Navigation Links
Tumors hide out from the immune system by mimicking lymph nodes
Date:3/25/2010

A new mechanism explaining how tumors escape the body's natural immune surveillance has recently been discovered at EPFL (Ecole Polytechnique Fdrale de Lausanne) in Switzerland. The study shows how tumors can create a tolerant microenviroment and avoid attack by the immune system by mimicking key features of lymph nodes. The discovery, published in Science and in Science Express, online March 25, 2010, underscores the role of the lymphatic system in cancer and may open up new possibilities for cancer treatment.

"The tumor tricks the body into thinking it is healthy tissue," says lead author Melody Swartz, head of the Laboratory of Lymphatic and Cancer Bioengineering (LLCB) and EPFL professor. Swartz and her team set out to understand how immune tolerance is induced by tumors, allowing them to progress and spread. The researchers from EPFL concentrated their efforts on a certain protein that is normally present in healthy lymph nodes to attract T cells and program them to perform vital immune functions. They found that some tumors can secrete this protein to transform the outer layer of the tumor into lymphoid-like tissue. This outer layer then attracts and effectively re-programs the T cells to recognize the tumor as friend not foe, resulting in a tumor that goes undetected by the immune system.

Since most tumors progress only if they have escaped the immune system, this new understanding of one mechanism by which the tumor can bypasses or hides from immune defenses is an important step towards future cancer therapies. "The finding that tumors can attract nave and regulatory T cells and educate them has important implications for tumor immunotherapy," says Jacqui Shields, from LLCB. The study also opens up potential novel areas of research focusing on the relationship between lymphatic systems and cancer research. According to Shields, the concept that tumors mimic lymphoid tissue to alter the host's immune response represents a new understanding of tumors' interactions with the lymphatic system.


'/>"/>

Contact: Michael Mitchell
michael.mitchell@epfl.ch
41-216-937-022
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert  

Related medicine news :

1. Chemo Plus Synthetic Drug Shrunk Pancreatic Tumors
2. Tumors Use a Protein to Hide From Immune System
3. Radiation May Help Those With Inoperable Lung Tumors
4. SBRT eliminates tumors with promising survival for early-stage inoperable lung cancer patients
5. Freezing Tumors Shows Promise Against Prostate, Breast Cancer
6. MRIs May Detect Hidden Tumors in Breast Cancer Patients
7. Tumors may respond to extreme and moderate heat
8. Scientists Find Key to Hormone-Resistant Prostate Tumors
9. MRI finds tumors in second breast of women diagnosed with cancer in one breast, Mayo researchers say
10. High weight associated with risk of colorectal tumors without microsatellite instability
11. Freezing breast tumors helps stop cancer’s spread in mice, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tumors hide out from the immune system by mimicking lymph nodes
(Date:5/24/2016)... ... ... Controlling and maintaining the home’s water heater just got infinitely easier, more ... Controller , a first-of-its-kind system that enables remote and convenient control of a water ... for HVAC systems, Aquanta gives users a much more efficient, versatile way to use ...
(Date:5/24/2016)... Forest Lake, Minnesota (PRWEB) , ... May 24, ... ... his 13th mission trip to the Dominican Republic on September 21, 2016. Dr. ... Biology from Northwestern, serves with ChiroMission, a not-for-profit organization promoting health and wellness ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... , Out patient Services To Begin In June , Aloria Health, specializing in ... announce the opening of Aloria Milwaukee, its first treatment facility for outpatient, day ...
(Date:5/24/2016)... ... 2016 , ... "ProText Layouts Vol. 3 is a plugin that will keep ... Studios. , ProText Layouts Vol. 3 is a set of 30 self-animating kinetic text ... Layouts, video editors can create an lively typography video with incredible ease. Utilize intuitive ...
(Date:5/24/2016)... ... May 24, 2016 , ... The old expression “a ... problem. A common injury that’s often misunderstood, whiplash should be swiftly diagnosed and treated ... orthopedic spine surgeon at Atlantic Spine Center . , So named because ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... 2016 The global  reprocessed medical ... by 2022, according to a new study by Grand ... coupled with the lack of centralized support for waste ... the demand for reprocessed medical devices market. Additionally, the ... that of the original device is the high impact ...
(Date:5/22/2016)... May 23, 2016 DS ... anti-fibrotic and anti-inflammatory compound DS102 in chronic obstructive ... non-alcoholic steatohepatitis (NASH) patients. Recent DS ... in lung tissue and has bronchodilatory, anti-inflammatory and ... administration. The Company will publish further detail on ...
(Date:5/20/2016)... 20, 2016 The Biotech arena ... that the industry is not far from recovering. There ... featured the following four equities: Anacor Pharmaceuticals Inc. (NASDAQ: ... ATHX ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... ). Sign up for your free trading alerts on ...
Breaking Medicine Technology: