Navigation Links
Tufts receives patent for antibody treatment against hemolytic uremic syndrome
Date:2/28/2011

Grafton, Mass., February 28, 2011 Researchers at the Cummings School of Veterinary Medicine have received U.S. patent approval for an antibody-based treatment for Hemolytic Uremic Syndrome (HUS), a potentially fatal outcome of E. coli poisoning and the leading cause of kidney failure in children.

HUS is caused by the forms of E. coli that produce Shiga toxins and are responsible for about 100,000 annual cases of illness in the United States alone. Typically, individuals will develop bloody diarrhea and recoverhowever, 5-15 percent of children, the elderly and individuals whose immune systems are compromised may develop HUS in addition after several days.

The condition causes kidney damage and can lead to chronic, irreversible kidney dysfunction, which can be fatal. HUS can also cause damage to the central nervous system. There is currently no cure for the condition.

The condition is believed to be caused by one of the two types of Shiga toxin excreted by E. coli, known as Stx2 and Stx1. The Tufts approach to treating HUS, led by Dr. Saul Tzipori, director of the Cummings School's Division of Infectious Diseases, utilizes human monoclonal antibodies that seek out and bind to the Stx and, ultimately, neutralize it. In a 2004 study, Dr. Tzipori was able to show its efficacy both in vitro and in vivo using mice and pig models.

Other attempts to neutralize Stx have been attempted using other types of antibodieschimeric and humanizedwhere mouse antibodies are fused with parts of human antibodies. However, Tzipori and his colleagues utilized antibodies from transgenic mice specially bred to express human antibodiescreating a safer, longer-lasting, and more effective treatment, Tzipori says.

"In addition to the other benefits, utilizing this approach of generating human antibodies enabled us to create a large number of them from which to select," said Distinguished Professor of Microbiology and Infectious Diseases Dr. Saul Tzipori.

The patent is currently licensed to Sarasota, Fla.-based Lakewood-Amedex Inc.


'/>"/>

Contact: Tom Keppeler
508-839-7910
Tufts University, Health Sciences
Source:Eurekalert

Related medicine news :

1. Tufts Medical Center and Boston Medical Center Nurses Hold a Joint Informational Picket to Protest Unsafe Staffing and Practice Conditions
2. Impressive lineup of speakers at Tufts nutrition conference
3. Tufts researcher elected 2010 AAAS Fellow for work in superbugs and heat-stable vaccines
4. Tufts University calls for moderate approach to teaching personalized genomic testing
5. NACDD Receives Two-Year Grant From Merck & Co., Inc. to Improve Diabetes Education
6. Dr Yaghouti of Global Laser Vision Receives Patient's Choice Award for 2009
7. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
8. BestMassage.com Receives Award for Customer Trust
9. Corporate Wellness Firm Limeade Receives SAS 70 Type II Report
10. Oridion Receives Frost & Sullivan's 2010 Customer Value Enhancement Award
11. Special Olympics Georgia Receives Grant from The Home Depot Foundation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Hair Restoration, has recently contributed a medical article to the newly revamped ... Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... -- Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an ... Puerto Rico , where the company ... Following a comprehensive onsite assessment, ... damage, temporary loss of power and minimal water damage ... operations have resumed, and the company expects to return ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
Breaking Medicine Technology: