Navigation Links
Tumor suppressor genes speed up and slow down aging in engineered mouse
Date:5/30/2008

ROCHESTER, Minn. -- Mayo Clinic researchers have developed an animal model that can test the function of two prominent tumor suppressor genes, p16 and p19, in the aging process. Scientists knew that both these genes were expressed at increased levels as humans and mice age, but their role in the aging process was not clear. Findings by the Mayo team show that p16 provides gas to accelerate cellular aging, while p19 stops that process.

The findings, to be published May 30 in the online issue of Nature Cell Biology, could help explain the development of some characteristics associated with aging, such as loss of muscle mass and strength or cataracts, and how they might be retarded.

"Scientists interested in aging have developed mice that lack p16 or p19, but these mice were not suitable for studies on aging because they all die of cancer before they even begin to age," says the study's first author, Darren Baker, a laboratory technician at Mayo Clinic and a doctoral candidate. "By crossing these mice with a mouse strain that ages five times faster than normal due to a mutation in the BubR1 gene, we were able to bypass this problem."

While other genes are involved in aging, the researchers firmly established that when too much p16 is produced, tissues start to age. Instead of driving aging, the p19 gene was found to counteract the effects of p16. This was completely unexpected, says Jan van Deursen, Ph.D., a molecular biologist at Mayo Clinic, because tissue culture experiments had predicted that p19 expression promotes aging.

Another important finding of the study is that initiation and progression of aging is caused, at least in part, by the accumulation of senescent or aging cells in tissues and organs. These senescent cells have an abnormal gene expression profile and secrete proteins that damage the surrounding cells, affecting tissue and organ function and aspects of aging.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. St. Jude finds young age may give survival advantage to children with certain brain tumors
2. Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers
3. Weill Cornell team identifies new cancer stem cell driving metastatic tumors
4. RTOG Study Likely Treatment Option for Brain Tumor Patients like Sen. Kennedy
5. Ted Kennedy Has a Brain Tumor
6. A potential route for human tumor gene therapy
7. Determining genetic signature of lung tumors can help guide treatment
8. Study: Patients 75 years and older with brain tumors may benefit from more aggressive treatment
9. Protein predicts Gleevec resistance in gastrointestinal tumors
10. Effect of mutant p53 stability on tumorigenesis and drug design
11. Video: Pediatric Brain Tumor Foundation Gives $6 Million Grant to Duke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/17/2019)... RICHMOND, Ky. (PRWEB) , ... July 17, 2019 ... ... was awarded to Eastern Kentucky University’s online Family Nurse Practitioner program. The honor ... for quality in distance education. , The Catalyst Awards honor institutions from ...
(Date:7/17/2019)... , ... July 17, 2019 , ... ... and administrators of critical access hospitals. , The men and women included on ... overseen hospital expansions, mergers and EHR implementations as well as the construction of ...
(Date:7/17/2019)... ... 17, 2019 , ... ICD10monitor, an online news and information ... launching an exclusive educational webcast subscription service featuring 40 original webcast topics and ... week. , The ICD10monitor webcast portfolio already includes sought-after topics such as ...
(Date:7/17/2019)... ... July 17, 2019 , ... This past Saturday, Monarch Dental® hosted ... . Over 50 underserved patients were welcomed at the Mesquite office to receive free ... summer season. Individuals were referred to the event through local nonprofit organizations such as ...
(Date:7/17/2019)... , ... July 17, 2019 , ... A new study ... Journal of the American Medical Association (JAMA), shows for the first time that ... in the state. Sepsis is the body’s extreme response to infection. It kills more ...
Breaking Medicine News(10 mins):
(Date:7/19/2019)... Pa. (PRWEB) , ... July 19, 2019 , ... ... AGILE ), a GLC company, has named Jorge Bacigalupo Director of Education Strategy. ... practice, which currently includes education delivered on six continents and in ten languages. ...
(Date:7/18/2019)... (PRWEB) , ... July 18, 2019 , ... Fresh blueberries ... Bushel and Berry Collection of homegrown edible berry bushes. , These ornamental berry ... healthy, delicious fruit to any garden or on the patio in containers, not out ...
(Date:7/17/2019)... ... July 17, 2019 , ... Highmark Health, Allegheny Health ... enthusiasts from around the region to announce plans for what will be one of ... in Coraopolis on State Avenue and adjacent to the Montour Trail, the complex is ...
Breaking Medicine Technology: