Navigation Links
Tulane Cancer Center to begin novel clinical trial for late-stage prostate cancer drug
Date:11/17/2009

International prostate cancer expert Dr. Oliver Sartor of Tulane Cancer Center is the first oncologist in the United States to offer patients an experimental new treatment for late-stage prostate cancer through a multi-center clinical trial that is currently recruiting patients at 100 sites across 20 countries worldwide.

The Cancer Center is seeking patients with advanced prostate cancer that has spread to the bones to take part in a phase III randomized clinical trial for Alpharadin (pronounced "Alpha-raydin"), an injectable treatment based on the radioactive substance Radium-223, an alpha-particle emitting pharmaceutical. All participants will receive the best available standard therapy and are randomized so that two-thirds of the subjects receive Alpharadin in addition. The other third of subjects will receive placebo along with the standard of care therapy. Early clinical trials of Alpharadin have suggested that it is well tolerated and that it might prolong survival for men whose prostate cancer is no longer responding to hormone therapy and has spread to the bones.

"Alpharadin appears to work by targeting and destroying cancer cells in the bone while sparing healthy bone marrow tissue," said Sartor, Piltz Professor of Cancer Research in the Departments of Medicine and Urology at Tulane University School of Medicine. "If successful in clinical trials, this compound could make a significant difference for the large number of men whose cancer has spread to the bones. Patients most often die as a consequence of the metastases not the primary cancer so preventing cancer from spreading and controlling cancer that has spread is a major clinical challenge."

According to the American Cancer Society, prostate cancer is the most frequently diagnosed cancer in men in the United States, affecting approximately one in six men each year; approximately 192,000 new cases will be diagnosed in 2009. Approximately 27,000 men in the United States die from prostate cancer each year and about 90 percent of these men have bone metastases.

Treatment options for men with metastatic prostate cancer of the bones are limited, and life expectancy, if left untreated, is an average 12 to 18 months. In addition, bone metastases can be very debilitating. Typically, patients with bone metastases experience severe bone pain, which increases as the metastasis grows, as well as other serious complications including neurological symptoms, fractures, severe anemia, or spinal cord compression. These complications can decrease patient quality of life and shorten life expectancy.


'/>"/>

Contact: Keith Brannon
kbrannon@tulane.edu
504-862-8789
Tulane University
Source:Eurekalert

Related medicine news :

1. High alcohol consumption increases stroke risk, Tulane study says
2. Tulane University to receive $14M for international HIV/AIDS program
3. Ruths Hospitality Group Inc. donates Broad Street building to Tulane
4. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
5. Survival differences by race most apparent in advanced stages of breast cancer
6. MRI finds breast cancer before it becomes dangerous
7. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
8. Pathway links inflammation, angiogenesis and breast cancer
9. Radiologists encouraged to look beyond cancer for clinically unseen diseases
10. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
11. Immune deficiency linked to a type of eye cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... December 02, 2016 , ... Metabolic Code ... to nutraceuticals and help doctors more efficiently manage their practice. Power2Practice is ... software platform for Integrative and Functional Medicine. , The Metabolic Code platform ...
(Date:12/4/2016)... ... December 03, 2016 , ... While James Earl Jones is known ... for in a show called "Front Page". One of the forthcoming episodes examines mammogram ... rates have plummeted in large part due to early detection. Like any other disease, ...
(Date:12/4/2016)... ... December 04, 2016 , ... ... new attractive animation styles with unique displacement design elements," said Christina Austin - ... third designs. Choose from a variety of design styles that include both left ...
(Date:12/4/2016)... (PRWEB) , ... December 04, 2016 , ... Responsible dental ... One must brush properly to achieve optimal results. This important necessity inspired an inventor ... need for a way to ensure that people break or avoid bad techniques of ...
(Date:12/2/2016)... Phoenix (PRWEB) , ... December 02, 2016 , ... ... statewide documentary on the perils of heroin that was watched live by 1 ... national Alfred I. duPont-Columbia University Award. , ASU students at the Walter Cronkite ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... The U.S. Food and Drug Administration today ... the risk of cardiovascular death in adult patients with ... "Cardiovascular disease is a leading cause of death ... Jean-Marc Guettier , M.D., C.M., director of the Division ... Drug Evaluation and Research. "Availability of antidiabetes therapies that ...
(Date:12/2/2016)... in the ECG Cables And ECG Leadwires Market owing to ... devices. On the other hand, the Asia-Pacific ... rate during the forecast period. The market players ... plc ( Ireland ), Koninklijke Philips N.V. ( ... ( China ), held major share of the ...
(Date:12/2/2016)... 2016 According to a ... by Product (Instruments, Reagents, Software), Technology (Immunoassay, Clinical ... Nephrology, Infectious Diseases) - Forecast to 2021" published ... USD 60.22 Billion in 2016. This market is ... during the forecast period (2016-2021) to reach USD ...
Breaking Medicine Technology: