Navigation Links
Tumor suppressor genes speed up and slow down aging in engineered mouse
Date:5/30/2008

ROCHESTER, Minn. -- Mayo Clinic researchers have developed an animal model that can test the function of two prominent tumor suppressor genes, p16 and p19, in the aging process. Scientists knew that both these genes were expressed at increased levels as humans and mice age, but their role in the aging process was not clear. Findings by the Mayo team show that p16 provides gas to accelerate cellular aging, while p19 stops that process.

The findings, to be published May 30 in the online issue of Nature Cell Biology, could help explain the development of some characteristics associated with aging, such as loss of muscle mass and strength or cataracts, and how they might be retarded.

"Scientists interested in aging have developed mice that lack p16 or p19, but these mice were not suitable for studies on aging because they all die of cancer before they even begin to age," says the study's first author, Darren Baker, a laboratory technician at Mayo Clinic and a doctoral candidate. "By crossing these mice with a mouse strain that ages five times faster than normal due to a mutation in the BubR1 gene, we were able to bypass this problem."

While other genes are involved in aging, the researchers firmly established that when too much p16 is produced, tissues start to age. Instead of driving aging, the p19 gene was found to counteract the effects of p16. This was completely unexpected, says Jan van Deursen, Ph.D., a molecular biologist at Mayo Clinic, because tissue culture experiments had predicted that p19 expression promotes aging.

Another important finding of the study is that initiation and progression of aging is caused, at least in part, by the accumulation of senescent or aging cells in tissues and organs. These senescent cells have an abnormal gene expression profile and secrete proteins that damage the surrounding cells, affecting tissue and organ function and aspects of aging.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. St. Jude finds young age may give survival advantage to children with certain brain tumors
2. Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers
3. Weill Cornell team identifies new cancer stem cell driving metastatic tumors
4. RTOG Study Likely Treatment Option for Brain Tumor Patients like Sen. Kennedy
5. Ted Kennedy Has a Brain Tumor
6. A potential route for human tumor gene therapy
7. Determining genetic signature of lung tumors can help guide treatment
8. Study: Patients 75 years and older with brain tumors may benefit from more aggressive treatment
9. Protein predicts Gleevec resistance in gastrointestinal tumors
10. Effect of mutant p53 stability on tumorigenesis and drug design
11. Video: Pediatric Brain Tumor Foundation Gives $6 Million Grant to Duke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/27/2017)... Sept. 27, 2017  Commended for their devotion to personalized ... Ranked as number one in the South Florida Business Journal,s ... Inc. 5000 yearly list, the national specialty pharmacy has found ... Bardisa will soon be honored by SFBJ as the ... Set to receive his award in October, Bardisa ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
Breaking Medicine Technology: