Navigation Links
Tumor suppressor genes vital to regulating blood precursor cells in fruit flies
Date:9/5/2012

UCLA stem cell scientists have shown that two common tumor suppressor genes, TSC and PTEN, are vital to regulating the stem cell-like precursor cells that create the blood supply in Drosophila, the common fruit fly.

The researchers examined a signaling pathway called TOR that the cells use to gauge nutrition levels and stress, said study senior author Dr. Julian A. Martinez-Agosto, an assistant professor of human genetics and pediatrics and a researcher with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.

"We wondered how an organism knows how many blood cells to make and when to make them in the context of injury and repair to tissue. In particular, we wondered how the blood progenitor cells sense that change and know when it's time to make more blood cells," Martinez-Agosto said. "We found that the TOR pathway uses these two genes to regulate its function and, when activated, it expands or increases the number of blood progenitor cells in the fly's blood."

The study appears Sept. 5, 2012 in the advance online issue of the peer-reviewed journal Development.

Michelle Dragojlovic-Munther, a graduate student in the Martinez-Agosto laboratory and first author of the study, found that cells with increased activity of TOR have a competitive advantage, allowing them to divide and make more of themselves so they can make blood. These progenitors, Dragojlovic-Munther found, also have high levels of reactive oxygen species (ROS) - ions or very small molecules that include free radicals which are known to damage cells and can predispose humans to aging and heart disease. But in this case, the ROS proved valuable.

The precursors, Martinez-Agosto said, were producing ROS all the time and when TOR was activated, the levels increased dramatically. Too much ROS caused them to divide more than normal. If they treated the flies with antioxidants, which reduce ROS levels, the c
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-425-9457
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Improved Stem Cell Line May Avoid Tumor Risk: Study
2. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
3. Dental X-Rays May Be Linked to Benign Brain Tumors
4. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
5. Brain Tumor Vaccine Shows Promise in Early Trial
6. Kidney Cancer Patients Fare Better With Tumor Removal Only
7. IBN discovers human neural stem cells with tumor targeting ability
8. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
9. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
10. New surgical technique for removing inoperable tumors of the abdomen
11. Combination of 2 drugs reverses liver tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Colorado (PRWEB) July 29, 2014 The ... Gossip reveals the inside story to Gary M. Levin’s ... a remarkable cure method for this serious disorder. Levin ... most discouraging conditions that can be found in patients. ... MD and surgeon. For many years, Levin has worked ...
(Date:7/29/2014)... Winter is here down under, and ... Sydney’s central business district. That is, until a troop ... the otherwise ordinary day into a celebration—a celebration of ... advocates of The Truth About Drugs, a drug prevention ... They woke up the city with a rousing performance ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 Daily Gossip reveals ... 5 step holistic system that will permanently eliminate all the ... Coleman his natural treatment will banish symptoms such as mild ... beeping sound heard by patients will be gone forever. , ... 60 days. The author of this program says that at ...
(Date:7/29/2014)... TUESDAY, July 29, 2014 (HealthDay News) --,The time at ... affect their chances for survival, new research suggests. ... weekends or during holidays is associated with a 13 ... business hours, researchers report. Every year, more than ... most severe type of heart attack, which is caused ...
(Date:7/29/2014)... the bite of a brown recluse spider is poisonous, ... expert notes. It,s still important to recognize the ... recluse spider bite, warned Dr. Donna Seger, medical director ... dangerous bites are on the rise. "As physicians, ... [bite] has classic characteristics, but if physicians are not ...
Breaking Medicine News(10 mins):Health News:Natural Multiple Sclerosis Treatment Review Reveals the Inside Story to Gary M. Levin’s Cure Program 2Health News:Sydney Business District “Rocked” by The Truth About Drugs 2Health News:Tinnitus Miracle Review Exposes the Only Holistic System for Tinnitus Cure 2Health News:Heart Attack Patients Treated at Night, Weekends May Have Worse Outcomes 2Health News:Brown Recluse Spider Bites on the Rise, Expert Warns 2
... Aeras and the China National Biotech Group (CNBG) today ... organizations to pursue opportunities to jointly develop tuberculosis (TB) vaccines ... The partnership is intended to leverage both organizations, capabilities ... a major public health priority in China, where there are ...
... Serena Gordon HealthDay Reporter , MONDAY, July 25 (HealthDay ... worry to add to their list: Kids younger than 10 years ... on their own. New research found that while children ... the street solo -- they do stop and look both ways ...
... specific genes shuts down the mass production of antibodies launched ... by scientists at The University of Texas MD Anderson Cancer ... "Regulatory T cells prevent unwanted or exaggerated immune system ... been unclear," said paper senior author Chen Dong, Ph.D., professor ...
... ALBUQUERQUE, N.M. Americans are used to drinking from ... water utilities might be vulnerable to terrorist attacks or ... an open-source software developed by Sandia National Laboratories ... public water systems can be protected through enhanced detection ...
... , MONDAY, July 25 (HealthDay News) -- As ... school this fall, the American Lung Association urged parents to ... and help ease their transition back to the classroom. ... back-to-school necessities, it is even more essential for parents of ...
... of oncologists in the Program in Women,s Oncology at Women ... guide to the human papilloma virus (HPV) so physicians can ... women with the virus. Dx/Rx: Human Papilloma Virus was ... oncology at Women & Infants and associate professor of obstetrics ...
Cached Medicine News:Health News:Aeras and China National Biotech Group sign memorandum of understanding for TB vaccine R&D 2Health News:Kids With ADHD Less Adept at Crossing the Street: Study 2Health News:Kids With ADHD Less Adept at Crossing the Street: Study 3Health News:Specialized regulatory T cell stifles antibody production centers 2Health News:Specialized regulatory T cell stifles antibody production centers 3Health News:Sandia's CANARY software protects water utilities from terrorist attacks and contaminants 2Health News:Sandia's CANARY software protects water utilities from terrorist attacks and contaminants 3Health News:Preparation Key When Kids With Asthma Go Back to School 2Health News:Oncologists publish HPV manual for physicians 2
(Date:7/29/2014)... ROCKY HILL, Conn. , July 29, 2014 ... 28, 2014, Mike Swinford will be the company,s ... after a highly successful 22-year career at GE where he ... $200 million in annual revenue to over $5 billion. His ... Healthcare Global Services. "I am thrilled to ...
(Date:7/29/2014)... 29, 2014 McGraw-Hill Education Professional, a leading ... technical, and medical communities, has announced the launch of ... application of the world-renowned medical education platform. ... App , available for download onto all iOS and ... to gain access to valuable AccessMedicine diagnostic ...
(Date:7/29/2014)... 2014  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ... second quarter 2014 financial results after the Nasdaq market ... host a live conference call and webcast to discuss ... morning, August 7, 2014 at 8:00 a.m. Eastern Time ... the live conference call by dialing 866-952-1907 (US) or ...
Breaking Medicine Technology:Numotion Names Mike Swinford CEO 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 3Neurocrine Biosciences Announces Conference Call And Webcast To Report Second Quarter 2014 Financial Results 2
... The product is intended for ... spine following anterior fusion. The device ... addition, load sharing is enhanced through ... thickness. Anterior cervical single level interbody ...
... the newest addition to the ... plates. Ant-Cer addresses the unique ... the cervical spine. It enables ... to fit patients' unique needs. ...
... plate system is a family of plates ... provides for consistent, reliable fixation of plate ... or backout. This innovative design eliminates the ... implant your screws and the swivel ring ...
Investigational use spacer with Cantilever Transforminal Lumbar Interbody Fusion and instrumentation. For Investigational use only. 7 mm height....
Medicine Products: