Navigation Links
Tulane Cancer Center to begin novel clinical trial for late-stage prostate cancer drug
Date:11/17/2009

International prostate cancer expert Dr. Oliver Sartor of Tulane Cancer Center is the first oncologist in the United States to offer patients an experimental new treatment for late-stage prostate cancer through a multi-center clinical trial that is currently recruiting patients at 100 sites across 20 countries worldwide.

The Cancer Center is seeking patients with advanced prostate cancer that has spread to the bones to take part in a phase III randomized clinical trial for Alpharadin (pronounced "Alpha-raydin"), an injectable treatment based on the radioactive substance Radium-223, an alpha-particle emitting pharmaceutical. All participants will receive the best available standard therapy and are randomized so that two-thirds of the subjects receive Alpharadin in addition. The other third of subjects will receive placebo along with the standard of care therapy. Early clinical trials of Alpharadin have suggested that it is well tolerated and that it might prolong survival for men whose prostate cancer is no longer responding to hormone therapy and has spread to the bones.

"Alpharadin appears to work by targeting and destroying cancer cells in the bone while sparing healthy bone marrow tissue," said Sartor, Piltz Professor of Cancer Research in the Departments of Medicine and Urology at Tulane University School of Medicine. "If successful in clinical trials, this compound could make a significant difference for the large number of men whose cancer has spread to the bones. Patients most often die as a consequence of the metastases not the primary cancer so preventing cancer from spreading and controlling cancer that has spread is a major clinical challenge."

According to the American Cancer Society, prostate cancer is the most frequently diagnosed cancer in men in the United States, affecting approximately one in six men each year; approximately 192,000 new cases will be diagnosed in 2009. Approximately 27,000 men in the United States die from prostate cancer each year and about 90 percent of these men have bone metastases.

Treatment options for men with metastatic prostate cancer of the bones are limited, and life expectancy, if left untreated, is an average 12 to 18 months. In addition, bone metastases can be very debilitating. Typically, patients with bone metastases experience severe bone pain, which increases as the metastasis grows, as well as other serious complications including neurological symptoms, fractures, severe anemia, or spinal cord compression. These complications can decrease patient quality of life and shorten life expectancy.


'/>"/>

Contact: Keith Brannon
kbrannon@tulane.edu
504-862-8789
Tulane University
Source:Eurekalert

Related medicine news :

1. High alcohol consumption increases stroke risk, Tulane study says
2. Tulane University to receive $14M for international HIV/AIDS program
3. Ruths Hospitality Group Inc. donates Broad Street building to Tulane
4. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
5. Survival differences by race most apparent in advanced stages of breast cancer
6. MRI finds breast cancer before it becomes dangerous
7. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
8. Pathway links inflammation, angiogenesis and breast cancer
9. Radiologists encouraged to look beyond cancer for clinically unseen diseases
10. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
11. Immune deficiency linked to a type of eye cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... April 28, 2016 , ... Cosmetic Town, an online plastic ... . The forum section was recently revamped and upgraded to allow even more interaction ... use across the country. , According to the senior editor of Cosmetic Town, “We ...
(Date:4/28/2016)... ... ... In many parts of the world, contamination from human waste is a ... in underdeveloped parts of Africa where clean sources of food and water are scarce. ... will examine this global health issue and consider how it compares to other major ...
(Date:4/28/2016)... , ... April 28, 2016 ... ... provider of enterprise Data Center Infrastructure Management solutions, announces today the availability ... feature enhancements in the area of capacity management and optimization, providing new ...
(Date:4/28/2016)... Texas (PRWEB) , ... April 28, 2016 , ... Amada ... opened its newest office in San Antonio – its San Antonio West location. Prior ... years in medical device sales. The grand opening of Amada San Antonio West will ...
(Date:4/28/2016)... ... April 28, 2016 , ... Anzu®, ... announced a new Residency Education & Collaboration Platform for hospitals and medical ... and a host of collaboration tools designed to improve patient outcomes through ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... PUNE, India , April 28, 2016 /PRNewswire/ ... - Pipeline Review, H1 2016" is a report ... pipeline and helps strengthen R&D pipelines by identifying ... best-in-class products. Company Profiles discussed in ... Menarini Industrie Farmaceutiche Riunite Srl, AbbVie Inc., Abiogen ...
(Date:4/27/2016)... , April 27, 2016 ... accelerator (MR-linac) platform will be the focal point of ... of the European Society for Radiotherapy & Oncology, taking ... MR-linac integrates a state-of-the-art radiotherapy system and a high-field ... to clearly see the patient,s anatomy in real time. ...
(Date:4/27/2016)... , April 27, 2016 Shire ... Jeff Poulton , Chief Financial Officer, will present at ... Boston, MA on Wednesday, May 04, 2016, ... webcast will be available on the Presentations and Webcasts section ... replay of the webcast will be available on this same ...
Breaking Medicine Technology: