Navigation Links
Tumor mechanism identified
Date:2/22/2010

Researchers from the Peninsula Medical School in Plymouth (UK), the Memorial Sloan-Kettering Cancer Center in New York, Cornell University in New York, Weil Medical College in New York and the Center for Neural Tumour Research in Los Angeles, have for the first time identified a key mechanism that makes certain cells become tumorous in the brain. The resulting tumours occur most often spontaneously but can also occur in numbers as part of the inherited disease Neurofibromatosis type 2.

The research is published in the highly respected journal, Cell.

The tumours are caused by mutations affecting a protein called Merlin, which in turn causes cancers in a range of cell types including Schwann cells. Schwann cells produce the sheaths that surround and insulate neurons.

The new research investigates for the first time the role of Merlin in the cell nucleus. It explains how Merlin regulates cell proliferation, and how it regulates gene expression. Normally Merlin inhibits the development of tumours at a cell nucleus level mutations affecting Merlin affect its ability to inhibit. By understanding this mechanism for the first time, the way is open for the development of effective therapies for a condition in which no treatment other than surgery exists.

In neurofibromatosis 2 the sheer number of the tumours can overwhelm a patient, often leading to severe disability and eventually death. Patients can suffer from 20 to 30 tumours at any one time, and the condition typically affects older children and young adults.

No therapy, other than invasive (radio)surgery aiming at a single tumour and which may not eradicate the full extent of the tumours, exists.

The condition of multiple tumours , neurofibromatosis type two (NF2), affects one in every 2,500 people worldwide. It can affect any family, regardless of past history, through gene mutation and currently there is no cure.

Professor Oliver Hanemann, who led the research from the Peninsula Medical School, commented: "This has been an exciting collaboration with colleagues in the United States resulting in a landmark publication. Until now, there has been no meaningful work on the role of Merlin in the nucleus. The results of our research show a greater understanding of the fundamental part played by Merlin in the repression of tumorous cells, and how this part is undermined when the protein is mutated. Identification of the difference in mechanisms will allow us to develop therapies for the future."


'/>"/>

Contact: Andrew Gould
andrew.gould@pms.ac.uk
44-139-268-6107
The Peninsula College of Medicine and Dentistry
Source:Eurekalert

Related medicine news :

1. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
2. Personalizing cancer: Creating biomarkers from tumor DNA
3. Researchers discover second protective role for tumor-suppressor
4. Drug for advanced kidney cancer shrinks tumors prior to surgery
5. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
6. Fluorescent probes light up cancerous tumors
7. Researchers create drug to keep tumor growth switched off
8. Researchers discover new way to kill pediatric brain tumors
9. New Scan May Help Find Aggressive Prostate Tumors
10. CSHL study identifies potential way to reverse cancer cell metabolism and tumor growth
11. American Brain Tumor Association names Alexander Ksendzovsky outstanding 2009 medical student
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released a ... books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture of ... have tossed it off as mere rubbish, but Yisrayl Hawkins says that is because ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the ... “America On The Brink” is the creation of published author, William Nowers. Captain ... As a WWII veteran, he spent thirty years in the Navy. Following his ...
(Date:10/12/2017)... Wis. (PRWEB) , ... October 12, 2017 , ... ... standard products to meet the demand of today’s consumer and regulatory authorities worldwide. ... of probiotic experts and tested to meet the highest standard. , These ...
(Date:10/12/2017)... Maryland (PRWEB) , ... October 12, 2017 , ... ... magnetic drug delivery system that we intend to develop to enable prevention of ... can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & Wellness ... Moonlight to raise money for the American Heart Association Heart Walk. Teams of up ... work together to keep their treadmills moving for 5 hours. Treadmills will start at ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today announced that it will release third-quarter 2017 ... 26, 2017, and will follow with a conference call ... a.m. Eastern Time. To participate on the call, please ... is 94093362. A ...
(Date:10/10/2017)... 2017  NDS received FDA 510(k) clearance in May 2017 for ... stand specifically designed for endoscopy environments. An innovative secondary monitor solution, ... solution to support the improvement of patient outcomes, procedural efficiency, and ... ... ...
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
Breaking Medicine Technology: