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Tufts researcher leads revision of osteoporosis guidelines
Date:6/5/2008

at Tufts University School of Medicine. "The new U.S.-adapted FRAX will help identify high-risk subgroups of men and non-Caucasian women and, we hope, a wider population of patients at risk for osteoporosis will be treated. Use of FRAX in men and non-Caucasian women will require adjustments in their T-scores that currently appear on bone density reports. "

Additionally, FRAX and the new Clinician's Guide address the cost-effectiveness of prescribing medication to patients with low bone mass, but not osteoporosis. Dawson-Hughes and colleagues performed an economic analysis that calls for treating patients with a 10-year hip fracture risk of 3 percent or greater or a major fracture risk of 20 percent or greater. That would include; patients with fragility fractures or osteoporosis, older patients at risk for osteoporosis and younger patients presenting additional clinical risk factors for fracture. FRAX is applicable to men and women over age 50, but not to younger people.

"The ability to estimate 10-year fracture risk is a crucial development in osteoporosis care, but it is still important for clinicians to review patient cases on an individual basis," says Dawson-Hughes. "Ten-year fracture risk should be used as a guideline."

The following are some recommendations from the new Clinician's Guide:

  • BMD testing for women age 65 and older and men age 70 and older and in post-menopausal women age 50-70 who present with certain risk factors.

  • Treatment in postmenopausal women and in men age 50 and older with low bone mass at the femoral neck, total hip or spine and 10-year hip fracture probability of 3 percent or more, or, a 10-year major fracture risk of 20 percent or more based on the US-adapted WHO absolute fracture risk model.

  • Regular weight-bearing and muscle-strengthening exercise to reduce the risk of falls and fractures.

  • Advise on adequate amount
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Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences
Source:Eurekalert

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