Navigation Links
Tumor mechanism identified
Date:2/22/2010

Researchers from the Peninsula Medical School in Plymouth (UK), the Memorial Sloan-Kettering Cancer Center in New York, Cornell University in New York, Weil Medical College in New York and the Center for Neural Tumour Research in Los Angeles, have for the first time identified a key mechanism that makes certain cells become tumorous in the brain. The resulting tumours occur most often spontaneously but can also occur in numbers as part of the inherited disease Neurofibromatosis type 2.

The research is published in the highly respected journal, Cell.

The tumours are caused by mutations affecting a protein called Merlin, which in turn causes cancers in a range of cell types including Schwann cells. Schwann cells produce the sheaths that surround and insulate neurons.

The new research investigates for the first time the role of Merlin in the cell nucleus. It explains how Merlin regulates cell proliferation, and how it regulates gene expression. Normally Merlin inhibits the development of tumours at a cell nucleus level mutations affecting Merlin affect its ability to inhibit. By understanding this mechanism for the first time, the way is open for the development of effective therapies for a condition in which no treatment other than surgery exists.

In neurofibromatosis 2 the sheer number of the tumours can overwhelm a patient, often leading to severe disability and eventually death. Patients can suffer from 20 to 30 tumours at any one time, and the condition typically affects older children and young adults.

No therapy, other than invasive (radio)surgery aiming at a single tumour and which may not eradicate the full extent of the tumours, exists.

The condition of multiple tumours , neurofibromatosis type two (NF2), affects one in every 2,500 people worldwide. It can affect any family, regardless of past history, through gene mutation and currently there is no cure.

Professor Oliver Hanemann, wh
'/>"/>

Contact: Andrew Gould
andrew.gould@pms.ac.uk
44-139-268-6107
The Peninsula College of Medicine and Dentistry
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
2. Personalizing cancer: Creating biomarkers from tumor DNA
3. Researchers discover second protective role for tumor-suppressor
4. Drug for advanced kidney cancer shrinks tumors prior to surgery
5. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
6. Fluorescent probes light up cancerous tumors
7. Researchers create drug to keep tumor growth switched off
8. Researchers discover new way to kill pediatric brain tumors
9. New Scan May Help Find Aggressive Prostate Tumors
10. CSHL study identifies potential way to reverse cancer cell metabolism and tumor growth
11. American Brain Tumor Association names Alexander Ksendzovsky outstanding 2009 medical student
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... 21, 2013 Parker Waichman LLP, a ... victims injured by defective medical devices, is addressing new ... Surgery on May 15, 2013. The study found that ... complications that occur in patients with metal-on-metal hip implants ... http://www.jbjs.org/article.aspx?articleid=1684770 ) , “We’ve known for ...
(Date:5/21/2013)... CA (PRWEB) May 21, 2013 ... Annual EB-5 Investment Summit: Dealmakers Conference in Long ... Conference will focus on exploring alternative finance through ... the latest market, legal and economic information, and ... and legal professionals within the EB-5 industry. ...
(Date:5/21/2013)... AZ (PRWEB) May 21, 2013 ... and inventors who want to develop their ideas ... summer program. , The university is recruiting ... revolutionary new “formation space” that provides early-stage entrepreneurs ... While AREA48 is open to anyone, ASU is ...
(Date:5/21/2013)... 2013 The In View series ... and cable channels across the country, announces it has ... channel. The producers of the series proudly bring audiences ... industry, the manufacturing industry, health-related companies, medical facilities and ... medical practitioners in all parts of the United States, ...
(Date:5/21/2013)... May 21, 2013 Global Proving Ground ... Bodybuilding.com, the largest online retailer of health and fitness ... reality-based sports show, Warrior Island. “We cast the ... Facebook & Twitter, with our unique social networking platform,” ... these elite fighters on an island in the Pacific ...
Breaking Medicine News(10 mins):Health News:Parker Waichman LLP Comments on New Study Showing that MRI is Useful for Predicting Failure of Metal-on-Metal Hip Implants 2Health News:Parker Waichman LLP Comments on New Study Showing that MRI is Useful for Predicting Failure of Metal-on-Metal Hip Implants 3Health News:Artisan Business Group to Host EB-5 Investment Conference in Long Beach, California 2Health News:ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors 2Health News:ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors 3Health News:ASU Launches Summer Program for Aspiring Entrepreneurs, Innovators and Inventors 4Health News:In View hosted by Larry King Announces New Videos on its YouTube Channel 2Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 2Health News:Bodybuilding.com Partners with Global Proving Ground’s New Reality Show Warrior Island 3
... ... all things eco-licious in style, mama, home, news, and food. Greenista.com,s daily emails to their ... ... Greenista ? A Greenista is a fashionista with a green conscience. Just in time for ...
... ... ... Tahitian Noni International (TNI) announced that XanGo’s parent company DBC, LLC, asked that YouTube ... video portrays multiple superfruit juices trying to attack the stable iridoids of Tahitian ...
... ... EcoBold announces its boldest move to help the green movement. ... ... is taking matters into their own hands. If they can get 1 ...
... ... Plastic Surgery Studios and Candace Crowe Design has grown into a full-fledged partnership. Through ... patient education through multimedia avenues. , ... (PRWEB) April 22, 2010 -- Plastic Surgery Studios, a total ...
... ... voluntary fee-based program tests green product performance on real-world soils. , ... Lowell, MA (PRWEB) April 22, 2010 ... the University of Massachusetts Lowell (UMass Lowell) TURI Lab as a High Performance Cleaning ...
... ... the 11th Best in the United States, , ... Pueblo of Santa Ana (PRWEB) April 22, 2010 -- Tamaya Mist Spa & Salon at the ... in the country by Condé Nast Traveler, one of the nation,s leading travel magazines. The ...
Cached Medicine News:Health News:New Eco Site, Greenista.com, Launches on Earth Day 2Health News:Whimsical Tahitian Noni International YouTube Video Yanked after Competitor Complains 2Health News:EcoBold To Plant One Million Trees 2Health News:Plastic Surgery Studios and Candace Crowe Design Create New Partnership 2Health News:IEHA and UMass Lowell Recognize Activeion as a High Performance Cleaning Product 2Health News:IEHA and UMass Lowell Recognize Activeion as a High Performance Cleaning Product 3Health News:Leading New Mexico Resort Spa At Hyatt Regency Tamaya Ranked Among The Country's Best By Conde Nast Traveler 2Health News:Leading New Mexico Resort Spa At Hyatt Regency Tamaya Ranked Among The Country's Best By Conde Nast Traveler 3
(Date:5/21/2013)... 21, 2013  NxStage Medical, Inc. (Nasdaq: ... today announced that it has entered into new agreements ... products to DaVita, the kidney care division of DaVita Healthcare ... For the use of products for home ... NxStage has executed a second amended and restated National ...
(Date:5/21/2013)... , May 21, 2013 /PRNewswire/ ... VRX ) (TSX: VRX) ... directors nominated at its 2013 annual ... results of the vote for the ... below:  NameForWithheldRonald H. Farmer235,731,9341,964,748Robert A. Ingram233,865,8763,830,806Theo ...
(Date:5/21/2013)... Massachusetts , 21. Mai 2013 /PRNewswire/ ... („OSI"), die die Firmen OMNIlife science® Inc., Enztec ... zählt, hat zwei neue, erfahrene Mitglieder in ... , eine erfahrene Führungspersönlichkeit aus der ... David Johnson , anerkannter ...
Breaking Medicine Technology:NxStage Announces New Agreements with DaVita 2Valeant Pharmaceuticals Announces 2013 Annual Meeting Results 2Orthopaedic Synergy Inc. meldet bedeutenden Zuwachs im Vorstand 2Orthopaedic Synergy Inc. meldet bedeutenden Zuwachs im Vorstand 3
... 2011 OrbusNeich today announced that 12-month follow-up data from ... ccelerated L ining I nhibits N eointimal ... EuroIntervention demonstrated good clinical outcomes with ... the company,s Genous Stent. Target vessel failure (TVF), ...
... school hockey coach is taking the pro-active approach to ... coaches at Stevenson High School, invented the Shockwave ... risk of sustaining a concussion, including athletes, firefighters and ... is a three-step system, starting with baseline testing to ...
Cached Medicine Technology:Published Data From e-HEALING Registry Demonstrate Good Clinical Outcomes With Low Incidence of Repeat Revascularization and Stent Thrombosis for OrbusNeich's Genous™ Stent 2Published Data From e-HEALING Registry Demonstrate Good Clinical Outcomes With Low Incidence of Repeat Revascularization and Stent Thrombosis for OrbusNeich's Genous™ Stent 3Shockwave System Developed to Aid Concussion Detection 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: