Navigation Links
Tugging on the 'malignant' switch
Date:6/16/2014

related genes, and activity of the PI3K pathway that is known to drive cell proliferation and invasion increased.

"The invasive structures we observed in our stiff matrices resemble the morphology of early-stage invasive ductal carcinoma. They also show increased expression of the estrogen receptor alpha [ER+] gene that drives cell division," says Koshy. "It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them."

But while stiffness is a key part of the story, it is not the full story. Further experiments indicated that the cells would recover their normal behavior in high-stiffness gels if they were exposed to increasing concentrations of laminin, a protein naturally found in the basement membrane.

When the extracellular matrix is very flexible, or when a high concentration of laminin is readily available, proteins called α6β4 integrins within the cell membrane bind with laminin to form small structures called hemidesmosomes, which anchor the epithelial cells to the basement membrane. But fluorescence microscopy revealed that the cells in a stiff matrix were not forming hemidesmosomes at all, so Mooney's team hypothesized that a stiffer matrix and a shortage of laminin was leaving the α6β4 integrins with dangling, unbound tails.

The team's final experiments demonstrated that these unbound integrin tails, indeed, get up to no good: they participate in the activation of two key biochemical pathways (PI3K and Rac1) that are necessary and sufficient to induce malignant cell behaviors in the in vitro epithelial tissue.

"If further studies validate that these processes are critical in human breast cancers," Koshy notes, "the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling
'/>"/>

Contact: Caroline Perry
cperry@seas.harvard.edu
Harvard University
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Malignant cells adopt a different pathway for genome duplication
2. New immunotherapy for malignant brain tumors
3. Bone growth factor may increase benign tumors but not malignant cancer
4. Researchers find potential new target to treat malignant pleural mesothelioma
5. Thwarting protein production slows cancer cells malignant march
6. New chemical probe provides tool to investigate role of malignant brain tumor domains
7. Study identifies growth factor essential to the most common malignant pediatric brain tumor
8. Researchers discover new mutations driving malignant melanoma
9. Enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia
10. Study pinpoints malignant mesothelioma patients likely to benefit from drug pemetrexed
11. Multiple Brain Tumors Even More Malignant: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tugging on the 'malignant' switch
(Date:7/31/2015)... ... July 31, 2015 , ... When the weather turned hot ... their new type of sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) ... To commemorate introduction of this new type of sod, Super-Sod is giving away red ...
(Date:7/31/2015)... (PRWEB) , ... August 01, 2015 , ... Super Bowl 50 will emanate ... Football League’s biggest day each year is the Super Bowl. In the two weeks that ... place from the host venue. The 2016 Super Bowl game will mark the 50th time ...
(Date:7/31/2015)... ... July 31, 2015 , ... Precision Aesthetics is New York’s only Thermage ... also the first provider of Exilis non-surgical fat reduction in New York. Due ... attracted a large International clientele. Many patients travel to New York to get ...
(Date:7/31/2015)... Alexandria, VA (PRWEB) , ... July 31, 2015 ... ... Foundation) introduced its new store run by GoodThreads. The store can be accessed ... products and designs, many of which are customizable. The best part: whenever a ...
(Date:7/31/2015)... , ... July 31, 2015 , ... Sculpted Contours Luxury ... CoolSmooth PRO this week. Zeltiq Aesthetics released this new applicator in the United ... 2014 for treating the outer thighs. The original applicator required a 2 hour ...
Breaking Medicine News(10 mins):Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 3
... Australia, April 20 Progen Pharmaceuticals Limited (ASX: PGL; ... that shows its epigenetic technology successfully inhibits tumor ... Progen,s collaborators at the 100th Annual American Association ... was effective in ,switching on, important anti-cancer genes ...
... with the power and influence to improve the healthcare ... to reform the nation,s healthcare system dominate Modern ... Healthcare for 2009. Among those making the list are ... Services Department; Nancy-Ann DeParle, director of the newly created ...
... - A national team of researchers led by Mayo Clinic ... more likely to have similar DNA changes or variants in ... have the cancer. , The findings, being presented at the ... an independent validation of an earlier European study that found ...
... Southern California have identified a new drug compound that ... without the negative side effects typically associated with Cox-2 ... to have a strong anti-tumor effect while also attacking ... tumor growth, according to data presented at the AACR ...
... Universal Health Realty Income Trust (NYSE: UHT ) ... C. Stein as a Trustee. Mr. Stein becomes the seventh ... Trustee. Mr. Stein, 50, is currently president and ... real estate company specializing in the acquisition, development, leasing and ...
... to Provide Free Counseling to Military Members, Veterans, and ... is honoring National Volunteer Week (April 19-25, 2009) with ... professionals to join the Give an Hour(TM) network to ... Hour(TM) is a nonprofit organization that has created a ...
Cached Medicine News:Health News:Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth 2Health News:Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth 3Health News:Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth 4Health News:Health Reformers Dominate Magazine's List of the Top 25 Women in Healthcare 2Health News:Mayo Clinic-led researchers confirm gene variants associated with the most common adult leukemia 2Health News:USC researchers develop new drug to target tumor cells and blood vessels 2Health News:Give an Hour(TM) Honors National Volunteer Week with Call to Service 2
(Date:7/31/2015)...  Boston Children,s Hospital physicians report the first ... their anatomy before undergoing high-risk brain procedures. The ... the brain,s blood vessels) that posed special treatment ... Journal of Neurosurgery: Pediatrics , the physicians ... resins to create custom, high-fidelity models of the ...
(Date:7/31/2015)... 31, 2015  Xcelience, a contract development and ... made a structured cash investment in Powdersize, a ... milling, micronization and powder size classification within the ... business while simultaneously adding a complete set of ... capabilities. "As we continue to ...
(Date:7/31/2015)... , July 31, 2015 Egalet ... integrated specialty pharmaceutical company focused on developing, manufacturing ... closing of its previously announced underwritten public offering ... a public offering price of $11.25 per share. ... included 1,000,000 shares issued upon the exercise in ...
Breaking Medicine Technology:3D Printing Helps Doctors Rehearse Complex Brain Procedures 23D Printing Helps Doctors Rehearse Complex Brain Procedures 33D Printing Helps Doctors Rehearse Complex Brain Procedures 4Xcelience Makes Structured Cash Investment in Powdersize 2Xcelience Makes Structured Cash Investment in Powdersize 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4
Conforms to the convexity of the lens providing easier access to anterior capsule. Reduces pontential of corneal touch. 25G x 5/8in (.50 x 16mm)...
... designed for LASIK surgery and other ... irrigate the corneal interface and/or stromal ... under the flap and helps elevate ... multi-directional irrigation. Two 25G (.50mm) parallel ...
... product designed for LASIK surgery and ... to irrigate the corneal interface and/or ... insertion under the flap and helps ... provide multi-directional irrigation. 25G x 7/8in ...
Cannula tip is specially rounded, extra smooth for safe insertion through wound and manipulation in the anterior chamber. 23G x 7/8 in (.60 x 22mm). .3mm end port. Olive shape tip is 2mm long x 1mm w...
Medicine Products: