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Tumors grow faster without blood-supply promoting molecule
Date:11/10/2008

ssels disappeared when the inflammatory cells couldn't make VEGF," Johnson said.

But the cancer grew faster.

All of the mice developed tumors, but at 20 weeks of age, those with low levels of VEGF from inflammatory cells had larger growths that were more likely to have progressed to a later stage of cancer.

"The tumors seemed much happier when they didn't have this chaotic vasculature," Johnson said.

The scientists also injected a cancerous cell line into normal and engineered mice and found that the introduced cells invaded normal tissues more readily without VEGF from inflammatory cells and developed more normal blood supplies.

The tumors that formed were also more susceptible to two different chemotherapy drugs in the mice lacking VEGF from inflammatory cells.

By identifying the cellular source of the critical factor for one pathology associated with cancer, the researchers say their findings may open new avenues for treatment.


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Contact: Randall Johnson
rsjohnson@ucsd.edu
858-822-0509
University of California - San Diego
Source:Eurekalert

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