Navigation Links
Tumor budding identified as predictor for unfavorable outcome in lung cancer
Date:8/31/2010

Lung cancer is the leading cause of cancer deaths worldwide, and the prognosis is generally poor, even if surgery is successful. Furthermore, the incidence of one type of lung cancer, adenocarcinoma, has been increasing in recent years. A better understanding of the changes in tumor cell biology that result in a more aggressive neoplastic phenotype (characteristic of an abnormal mass of tissue) that have been completely surgically removed may help identify patients at risk for recurrent disease and lead to the development of more effective therapeutic treatments. Tumor budding is one such characteristic that may provide insights on advancing the understanding of recurrence.

The term tumor budding refers to single cells or small clusters of up to four cells within the stromal tissue at the invasive margin of colorectal cancers. This morphologic feature is increasingly being recognized as an adverse prognostic factor. To progress in this understanding, a study featured in the September edition of the Journal of Thoracic Oncology (JTO) conducted the first study to evaluate tumor budding in adenocarcinoma of the lung.

In order to investigate the relationship between tumor budding and the prognostic significance, researchers reviewed the cases of 201 consecutive patients who had undergone complete resection of adenocarcinoma of the lung measuring ≤ 30 mm( 1.25 inches) in diameter. The presence of tumor budding was significantly associated with lymph node metastasis, pathologic stage, vascular invasion, lymphatic invasion, and pleural invasion. Furthermore, the overall five-year survival rates of the group with budding and the group without budding was 67.5 and 88.3 percent, respectively, and the difference was significant.

"Overall, the pilot study identified that tumor budding is a distinct morphologic feature that has biologic and prognostic significance; moreover, the presence was identified as a significant predictor of
'/>"/>

Contact: Colleen Butz
cbutz@spectrumscience.com
202-587-2557
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Journal of Vascular and Interventional Radiology sees growth, promise of tumor ablation
2. With muscle-building treatment, mice live longer even as tumors grow
3. Lung stem cells vital to lung repair associated with poor cancer prognosis when found in tumor
4. A lethal brain tumors strength may be a weakness as well
5. Merlin protein found to control liver stem cells, prevent tumor development
6. New drug reduces tumor size in women with advanced hereditary ovarian or breast cancer
7. NIH award will enable design of brain tumor treatment that captures migrating cancer cells
8. New diagnostic chip able to generate single-cell molecular fingerprints for brain tumors
9. Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
10. LA Tumor Registry at LSUHSC awarded $12 million SEER contract by NCI
11. Key pathway in end-stage prostate cancer tumor progression blocked
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... (PRWEB) September 02, 2014 MyRounding, the ... care, has been selected from a group of over ... the 2014 PrIME Digital Health Challenge. The competition will ... another, Tuesday, Sept. 9th at the CSU Denver Atrium ... MyRounding is based in Denver, Colo. The cloud-based, SaaS ...
(Date:9/2/2014)... BESLER Consulting, a leading provider of Medicare ... to announce that it has released a special report ... 2015 Hospital Inpatient Prospective Payment System (IPPS) final rule ... Services. , “Hospitals are facing decreased Medicare reimbursements in ... BESLER’s President and Chief Executive Officer. “We are happy ...
(Date:9/2/2014)... September 02, 2014 “Is there an ... question that millions of people ask. Diagnosing and curing ... patients and their families or treatment partners. The diagnostic ... its distinct similarities to other skin conditions such as: ... bites, eczema, varicella and many others. Scabies is ...
(Date:9/2/2014)... 02, 2014 Michigan’s health care landscape ... Act and the Healthy Michigan Plan. Throughout these changes, ... a trusted funding resource for under-served individuals. Federal and ... or underinsured women between the ages of 50 and ... percent of the federal poverty level. , ...
(Date:9/2/2014)... Recently, Os-Monitor.com, an innovative company that provides many kinds ... employee internet monitoring products ( http://www.os-monitor.com ). Furthermore, the ... 10% off, on these useful items. , True ... different kinds of high end monitoring programs on its ... of all sizes. With its high end programs, the ...
Breaking Medicine News(10 mins):Health News:MyRounding Selected for Digital Health Venture Showcase Finals Top Three Startups Awarded $50,000 2Health News:New Breakthrough Formula - Dr. Scabies® : The New Industry Standard Treatment for Scabies to Fight the Scabies Breakout 2Health News:New Breakthrough Formula - Dr. Scabies® : The New Industry Standard Treatment for Scabies to Fight the Scabies Breakout 3Health News:New Breakthrough Formula - Dr. Scabies® : The New Industry Standard Treatment for Scabies to Fight the Scabies Breakout 4Health News:Local Affiliate of National Health Organization Continues 16-Year Tradition of Funding Programs to Help Fill Gaps in Breast Health Services for Under-Served Populations 2Health News:Local Affiliate of National Health Organization Continues 16-Year Tradition of Funding Programs to Help Fill Gaps in Breast Health Services for Under-Served Populations 3Health News:Useful Employee Internet Monitoring Products Now For Sale At Os-Monitor.com 2
... (sildenafil) can improve exercise capacity and functional ability in ... high pressure in the blood vessels that enter the ... report by Reuters, the findings, which appear in The ... study of 278 patients who were randomly selected to ...
... to stress during early life can lead to an ... adolescence.// It therefore, highlights the need for a counseling ... of growth. ,Several studies have established a ... with an increased risk of developing attachment disorders. These ...
... Death Syndrome (SIDS) has found out that nearly all cases ... a male sex hormone. //The levels are considerably higher in ... who have died suddenly from other causes. ,Researchers ... collected from 169 infants who had died of SIDS and ...
... findings were published by chemists at Harvard University, who ... they trigger could hold the key to oncogenesis,// the ... arises when an oncoprotien, a protein known to cause ... development of cancer, 'We present the hypothesis that an ...
... Research Institute have now found out that heart disease ... the thyroid gland.// Aggressive treatment of hypothyroidism and borderline ... diseases to a significant extent. ,The study has ... can be extrapolated to human beings as well. The ...
... of the National Cancer Institute conducted a meta-analysis of ... and the prevalence and associated mortality from colorectal cancer. ... of the Karolinska Institute in Stockholm, and colleagues. The ... at a 30 percent risk of developing colorectal cancer ...
Cached Medicine News:Health News:Teenage Mental Problems Could Be The Result Of Stress During Early Life 2Health News:Proper Treatment of Hypothyroidism Found To Prevent Heart Diseases 2
(Date:9/2/2014)... CARPINTERIA, Calif. , Sept. 2, 2014 ... assessments and penetration testing services, today released an IT ... industry. "Today,s healthcare CEOs are presiding over ... industry," said Daniel W. Berger , Redspin,s President ... help CEO,s and their Boards of Directors understand why ...
(Date:9/2/2014)... BEIJING , Sept. 2, 2014  Sinovac Biotech Ltd. ... products in China , today announced that ... in September: , Morgan Stanley Global Healthcare Conference, ... September 9 and 10, 2014. , Morgan Stanley Asia ... Hotel on September 11, 2014. , Aegis Healthcare & ...
(Date:9/2/2014)... Sept. 2, 2014  Drug delivery technologies that improve ... part of the entire drug development process. Pharmaceutical ... new vaccine delivery technologies in a bid to ... delivery procedures. New analysis from Frost ... the needle-free delivery sector currently makes up a ...
Breaking Medicine Technology:Sinovac to Participate in Upcoming Investor Conferences 2Needle-Free Delivery Devices Shape the Future of Vaccines, Says Frost & Sullivan 2Needle-Free Delivery Devices Shape the Future of Vaccines, Says Frost & Sullivan 3
The Buckle Apron has a 2" wide belt with a rugged side-release buck. The belt and buckle are adjustable to provide a snug and comfortable fit while still offering .50mm Pb protection....
Setting a new standard in protective apparel. The unique, patented Cool-Tech™ mesh-back design fits the natural contour of the body while reducing the amount of weight carried on the shoulders ...
Apron,special Proceddure...
Crisscross shoulder design facilitates better posture and distributes weight to back and hips for greater comfort. Shoulder pads soften shoulder contact with apron for additional comfort....
Medicine Products: