Navigation Links
Tugging on the 'malignant' switch
Date:6/16/2014

related genes, and activity of the PI3K pathway that is known to drive cell proliferation and invasion increased.

"The invasive structures we observed in our stiff matrices resemble the morphology of early-stage invasive ductal carcinoma. They also show increased expression of the estrogen receptor alpha [ER+] gene that drives cell division," says Koshy. "It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them."

But while stiffness is a key part of the story, it is not the full story. Further experiments indicated that the cells would recover their normal behavior in high-stiffness gels if they were exposed to increasing concentrations of laminin, a protein naturally found in the basement membrane.

When the extracellular matrix is very flexible, or when a high concentration of laminin is readily available, proteins called α6β4 integrins within the cell membrane bind with laminin to form small structures called hemidesmosomes, which anchor the epithelial cells to the basement membrane. But fluorescence microscopy revealed that the cells in a stiff matrix were not forming hemidesmosomes at all, so Mooney's team hypothesized that a stiffer matrix and a shortage of laminin was leaving the α6β4 integrins with dangling, unbound tails.

The team's final experiments demonstrated that these unbound integrin tails, indeed, get up to no good: they participate in the activation of two key biochemical pathways (PI3K and Rac1) that are necessary and sufficient to induce malignant cell behaviors in the in vitro epithelial tissue.

"If further studies validate that these processes are critical in human breast cancers," Koshy notes, "the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling
'/>"/>

Contact: Caroline Perry
cperry@seas.harvard.edu
Harvard University
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Malignant cells adopt a different pathway for genome duplication
2. New immunotherapy for malignant brain tumors
3. Bone growth factor may increase benign tumors but not malignant cancer
4. Researchers find potential new target to treat malignant pleural mesothelioma
5. Thwarting protein production slows cancer cells malignant march
6. New chemical probe provides tool to investigate role of malignant brain tumor domains
7. Study identifies growth factor essential to the most common malignant pediatric brain tumor
8. Researchers discover new mutations driving malignant melanoma
9. Enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia
10. Study pinpoints malignant mesothelioma patients likely to benefit from drug pemetrexed
11. Multiple Brain Tumors Even More Malignant: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tugging on the 'malignant' switch
(Date:9/30/2014)... By Alan Mozes ... 2014 (HealthDay News) -- Colon cancer patients who are ... slightly higher risk for developing a second weight-related cancer, ... to the risk of colon cancer recurrence, only the ... , "We found that colorectal cancer survivors who reported ...
(Date:9/30/2014)... leading cause of cancer death in women, according to ... professionals encourage women to get mammograms, even though the ... suspicious mammograms actually leads to a cancer diagnosis. , ... and their familiesnot to mention the time, discomfort and ... , Recently, a different type of test, ultrasound elastography, ...
(Date:9/30/2014)... September 30, 2014 Keystone Symposia will convene ... first in its 2014-15 Global Health Series on ... Sheraton Seattle Hotel immediately following the conclusion of ... four-day conference is part of the Keystone Symposia Global ... Foundation, which has also funded travel awards for 36 ...
(Date:9/30/2014)... 30, 2014 A new study ... studied the impact of stress on metabolism after eating a ... fries from a fast food restaurant, about 930 calories and ... for 20 minutes every hour for 7 hours, conducting the ... women who had experienced a stressful event in their lives ...
(Date:9/30/2014)... Integrated Medicine Alliance , Monmouth ... new medical specialty practice through a unique partnership with ... be located within the company’s Shrewsbury location and will ... Tawfik of American Heart Center, P.C., a highly regarded ... offer Integrated Medicine Alliance patients top notch cardiovascular care ...
Breaking Medicine News(10 mins):Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 2Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 3Health News:'Virtual breast' could improve cancer detection 2Health News:Keystone Symposia launches 2014-2015 meeting series with Global Health Vaccines Conference 2Health News:NutriGold Urges Every Woman To Read a Recent Study About Diet and Stress 2Health News:NutriGold Urges Every Woman To Read a Recent Study About Diet and Stress 3Health News:Integrated Medicine Alliance Announces New Cardiology Practice 2
... This year, Baylor Health,Care System ranked 15th on ... that tracks information technology providers across,the country. No ... "Since innovation is one the Baylor Health Care ... recognize us for living our values,",says David Muntz, ...
... OF FEMALE WINEMAKERS AND FINE CUISINE IN ... CHARITIES, Robin Leach to host the event and Sopranos star and winemaker Lorraine ... Bracco to showcase Bracco Wines Michael Schulson star of Style ... restaurants go ...
... 18 Four Rivers Software Systems, Inc.,the ... the healthcare industry, combines departments under Samantha ... In her most recent position as ... directed the implementation and services division. Now,as ...
... Kicks Off Sector-Wide Initiative, OAKLAND, Calif., Oct. ... and environmentally responsible purchasing, has partnered,with a group ... green,practices across the industry. As a founding ... Kaiser,Permanente aims to share best practices and help ...
... Diabetes Alliance --, WESTPORT, Conn., Oct. 18 ... Day Diabetes Alliance with dLife, the only,integrated multimedia education ... an estimated 20.8 million(1) people in the United States,currently ... those,undiagnosed. The goal of the 360 degrees/365 Program is ...
... YORK, Oct. 18 The Jericho Project, a ... announced its,plan to launch a supportive housing program ... nearly 25-year experience in enabling,homeless individuals to become ... will feature a specially-built residence offering,housing and holistic ...
Cached Medicine News:Health News:Baylor Health Care System Receives National Information Technology Recognition 2Health News:Borgata Heart & Soul Foundation Presents Third Annual Women in Wine Event 2Health News:Borgata Heart & Soul Foundation Presents Third Annual Women in Wine Event 3Health News:Borgata Heart & Soul Foundation Presents Third Annual Women in Wine Event 4Health News:Four Rivers Software Systems, Inc. Announces the Promotion of Samantha Rouse to Senior Vice President of Product and Services 2Health News:Kaiser Permanente Joins With Top Health Care Groups to Create Healthier Hospital Environments 2Health News:Kaiser Permanente Joins With Top Health Care Groups to Create Healthier Hospital Environments 3Health News:Rite Aid and dLife Partner to Educate and Support Diabetes Community 2Health News:Rite Aid and dLife Partner to Educate and Support Diabetes Community 3Health News:The Jericho Project Announces Rehabilitation Residence for Homeless and Low-Income Veterans 2
(Date:9/30/2014)... LOS ANGELES , Sept. 30, 2014   ... apnea shopping destination , today announced that it now ... ResMed . AirSense CPAPs are the first sleep apnea ... makes it simple and easy to track and share ... the overall effectiveness of their CPAP therapy.  In addition, ...
(Date:9/30/2014)... BRUNSWICK, N.J., Sept. 30, 2014 The ... Kessler Foundation and New Jersey Health Foundation (NJHF) ... and patient care programs has been announced by ... officer of Kessler Foundation and James M. ... "The experience of New Jersey Health ...
(Date:9/30/2014)... -- The Eastern European medical device industry is in ... as new medical-device manufacturers are constantly trying to penetrate ... to reduce the cost incurred for placing their products ... effective means to achieve this target. This research service ... and provides profiles of key distributors in ...
Breaking Medicine Technology:Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 2Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 3Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 4Kessler Foundation Partners with New Jersey Health Foundation To Start Innovative Companies To Change the Lives of People with Disabilities 2Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3
... DIEGO, Aug. 28 Vical Incorporated,(Nasdaq: VICL ... subject in its,Phase 1 trial of the company,s ... placebo-controlled trial will,evaluate safety, tolerability and immune responses ... 45 at two U.S. clinical sites. "We ...
... such ... infectious-disease outbreaks, SEATTLE, Aug. 28 In ... Fred,Hutchinson Cancer Research Center confirm that the avian influenza A ... within a family in,Indonesia. The findings, by biostatistician Ira M. ...
Cached Medicine Technology:Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza 2Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza 3Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza 4Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 2Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 3Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006 4
... who need punctal occlusion want ... relief. They also want their ... comfortable and as unobtrusive as ... punctal plugs are growing in ...
... Only Heartlab delivers the ... today's cardiovascular information management systems. ... products and services set the ... innovative functionality, high-speed performance and ...
Precision near-field imaging combined with the best handling IVUS catheter....
Full Digital Color Ultrasound...
Medicine Products: