Navigation Links
Tumor-killing virus selectively targets diseased brain cells
Date:2/19/2008

WASHINGTON, DC February 19, 2008 New findings show that a specialized virus with the ability to reproduce its tumor-killing genes can selectively target tumors in the brains of mice and eliminate them. Healthy brain tissue remained virtually untouched, according to a Feb. 20 report in The Journal of Neuroscience. With more research, the technique could one day offer a novel way of treating brain cancer in humans.

Most importantly, this study finds that the virus can penetrate into the brain, where it even reaches cells that have migrated away from the main tumor, says Harald Sontheimer, PhD, of the University of Alabama at Birmingham, who was not affiliated with the study. Assuming that the virus behaves similarly in humans, in the future, it may provide a novel and highly efficacious way to treat resistant tumors.

The study is the culmination of six years of basic research into the fundamental processes of viruses and the cells they target, conducted by senior author Anthony van den Pol, PhD, and his team at Yale University School of Medicine. They set out to test the vesicular stomatis virus, which was selected for its ability to attack brain tumors and leave healthy tissue largely uninfected.

Tumor cells from brain cancers commonly found both in people and in mice were implanted into immune-compromised mice, which then received an injection of the virus in the tail. By viewing fluorescent proteins embedded in both tumor and virus cells in the brains of living mice, van den Pols team watched as the virus infected multiple sites in the brain, spreading across an entire tumor within three days, killing tumor cells in its wake. The virus did not target normal mouse tissue or non-cancerous human brain cells transplanted into the mouse brain, the team found. They speculated that, unlike those in healthy brain tissue, blood vessels within brain tumors may leak, allowing the virus to cross the usually impenetrable protective barrier around the brain.

The virus was equally effective in destroying tissue from cancers that start in the breast or lung and spread to the brainthe two cancers most likely to metastasize to the brainand targeted tumors at different sites throughout the body. Each year in the United States, more than 20,000 new cases of brain or nervous system cancers are diagnosed, according to the National Cancer Institute.

Future research will focus on understanding potential safety risks, such as whether the virus could eventually infect normal brain cells, as well exploring potential changes to the virus that could mitigate such risk. We have some ideas for making the virus safer in the human brain, says van den Pol. This is important to prevent the virus from potentially infecting normal brain cells after it has targeted the brain tumor.


'/>"/>

Contact: Sara Harris
sharris@sfn.org
202-963-4000
Society for Neuroscience
Source:Eurekalert

Related medicine news :

1. Virus Could Help Drive Obesity
2. Scientists detect presence of marburg virus in african fruit bats
3. Norwalk virus: Cruise ship illness challenging and costly to hospitals, too
4. Human Papilloma Virus vaccines may decrease chances of oral cancer
5. New viruses to treat bacterial diseases -- My enemies enemy is my friend
6. FDA Approves New Roche West Nile Virus Blood Screening Test
7. Laser blasts viruses in blood
8. Burgeoning Population of Hepatitis C Virus Patients in Need of Second- and Third-Line Treatment Options
9. Novel virus detection identifies new viruses in study of respiratory infections and asthma attacks
10. Customized virus kills brain tumor stem cells that drive lethal cancer
11. Stomach Virus a Culprit in Chronic Fatigue Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 2016 , ... There are many ways to cook a hot dog, but ... Americans prefer their dogs straight off the grill. Of the 90 percent of Americans ... to cook a hot dog, far outpacing other cooking methods such as steaming (12 ...
(Date:5/26/2016)... ... May 26, 2016 , ... Intalere, ... members and suppliers for its inaugural Member Conference at the Paris Hotel in ... elevating the operational health of America’s healthcare providers. , The conference was highlighted ...
(Date:5/26/2016)... ... 26, 2016 , ... On Memorial Day, Hope For Heroes and ... military battle for the country. The nonprofit Hope For Heroes partnered with the ... empower independence for disabled military veterans, as well as police, firemen, and EMS professionals ...
(Date:5/26/2016)... ... 2016 , ... There are nearly 14.5 million people living with and beyond ... Sunday, June 5, 2016, communities around the world will gather to recognize these cancer ... Cancer Survivors Day® is an annual worldwide Celebration of Life that is held on ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. James Maisel will ... Long Island Chapter on June 4, 2016, 1:30-3:30 pm at the Farmingdale Public ... Retina Group of New York , is a Board Certified ophthalmologist who ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 25,2016 FDA 510(k) clearance ... platform for urological and surgical applications ... of Cellvizio®, the multidisciplinary confocal laser endomicroscopy (CLE) ... the US with the 12 th 510(k) ... (FDA). This new FDA clearance covers Confocal Miniprobes ...
(Date:5/25/2016)... May 25, 2016  Zymo Research Corp. announced ... new reference materials that help researchers obtain the ... to analyses. The rapid growth of the study ... to have standard methods to improve the reproducibility ... inherently exist at every step of the measurement ...
(Date:5/25/2016)... , May 25, 2016  Granger Diagnostics today announced ... for wounds and infections. This test ensures discovery ... select viruses. The test requires only a simple swab ... David G. Bostwick , MD, Chief ... facilitate wound healing: "We are excited to make ...
Breaking Medicine Technology: