Navigation Links
Tuberculosis increases the risk of lung cancer mortality in the elderly

ATS 2012, SAN FRANCISCO Tuberculosis independently predicts death from lung cancer in the elderly, according to a new study from researchers in Hong Kong.

"There is a high incidence of both tuberculosis and lung cancer among the elderly in Hong Kong," said lead author Chi Chiu Leung, MBBS, consultant chest physician in the Tuberculosis and Chest Service of the Department of Health of Hong Kong. "In our prospective follow-up study of a cohort of 61,239 subjects aged 65 years or older, we found that active tuberculosis was an independent predictor of lung cancer death after adjustment for a number of demographic and health-related factors."

The results will be presented at the ATS 2012 International Conference in San Francisco.

Study subjects were enrolled from 18 Elderly Health Centers of the Department of Health in Hong Kong between 2000 and 2003 and retrospectively cross-matched with 1993-2003 data from the tuberculosis notification registry. The cohort was followed prospectively through 2011 with causes of death ascertained through the territory-wide death registry.

Of 61,239 study subjects, 516 had active tuberculosis prior to study enrollment. During follow-up, there were 1,344 deaths from lung cancer, 910 deaths from other tobacco-related malignancies, and 2,003 deaths from non-tobacco-related malignancies.

After adjustment for gender, age, language spoken, education level, marital status, housing situation, public means-tested financial assistance status, ever-smoking status, passive smoking, alcohol use, body mass index, chronic obstructive pulmonary disease and/or asthma and family history of malignancy, having active tuberculosis before study enrollment was significantly associated with death from lung cancer but not with death form the other two categories of malignancies.

"The association between tuberculosis and lung cancer death in elderly patients in our study likely reflects the effect of tuberculosis on the occurrence of this cancer," said Dr. Leung. "Lung cancer mortality is increasing rapidly with the aging population in China and other Asian Countries. Our results call for greater attention to the possibility of lung cancer in patients with a history of tuberculosis and increased public health initiatives aimed at tobacco and tuberculosis control."

"With accumulating knowledge on risk factors other than cigarette smoking, attempts should be made to build a more comprehensive predictive model for lung cancer to target future screening activities," Dr. Leung concluded. "Further delineation of the underlying mechanisms may also help to identify potential drug targets for prevention and/or treatment of this important deadly disease."


Contact: Nathaniel Dunford
American Thoracic Society

Related medicine news :

1. Older people and those with HIV are more vulnerable to tuberculosis
2. UN Foundation President Timothy E. Wirth Commends African Leaders for Renewed Commitment to the Global Fund to Fight AIDS, Tuberculosis and Malaria
3. Major funding awarded to improve treatment of drug-resistant tuberculosis and HIV co-infection
4. A breakthrough in tuberculosis research
5. A*STAR and Institut Merieux/bioMerieux invest S$3m ($2.2m) in tuberculosis research
6. New genomic marker for tuberculosis may help identify patients who will develop the disease
7. New dual recognition mechanism discovered in tuberculosis
8. Einstein scientist awarded $4 million to develop genetic strategy to combat tuberculosis
9. Study finds evidence of increased lung cancer risk among tuberculosis patients
10. Homogeneous tuberculosis treatment ineffective in children, UT Southwestern researchers find
11. Death rate from tuberculosis in homeless alarmingly high: Study
Post Your Comments:
(Date:6/27/2016)... ... 2016 , ... The OSHA Training Center at Chabot-Las ... headquartered in Northern California, has issued an important reminder to employers to prevent ... Employers with workers exposed to high temperatures should establish a complete heat illness ...
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal ... Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Cut Pro X users can now reveal the media of their split screens ...
(Date:6/27/2016)... ... ... TherapySites, the leading website and online marketing ... Association. This new relationship allows TherapySites to continue to extend their online ... and promotional offers. , "TCA is extremely excited about this new partnership, as ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is ... emergency ambulance transport experience for the millions of people who require these medical ... the taxi industry through the use of technology. Now, SmartEMS has put forth ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 One of Australia,s successful ... of a new biotechnology company, Noxopharm Limited [ABN 50 608 966 ... and to list on the ASX. Noxopharm is a ... enter a Phase 1 clinical study later this year. ... of the biggest problems facing cancer patients - the ability of ...
(Date:6/26/2016)... 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ... Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) expired ... Time). As previously announced on May 31, ... merger agreement under which Jazz Pharmaceuticals has commenced a ...
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, ... Board will take whatever measures required to build a ... stock which is currently listed on the OTC Markets-pink ... Company Chairman and CEO, "We are seeing an anomaly ... to understand, not only by the Company, but shareholders ...
Breaking Medicine Technology: