Navigation Links
Tufts researcher leads revision of osteoporosis guidelines
Date:6/5/2008

Tufts University researcher Bess Dawson-Hughes, M.D., chaired the committee that recently updated the National Osteoporosis Foundation (NOF) Clinician's Guide to Prevention and Treatment of Osteoporosis. The new Clinician's Guide incorporates the World Health Organization (WHO) absolute fracture prediction algorithm (FRAX), a computer-based tool expected to increase the identification of patients at risk for osteoporosis.

"The introduction of the WHO's fracture prediction algorithm necessitated the revision of the Clinician's Guide," says Dawson-Hughes, director of the Bone Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. "The algorithm tells clinicians how likely a patient is to fracture a bone due to osteoporosis or low bone mass in the 10 years following examination, also known as 10-year fracture risk. This can help clinicians decide whether a patient needs to be treated or simply monitored."

Writing in the April 2008 issue of the journal Osteoporosis International, corresponding author Dawson-Hughes and colleagues describe how to apply FRAX in the United States. Clinicians estimate a patient's 10-year fracture risk using a computer program that considers bone mineral density (BMD) score, or T-score, and nine clinical risk factors including personal fracture history, family fracture history, weight, race and gender. Notably, FRAX and the new Clinician's Guide now apply to men over 50 and post-menopausal non-Caucasian women, including African-Americans, Asians and Latinas. Previous versions applied only to post-menopausal Caucasian women, the group at highest-risk for osteoporosis.

In their analysis, Dawson-Hughes and colleagues highlight the inclusion of men in the guide. "Post menopausal women remain the most vulnerable to osteoporotic fractures, yet clinicians should not overlook men because their fracture risk may be lower," says Dawson-Hughes, who is also a professor at Tufts University School of Medicine. "The new U.S.-adapted FRAX will help identify high-risk subgroups of men and non-Caucasian women and, we hope, a wider population of patients at risk for osteoporosis will be treated. Use of FRAX in men and non-Caucasian women will require adjustments in their T-scores that currently appear on bone density reports. "

Additionally, FRAX and the new Clinician's Guide address the cost-effectiveness of prescribing medication to patients with low bone mass, but not osteoporosis. Dawson-Hughes and colleagues performed an economic analysis that calls for treating patients with a 10-year hip fracture risk of 3 percent or greater or a major fracture risk of 20 percent or greater. That would include; patients with fragility fractures or osteoporosis, older patients at risk for osteoporosis and younger patients presenting additional clinical risk factors for fracture. FRAX is applicable to men and women over age 50, but not to younger people.

"The ability to estimate 10-year fracture risk is a crucial development in osteoporosis care, but it is still important for clinicians to review patient cases on an individual basis," says Dawson-Hughes. "Ten-year fracture risk should be used as a guideline."

The following are some recommendations from the new Clinician's Guide:

  • BMD testing for women age 65 and older and men age 70 and older and in post-menopausal women age 50-70 who present with certain risk factors.

  • Treatment in postmenopausal women and in men age 50 and older with low bone mass at the femoral neck, total hip or spine and 10-year hip fracture probability of 3 percent or more, or, a 10-year major fracture risk of 20 percent or more based on the US-adapted WHO absolute fracture risk model.

  • Regular weight-bearing and muscle-strengthening exercise to reduce the risk of falls and fractures.

  • Advise on adequate amounts of calcium (at least 1200 mg per day, including supplements (if necessary) and vitamin D (800 to 1000 IU per day of vitamin D for individuals at risk of insufficiency).

"We continue to stress the importance of taking calcium and vitamin D for optimal bone health," says Dawson-Hughes, who has published several papers on the subject. "Previous studies suggest these nutrients help strengthen bones which is beneficial for all adults, even those who show no signs of osteoporosis."


'/>"/>

Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences
Source:Eurekalert

Related medicine news :

1. John Mackey, Chairman and CEO of Whole Foods Market(R), and Ellen M. Zane, President and CEO, Tufts Medical Center and the Floating Hospital for Children, Offer Advice to Bentley Students at May 17 Commencement
2. Visage Imaging to Provide Fully Integrated Thin Client-Based Solution to Tufts Medical Center
3. ACM Partners With Tufts Associated Health Plans to Improve the Cost-effective Delivery of Home Infusion Services
4. Echo Therapeutics Announces Positive Results from Symphony(TM) Transdermal Continuous Glucose Monitoring System Study at Tufts Medical Center
5. Tufts University Review Finds Cranberries Support a Healthy Heart
6. Tufts researchers update their food guide pyramid for older adults
7. Success of Shape-Up Somerville Childhood Obesity Intervention to be Presented at the Friedman School Symposium at Tufts, October 29-31, 2007 - Boston
8. Researchers ID Inflammation-Fighting Pathway in Fat Cells
9. Virginia Tech researchers find human virus in chimpanzees
10. Researcher Finds Link Between Pregnancy and Tooth Loss
11. Brown researchers work toward ending cartilage loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... ... MadgeTech will be showcasing its line of data logging products , ... MadgeTech headquarters. With products sold in more than 100 countries around the world, MadgeTech ... , In 2012, NASA strategically set up 17 RHTemp101A MadgeTech data loggers around ...
(Date:5/26/2016)... ... May 26, 2016 , ... An April Gallup survey found rising health care ... of Sun Health Senior Living (SHSL) may not share those same worries ... prescription copays for the year, while holding the line on increasing their contributions, including ...
(Date:5/26/2016)... ... May 26, 2016 , ... Leadership of ... today announced the organization has earned its ISO 13485 certification, indicating the company’s ... with all rules and policies associated with ISO quality standard 13485. , ...
(Date:5/26/2016)... ... 2016 , ... North Cypress Medical Center hosted its 9th Annual ... With the help of community partners, the event organizers raised $45,000 for the ... service members and their families through health, wellness, and therapeutic support. , A ...
(Date:5/26/2016)... FL (PRWEB) , ... May 26, 2016 , ... The ... of events featuring guest speaker Dr. Adonis Maiquez MD, ABAARM. Dr. Adonis , ... and Regenerative Medicine, and a member of the Institute for Functional Medicine. , He ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 25, 2016 Digital Health Dialog, LLC ... by the US Patent and Trademark Office of ... proprietary processes for electronic opt-­in and processing of ... programs, HIPAA compliance and otherwise. Logo - ... "Our technology allows for individuals to ...
(Date:5/24/2016)... 24, 2016 Niederländische Chirurgen ... die es Ärzten erlaubt, ihre Expertise weltweit zu ... kombiniert Live Streaming mit einer Instant-Messaging-Funktion und der ... Mediziner in Europa, Afrika, Asien und den ... die Plattform registriert. Information und Weiterbildung   ...
(Date:5/24/2016)... May 24, 2016  Diana Russell suffers from a ... from the inside out.  This disease has put her ... her children and grandchildren to leave her home.  Because ... family cannot haul the wheelchair.  So if there is ... and Diana is left to wait for the bus. ...
Breaking Medicine Technology: