5
... patented polymerase chain reaction (PCR) technology, the ... an essential component of Roches blood screening ... minute amounts of selected unique regions of ... of copies (that is, to detectable levels) ...
... market in New Technology, the Arrow International ... new first and only IABP system that ... physiologically based timing algorithm, WAVE, to deliver ... Second generation Automaticity provides for sophisticated ...
... the worlds first truly automated ... introduced a whole new level ... system modularity and ease of ... The NexES Systems automated technology ...
... is a nonprofit, physician-directed organization promoting ... patient care through programs of voluntary ... laboratory professionals in all sizes of ... laboratory accreditation, quality management services, consultation ...
Medicine Products: