Navigation Links
Tumor mechanism identified
Date:2/22/2010

Researchers from the Peninsula Medical School in Plymouth (UK), the Memorial Sloan-Kettering Cancer Center in New York, Cornell University in New York, Weil Medical College in New York and the Center for Neural Tumour Research in Los Angeles, have for the first time identified a key mechanism that makes certain cells become tumorous in the brain. The resulting tumours occur most often spontaneously but can also occur in numbers as part of the inherited disease Neurofibromatosis type 2.

The research is published in the highly respected journal, Cell.

The tumours are caused by mutations affecting a protein called Merlin, which in turn causes cancers in a range of cell types including Schwann cells. Schwann cells produce the sheaths that surround and insulate neurons.

The new research investigates for the first time the role of Merlin in the cell nucleus. It explains how Merlin regulates cell proliferation, and how it regulates gene expression. Normally Merlin inhibits the development of tumours at a cell nucleus level mutations affecting Merlin affect its ability to inhibit. By understanding this mechanism for the first time, the way is open for the development of effective therapies for a condition in which no treatment other than surgery exists.

In neurofibromatosis 2 the sheer number of the tumours can overwhelm a patient, often leading to severe disability and eventually death. Patients can suffer from 20 to 30 tumours at any one time, and the condition typically affects older children and young adults.

No therapy, other than invasive (radio)surgery aiming at a single tumour and which may not eradicate the full extent of the tumours, exists.

The condition of multiple tumours , neurofibromatosis type two (NF2), affects one in every 2,500 people worldwide. It can affect any family, regardless of past history, through gene mutation and currently there is no cure.

Professor Oliver Hanemann, wh
'/>"/>

Contact: Andrew Gould
andrew.gould@pms.ac.uk
44-139-268-6107
The Peninsula College of Medicine and Dentistry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
2. Personalizing cancer: Creating biomarkers from tumor DNA
3. Researchers discover second protective role for tumor-suppressor
4. Drug for advanced kidney cancer shrinks tumors prior to surgery
5. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
6. Fluorescent probes light up cancerous tumors
7. Researchers create drug to keep tumor growth switched off
8. Researchers discover new way to kill pediatric brain tumors
9. New Scan May Help Find Aggressive Prostate Tumors
10. CSHL study identifies potential way to reverse cancer cell metabolism and tumor growth
11. American Brain Tumor Association names Alexander Ksendzovsky outstanding 2009 medical student
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... psychologists have made a brain-related discovery that could ... , This discovery opens up the possibility that ... a specific brain activity that the researchers have ... Journal of Neuroscience has just published ... an associate professor of psychology and his doctoral ...
(Date:4/17/2014)... chronic inflammation in non-cancerous prostate tissue may have nearly ... those with no inflammation, according to results of a ... Kimmel Cancer Center. , The link between persistent inflammation ... high-grade prostate cancer those with a Gleason score ... the most aggressive and rapidly growing prostate cancers. , ...
(Date:4/17/2014)... Experimental Biology and Medicine a multidisciplinary research ... Kenis in the Institute of Genomic Biology (IGB) ... Urbana-Champaign describe their recent work on subcellular redox ... cell functions including energy metabolism, signaling, and transcriptional ... normal cellular behavior, redox status has been recognized ...
(Date:4/17/2014)... has created a new technology for modifying human ... the body and selectively target cancer and other ... that monitor and modify human physiology is a ... existing technology enabled bioengineers to build such devices ... in a customized fashion. , "The project addressed ...
(Date:4/17/2014)... April 17, 2014-- Colic affects about one in five ... numerous pediatric visits during the first several months after ... symptoms was showing promise; however, the April 1, 2014 ... Sung, Valerie) reported on a study, "Probiotics and Infant ... L reuteri for infant colic did not ...
Breaking Medicine News(10 mins):Health News:Scientists discover brain's anti-distraction system 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Building 'smart' cell-based therapies 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
... several commonly-prescribed dementia drugs may be putting elderly Canadians ... , Cholinesterase inhibitors (Aricept, Exelon and Reminyl) are often ... because they increase the level of a chemical in ... drugs are known to provoke slower heart rates and ...
... Public Welfare Estelle B. Richman today responded to critics ... save taxpayers $146 million annually while preserving consumer benefits ... from the Smart Pharmacy initiative are real, not speculative," ... is facing a budget shortfall now and the savings ...
... pain condition common in people with migraines also ... headache, according to a study conducted by researchers ... for Neuroscience. , Approximately half of a group ... a condition that causes patients to have pain ...
... 27 UNICEF has appealed for an additional ... fighting in northwest Pakistan. Over half of the displaced are ... of supplies and funding. , , Humanitarian ... the number of people fleeing fighting that has taken place ...
... of Tennessee and Daiichi Sankyo ATLANTA, ... headquartered in Atlanta, has recently been awarded business ... BlueShield of Tennessee and Daiichi Sankyo, Inc.Studiocom,s healthcare ... these new clients meeting the challenges of the ...
... DIEGO, May 27 ResMed Inc. (NYSE: RMD ... upcoming conferences. David Pendarvis, SVP Organization Development and General Counsel ... the Four Seasons in Chicago on June 10, 2009 at ... CEO will present at the Jefferies Third Annual Healthcare Conference ...
Cached Medicine News:Health News:Dementia drugs may put some patients at risk, Queen's study shows 2Health News:Secretary of Public Welfare Corrects the Record on 'Smart Pharmacy' Initiative 2Health News:UNICEF Appeals for Funding to Urgently Assist Displaced Children and Women in Northwest Pakistan 2Health News:Studiocom Continues Growth with Healthcare Industry Wins 2Health News:Studiocom Continues Growth with Healthcare Industry Wins 3
(Date:1/15/2014)... 15, 2014 Most osteoporosis patients want a choice ... online survey* sponsored by Mission Pharmacal Company. The survey, ... Foundation online support community, revealed that 74 percent of ... in a form other than a pill or a ...
(Date:1/15/2014)... Texas , Jan. 15, 2014  Novation, the leading ... awarded several new IT value-added reseller (VAR) national contracts ... IT goods and services at lower costs. These include ... services such as initiative assistance and ongoing IT consulting ...
(Date:1/15/2014)... Texas , Jan. 15, 2014  Humberto C. Antunes,  ... Achievement Award" from the Journal of Drugs in ... & Clinical Conference (ODAC). The event is January 17-20, 2014, at ... Florida . The ODAC is ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4
... , BURLINGTON, Mass., Oct. 16 Palomar Medical ... researcher and developer of light-based systems for cosmetic ... with Johnson & Johnson Consumer Companies Inc ("JJCC"), ... test and commercialize home-use, light-based devices for (i) ...
... 16 Reportlinker.com announces that a new market ... Reportlinker Adds Pharma 101: An Overview ... , http://www.reportlinker.com/p0155107/Reportlinker-Adds-Pharma-101-An-Overview-of-the-Life-Sciences-Industry-(Analyst-Insight).html , Introduction , ... Without having the proper background, it can be ...
Cached Medicine Technology:Palomar to Commercialize FDA Cleared Over-The-Counter Home Use Wrinkle Treatment Laser Device Without Johnson & Johnson 2Palomar to Commercialize FDA Cleared Over-The-Counter Home Use Wrinkle Treatment Laser Device Without Johnson & Johnson 3Palomar to Commercialize FDA Cleared Over-The-Counter Home Use Wrinkle Treatment Laser Device Without Johnson & Johnson 4Palomar to Commercialize FDA Cleared Over-The-Counter Home Use Wrinkle Treatment Laser Device Without Johnson & Johnson 5Reportlinker Adds Pharma 101: An Overview of the Life Sciences Industry (Analyst Insight) 2
... SuperAnchors are titanium alloy implants ... to bone. They are indicated ... required. The SuperAnchor uses four ... while maintaining small size. The ...
The Mini-Revo suture anchor is designed primarily for arthroscopic and open Bankart shoulder repair. Additional applications include other shoulder repair procedures, as well as use in small joints....
... protection' -- providing complete protection from initial ... with side branches. , ,Proxis is ... not require the attachment or exchange of ... ,Proxis is compatible with all standard ...
... electrophysiology system on the market today, the ... patented "C inside a C" design offering ... ultimate in patient access and flexibility. Usable ... minimizes equipment footprint and can be parked ...
Medicine Products: