Navigation Links
Tumors deliberately create conditions that inhibit body's best immune response
Date:3/1/2013

nis. In the presence of healthy cells, the body's immune response functions normally, and IgG1 are the main antibodies circulating.

To better understand the functional implications of IgG4 subclass antibodies in cancer, the authors engineered these two antibodies (IgG1, IgG4) against a tumour antigen and demonstrated that unlike IgG1, the IgG4 antibody was ineffective in triggering immune cells to kill cancer cells. Importantly, IgG4 also blocked the tumour cell killing actions of IgG1, thus preventing this antibody from activating immune cells to destroy tumours.

Additionally, using samples from 33 patients, the authors found that patients with higher IgG4 levels in their blood are more likely to have a less favourable prognosis compared to those whose blood levels of IgG4 are closer to normal levels. This suggests that IgG4 may help assist in predicting disease progression.

"This work bears important implications for future therapies since not only are IgG4 antibodies ineffective in activating immune cells to kill tumours but they also work by blocking antibodies from killing tumour cells," says Dr Karagiannis. "The latter means that IgG4 not only prevents the patient's more powerful antibodies from eradicating cancer, but could also explain why treatments may be hindered by those native IgG4 antibodies found in patients, making therapeutic antibodies less effective."

"Now, with the help of our NIHR Biomedical Research Centre, more work needs to be done on developing IgG4 as a potential clinical and prognostic biomarker which can improve patient care by informing clinical decisions and helping to identify patients most likely to respond to treatments," concludes Professor Nestle. Therefore, these findings are expected to inform the design and help improve the potency and efficacy of future therapies for cancer. "This study can also inform the rational design of novel strategies to counteract IgG4 actions."

The authors are now broadening the
'/>"/>

Contact: Marianne Slegers
marianne.slegers@kcl.ac.uk
44-207-848-3840
King's College London
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Dental X-Rays May Be Linked to Benign Brain Tumors
2. New surgical technique for removing inoperable tumors of the abdomen
3. Combination of 2 drugs reverses liver tumors
4. Genetic test identifies eye cancer tumors likely to spread
5. Strategy discovered to activate genes that suppress tumors and inhibit cancer
6. Mount Sinai researchers develop a multi-target approach to treating tumors
7. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
8. Specialized MRI scans assess value of anti-cancer chemotherapy long before tumors shown to shrink
9. Pediatric tumors traced to stem cells in developing brain​​
10. Study shows colon and rectal tumors constitute a single type of cancer
11. Genetic mutations that cause common childhood brain tumors identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... older age with kidney and heart disease have raised ... older adults. However, in the first study to look ... of Medicine at the University of Pennsylvania report that ... life expectancy and cardiovascular health as very healthy older ... of the ever increasing organ transplant waitlists, the authors ...
(Date:7/9/2014)... 2014 A study published in the scientific journal ... Robert Bonin, two researchers at Universit Laval, reveals that ... new method that involves rekindling pain so that it ... novel means to alleviate chronic pain. , The researchers ... Institut universitaire en sant mentale de Qubec (IUSMQ) were ...
(Date:7/9/2014)... from the Keck School of Medicine of the ... mice lacking a specific component of the immune ... fatal complication of infection. The discovery suggests that ... inflammation in human autoimmune and hyper-inflammatory diseases such ... The study was published online on June 23 ...
(Date:7/8/2014)... been awarded up to $15 million by the Defense ... project aiming to help brain-injured people restore lost memory ... neurobiology, psychology and physics will collaborate to create, surgically ... , Memory is the process in which neurons in ... and retrieve it. Certain types of illnesses and injuries ...
(Date:7/8/2014)... from Plymouth, UK, and Sydney, Australia, have today (Wednesday ... ACEmobile - a free-to-use app to support the assessment ... first of its kind; an iPad-based tool that supports ... the whole process, meaning more members of the clinical ... assessment. Designed by clinicians for clinicians, ACEmobile also collects ...
Breaking Medicine News(10 mins):Health News:Penn study finds living kidney donation does not increase risk of death or heart disease for older 2Health News:Discovery of a new means to erase pain 2Health News:DARPA awards UCLA $15 million to restore lost memory 2Health News:DARPA awards UCLA $15 million to restore lost memory 3Health News:New app widens opportunities for dementia assessments 2Health News:New app widens opportunities for dementia assessments 3
... May 1 As this week,s headlines have made it ... it comes to protecting yourself against flu outbreaks. What,s the ... thorough hand washing! According to the Centers for Disease Control ... "wash your hands often with soap and water, especially after ...
... patients lifetime of problems , , FRIDAY, May 1 (HealthDay ... getting a good night,s sleep could be in store ... , The study of 281 children, aged 10 to ... regardless of the severity of that condition, they were ...
... honors journalists for orthopaedic-related coverageROSEMONT, Ill., May 1 ... (AAOS) has announced the winners of its 2009 ... year and honors media efforts that further public understanding ... the care of bones, joints, muscles and tendons. ...
... Takes Place on the Eve of the 8th Annual National ... for 14 straight years, the teen birth rate in the ... in Washington, DC sponsored by The National Campaign to Prevent ... rate is increasing and will explore ways to try to ...
... Research supported by Shaklee Corporation, the number one natural ... blood vitamin D level is associated with metabolic syndrome ... are currently being presented at the National Lipid Association ... important role of vitamin D nutrition for maintaining cardiovascular ...
... Product Offering of Avalign Technologies, Inc.LAKE FOREST, ... ("RoundTable"), an operating-oriented private equity firm focused ... that its portfolio company, Avalign Technologies, ... instruments, implants, and delivery systems to the ...
Cached Medicine News:Health News:Protect Yourself with Hand Washing Help from Bath & Body Works 2Health News:Protect Yourself with Hand Washing Help from Bath & Body Works 3Health News:Treating Sleep Disorders May Ease ADHD Symptoms 2Health News:American Academy of Orthopaedic Surgeons Announces Media Orthopaedic Reporting Excellence (MORE) Award Winners 2Health News:American Academy of Orthopaedic Surgeons Announces Media Orthopaedic Reporting Excellence (MORE) Award Winners 3Health News:Forum Explores Solutions to the Rise in the Teen Birth Rate 2Health News:Forum Explores Solutions to the Rise in the Teen Birth Rate 3Health News:Vitamin D Linked to HDL Cholesterol - Shaklee Corporation Research Links Vitamin D with Key Biomarkers for Metabolic Syndrome and Heart Disease 2Health News:RoundTable Healthcare Partners Completes Portfolio Company Add-On Acquisition 2Health News:RoundTable Healthcare Partners Completes Portfolio Company Add-On Acquisition 3
(Date:1/15/2014)... Jan. 15, 2014 Massachusetts General Hospital (MGH), ... AMGN ) announced today that they have launched ... new therapeutic targets and develop novel therapies for ... affects millions worldwide. The MGH-Broad-Amgen collaboration brings together ...
(Date:1/15/2014)... Fla. , Jan. 15, 2014  In an unprecedented effort to ... TB in ambulances and other transport vehicles, an advanced and portable ... rescue personnel for the first time. In order ... with these deadly pathogens, West Palm Beach ...
(Date:1/15/2014)... TORONTO , Jan. 15, 2014  According to ... medical technology market intelligence, the United ... occlusion (TEO) device markets will expand moderately through ... fastest-growing segments. In particular, increasing interest in drug-eluting ...
Breaking Medicine Technology:Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Superbugs No Longer Ride In Rescue Vehicles 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
... is pleased to announce the signing of a reseller ... CIVCO,s Body Pro-Lok to its customers. Introduced in 2008 ... worldwide, Body Pro-Lok excels as a modular base for ... (Logo: http://photos.prnewswire.com/prnh/20110419/AQ85801LOGO ) ...
... July 29, 2011 Argos Therapeutics, Inc. today announced that ... the U.S. Securities and Exchange Commission (SEC) relating to a ... All shares of the common stock to be sold in ... Lazard Capital Markets LLC and Canaccord Genuity Inc. are acting ...
Cached Medicine Technology:Varian Medical Systems to Offer CIVCO Medical Solutions' Body Pro-Lok™ for SBRT 2Argos Therapeutics Files Registration Statement for Proposed Initial Public Offering 2
Bone Curette, 180 mm...
Kevorkian Collector Endocervical Curette is a stainless-steel curette with rounded tip....
Kevorkian Endocervical Curette is a stainless-steel curette with a basket. It is narrow tipped for sampling without dilation....
...
Medicine Products: