Navigation Links
Tumors Spotted Between Mammograms Often More Aggressive: Study
Date:5/3/2011

By Amanda Gardner
HealthDay Reporter

TUESDAY, May 3 (HealthDay News) -- Breast tumors that are detected in between regular screening mammograms tend to be more aggressive and fast-moving than those found during scheduled screenings, indicating that better screening methods are needed, researchers say.

"We may have to look at other imaging techniques or newer technologies to find these types of cancers," said Anna M. Chiarelli, co-author of a study published online May 3 in the Journal of the National Cancer Institute.

Other studies have come up with similar results but they didn't make a distinction between what these authors call "true" interval cancers, meaning those that weren't detectable by a radiologist on a regular screening mammogram but showed up in retrospect, as opposed to "missed" interval cancers, which did show on the previous mammogram but were missed.

"Interval cancers are a heterogeneous group," said Chiarelli, a senior scientist in prevention and cancer control at Cancer Care Ontario in Toronto, Canada. "We wanted to see the different pathologies [and] prognostic factors."

In this study, an interval cancer was one that was diagnosed within two years after the last negative mammogram.

The authors identified "true" interval cancers and "missed" interval cancers in a group of almost 431,500 Ontario women aged 50 or older who were screened from 1994 through 2002.

They then compared those tumors with a control group of mammography-detected cancers.

Both the true and missed interval cancers were more aggressive than the cancers picked up by screening in that they were a higher stage and grade.

But the true interval cancers had even more worrying characteristics -- they were three times more likely to have a high "mitotic index," which is a measure of how fast the cells are dividing. They were also more than twice as likely to be both estrogen-receptor and progesterone-receptor negative, which means that they cannot be fought with hormonal therapies and so are usually harder to treat.

True interval cancers were also more likely to belong to the minority of breast cancers that do not originate in the milk ducts.

"The true interval cancers were even worse than the missed intervals," Chiarelli said.

It's possible the missed cancers had worse characteristics than the true intervals simply because they were caught later, she added.

One expert said the phenomenon might not be so common in the United States, however.

"In Canada they only do mammograms every two years, so the number of interval cancers in the U.S. is going to be smaller because we're doing mammograms every year," said Dr. Paul Tartter, a senior breast surgeon with St. Luke's-Roosevelt Hospital's Comprehensive Breast Center in New York City. "Also, all of these mammograms were done before digital mammography, so hopefully digital mammography will reduce the number of missed cancers," he said.

Ultrasound detection is one other option that women might have available to them to spot cancers, said Dr. Stephanie Bernik, chief of surgical oncology at Lenox Hill Hospital in New York City. But, she added, "it's hard to prove a large benefit to ultrasound."

Still, when interpreted by the right person, "it's definitely useful in women with dense breast tissue," Bernik added.

But although women with denser breast tissue might benefit from this additional screening, it's often not covered by insurance, she noted.

"The good news is that interval cancers are a small percentage of cancers," Chiarelli said. "Most cancers are found from [mammographic] screening but it's important to look at these and to have to find a technique to detect them."

In contrast to a recent guideline change, Bernik advised that women should start getting mammograms when they're 40 years old.

More information

The U.S. National Cancer Institute has more on breast cancer screening.

SOURCES: Anna M. Chiarelli, Ph.D., senior scientist, prevention and cancer control, Cancer Care Ontario, Toronto, Canada; Paul Tartter, M.D., senior breast surgeon, St. Luke's-Roosevelt Hospital's Comprehensive Breast Center, New York City; Stephanie Bernik, M.D., chief of surgical oncology, Lenox Hill Hospital, New York City; May 3, 2011, Journal of the National Cancer Institute, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Benefit of PET in patients with head and neck tumors cannot be assessed
2. Gynecologic cancer expert helps pinpoint best treatment for fast-growing gestational tumors
3. Molecule Nutlin-3a activates a signal inducing cell death and senescence in primary brain tumors
4. Scientists find potential benefit of hypericin for recurrent brain tumors
5. People With Epilepsy More Prone to Brain Tumors: Study
6. MIT biologists pinpoint a genetic change that helps tumors move to other parts of the body
7. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
8. Most Breast Tumors Have Unique Genetic Fingerprint, Study Finds
9. Annual report to the nation focuses on brain tumors
10. Microchip Spots Cancerous Tumors Within an Hour, Study Shows
11. Protein fuels inflammation in pancreatic and breast tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tumors Spotted Between Mammograms Often More Aggressive: Study
(Date:6/27/2017)... Fla. (PRWEB) , ... June 27, 2017 , ... ... today announced the appointment of Mike Finnegan to the position of Executive Vice ... years of experience in healthcare technology, telehealth and medical device sales leadership. He ...
(Date:6/27/2017)... ... ... The Congressional Budget Office (CBO) projects that the Better Care Reconciliation Act ... Affordable Care Act (ACA), would result in 22 million Americans losing their health insurance ... than 20 million Americans have gained health insurance under the ACA, and from 2013 ...
(Date:6/27/2017)... ... June 27, 2017 , ... ... and personal financial planning services to residents of southern New Hampshire, is teaming ... that promises to fight hunger and homelessness in the region. , New Horizons ...
(Date:6/27/2017)... ... 2017 , ... Hammer Strength, the world’s leading performance strength training brand, and ... Houston Rockets the NBSCA Strength & Conditioning Coach of the Year. , In ... vote to select the coach who embodies the highest level of excellence and outstanding ...
(Date:6/26/2017)... ... June 26, 2017 , ... Torrance dentist, Dr. Robert Mondavi ... of the most noticeable aspects of a person’s appearance. A healthy, radiant smile can ... with beautiful, balanced teeth, everyone can have the smile of their dreams with cosmetic ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... Corp. is voluntarily performing a worldwide field correction of certain Intra-Aortic Balloon Pumps ... ... CS100i IABP ... 0998-UC-0446HXX; 0998-UC-0479HXX 0998-00-3013-XX;  0998-UC-3013-XX 0998-00-3023-XX;  0998-UC-3023-XX ... This field correction also applies to any System 98 or ...
(Date:6/14/2017)... N.C. , June 14, 2017  In 2016, ... Creative Startups pitch competition and came away ... reality platform is described by Forbes as "entering the ... American Medical Association as teaching "empathy to medical professionals ... the startup was recently named a finalist for the ...
(Date:6/10/2017)... , June 9, 2017  Shane K. Burchfield, DPM, is ... for excellence as a Podiatrist in Alabama . ... at Family First Foot Care. He brings over 20 years of ... pain management and healthcare, to his role. ... Foot Care, PC is pleased to welcome you to ...
Breaking Medicine Technology: