Navigation Links
Tufts receives patent for antibody treatment against hemolytic uremic syndrome
Date:2/28/2011

Grafton, Mass., February 28, 2011 Researchers at the Cummings School of Veterinary Medicine have received U.S. patent approval for an antibody-based treatment for Hemolytic Uremic Syndrome (HUS), a potentially fatal outcome of E. coli poisoning and the leading cause of kidney failure in children.

HUS is caused by the forms of E. coli that produce Shiga toxins and are responsible for about 100,000 annual cases of illness in the United States alone. Typically, individuals will develop bloody diarrhea and recoverhowever, 5-15 percent of children, the elderly and individuals whose immune systems are compromised may develop HUS in addition after several days.

The condition causes kidney damage and can lead to chronic, irreversible kidney dysfunction, which can be fatal. HUS can also cause damage to the central nervous system. There is currently no cure for the condition.

The condition is believed to be caused by one of the two types of Shiga toxin excreted by E. coli, known as Stx2 and Stx1. The Tufts approach to treating HUS, led by Dr. Saul Tzipori, director of the Cummings School's Division of Infectious Diseases, utilizes human monoclonal antibodies that seek out and bind to the Stx and, ultimately, neutralize it. In a 2004 study, Dr. Tzipori was able to show its efficacy both in vitro and in vivo using mice and pig models.

Other attempts to neutralize Stx have been attempted using other types of antibodieschimeric and humanizedwhere mouse antibodies are fused with parts of human antibodies. However, Tzipori and his colleagues utilized antibodies from transgenic mice specially bred to express human antibodiescreating a safer, longer-lasting, and more effective treatment, Tzipori says.

"In addition to the other benefits, utilizing this approach of generating human antibodies enabled us to create a large number of them from which to select," said Distinguished Professor of Microbiology and Infectious Diseases Dr. Saul Tzipori.

The patent is currently licensed to Sarasota, Fla.-based Lakewood-Amedex Inc.


'/>"/>

Contact: Tom Keppeler
508-839-7910
Tufts University, Health Sciences
Source:Eurekalert

Related medicine news :

1. Tufts Medical Center and Boston Medical Center Nurses Hold a Joint Informational Picket to Protest Unsafe Staffing and Practice Conditions
2. Impressive lineup of speakers at Tufts nutrition conference
3. Tufts researcher elected 2010 AAAS Fellow for work in superbugs and heat-stable vaccines
4. Tufts University calls for moderate approach to teaching personalized genomic testing
5. NACDD Receives Two-Year Grant From Merck & Co., Inc. to Improve Diabetes Education
6. Dr Yaghouti of Global Laser Vision Receives Patient's Choice Award for 2009
7. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
8. BestMassage.com Receives Award for Customer Trust
9. Corporate Wellness Firm Limeade Receives SAS 70 Type II Report
10. Oridion Receives Frost & Sullivan's 2010 Customer Value Enhancement Award
11. Special Olympics Georgia Receives Grant from The Home Depot Foundation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... , ... A recent report from the National Council on Teacher Quality (NCTQ) ... suggests, based on a review of GPA and SAT/ACT requirements at 221 institutions in ... It argues that this higher bar should be set by states, by the Council ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... Convention Center at 10 North Broadway Avenue, will be an educational and exciting ... practical instruction in the management of chronic pain. , Oklahoma is in a ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... firm serving the families and businesses of the Norwalk and Vermillion areas, ... Ohio Recovery Center (N.O.R.A.) is a nonprofit, community-based substance abuse prevention and ...
(Date:3/23/2017)... CA (PRWEB) , ... March 23, 2017 , ... ... funding investment in Los Angeles based healthcare technology company California Healthcom Group (CHG). ... into the US, and healthcare arena. With headquarters in California, CHG is a ...
(Date:3/23/2017)... ... , ... March 23, 2017 - Crawford Technologies announced today ... invoices, bills, statements and other correspondence when they have been lost or destroyed. ... print the documents and batch them for efficient handling. , Many organizations ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017  Interpace Diagnostics Group, Inc. (NASDAQ: ... integrated commercial company that provides clinically useful molecular ... it has entered into agreements to successfully restructure ... ("RedPath") and concurrently terminate its royalty and milestone ... debt to RedPath amounting to $9.34 million is ...
(Date:3/23/2017)... , March 23, 2017 A research ... market is expected to reach USD 7.2 billion by the ... Sample preparation is a procedure in which a sample is ... in most analytical procedures since the methods are often allowing ... one of the most shared procedures in the lab. In ...
(Date:3/23/2017)... CENTRO DE IMAGEM DIAGNOSTICOS S.A. (" Company ... Law 6,404/76 and Instruction 358/02 of the Brazilian Securities ... the market in general that it entered yesterday, as ... por Imagem Ltda. (" CDI "), into an agreement ... LTDA. (" Partnership " and " Acquisition "). ...
Breaking Medicine Technology: