Navigation Links
Tuberculosis genomes recovered from 200-year old Hungarian mummy
Date:7/19/2013

Researchers at the University of Warwick have recovered tuberculosis (TB) genomes from the lung tissue of a 215-year old mummy using a technique known as metagenomics.

The team, led by Professor Mark Pallen, Professor of Microbial Genomics at Warwick Medical School, working with Helen Donoghue at University College London and collaborators in Birmingham and Budapest, sought to use the technique to identify TB DNA in a historical specimen.

The term 'metagenomics' is used to describe the open-ended sequencing of DNA from samples without the need for culture or target-specific amplification or enrichment. This approach avoids the complex and unreliable workflows associated with culture of bacteria or amplification of DNA and draws on the remarkable throughput and ease of use of modern sequencing approaches.

The sample came from a Hungarian woman, Terzia Hausmann, who died aged 28 on 25 December 1797. Her mummified remains were recovered from a crypt in the town of Vc, Hungary. When the crypt was opened in 1994, it was found to contain the naturally mummified bodies of 242 people. Molecular analyses of the chest sample in a previous study confirmed the diagnosis of tuberculosis and hinted that TB DNA was extremely well preserved in her body.

Professor Pallen explained the importance of the breakthrough, "Most other attempts to recover DNA sequences from historical or ancient samples have suffered from the risk of contamination, because they rely on amplification of DNA in the laboratory, plus they have required onerous optimisation of target-specific assays. The beauty of metagenomics is that it provides a simple but highly informative, assumption-free, one-size-fits-all approach that works in a wide variety of contexts. A few months ago we showed that metagenomics allowed us to identify an E. coli outbreak strains from faecal samples and a few weeks ago a similar approach was shown by another group to deliver a leprosy genome
'/>"/>

Contact: Luke Harrison
luke.harrison@warwick.ac.uk
University of Warwick
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A better tool to diagnose tuberculosis
2. Tuberculosis increases the risk of lung cancer mortality in the elderly
3. Dartmouth medical research closes in on new tuberculosis vaccine
4. Alarming Rise Seen in Drug-Resistant Tuberculosis
5. Pain drug can kill resistant tuberculosis
6. Stroke drug kills bacteria that cause ulcers and tuberculosis
7. First anti-tuberculosis medicine under USAID-supported PQM program achieves WHO prequalification
8. Tuberculosis and neglected diseases targeted by new center
9. Request A Test Offers $10 off of Tuberculosis Testing this March
10. Genomes show how Staph bacteria gain resistance to last-line drug
11. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... ... July 02, 2015 , ... Denver-based SlimGenics Weight Control Centers, ... named No. 14 on ColoradoBiz magazine’s Top 100 Woman-Owned Companies list. ColoradoBiz compiles ... recognized. The award identifies outstanding woman-owned businesses that demonstrate excellence and success in ...
(Date:7/1/2015)... ... July 01, 2015 , ... With all final ... Health, located in Syracuse, N.Y., is now a member of national system Trinity ... admirable and important partner committed to delivering high-value care, said Richard J. Gilfillan, ...
(Date:7/1/2015)... ... July 01, 2015 , ... For decades, researchers in ... histones, remain constant in the brain, never changing after development in the womb. Now, ... are steadily replaced in brain cells throughout life – a process which helps to ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... ... technology and services, today announced that its fifth annual Smile for a Lifetime ... $80,000 for the non-profit organization. In addition to supporting S4L in its mission ...
(Date:7/1/2015)... York, NY (PRWEB) , ... July 01, 2015 , ... ... $100,000 from the New York Community Trust. The grant will allow CCF to improve ... sharing proven practices. , CCF was formed to respond to many changes in New ...
Breaking Medicine News(10 mins):Health News:ColoradoBiz Magazine Names SlimGenics #14 on Top 100 Woman-Owned Companies List 2Health News:ColoradoBiz Magazine Names SlimGenics #14 on Top 100 Woman-Owned Companies List 3Health News:St. Joseph’s Health Now a Member of Trinity Health 2Health News:St. Joseph’s Health Now a Member of Trinity Health 3Health News:St. Joseph’s Health Now a Member of Trinity Health 4Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 2Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 3Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 4Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 2Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 3Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 2Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 3
... Oct. 2 A doctor involved in a $7,million ... sentenced,to 18 months in prison, seven months home confinement, ... Fisher of the,Criminal Division and U.S. Attorney R. Alexander ... Dr. Orestes Alvarez-Jacinto, 80, was sentenced today by U.S. ...
... Ventas, Inc. (NYSE:,VTR) ("Ventas" or the "Company") said ... Compliance Committee member Ronald G. Geary to be Chair,of ... II,presiding director of the Board, to fill the vacancy ... Committee,s former Chair, Christopher T.,Hannon. The Company,s Audit ...
... 2 The American Dental,Association (ADA) has updated ... amalgam waste to include the use of separators,collection ... and,remove at least 95 percent of solid waste ... of separators will allow greater recycling and reduce,the ...
... screening method that allows for detection of polyps and ... during the same exam, BEFORE they progress into ... to the,American Society for Gastrointestinal Endoscopy (ASGE), colonoscopy remains,the ... accepted as the best method for colon cancer screening ...
... certain scores and patterns based on prostate cancer biopsy ... suggesting that this measurement could help predict the risk ... in the October 3 issue of JAMA. , One ... of prostate cancer is the Gleason scoring system, which ...
... Green, OAKLAND, Calif. Oct. 2 The ... today,recognized Kaiser Permanente as a "Green Electronics Champion" ... Permanente,was the only health care organization to receive ... The EPA, in conjunction with the Green ...
Cached Medicine News:Health News:Florida Doctor Sentenced to 18 Months in Prison for Medicare Fraud 2Health News:ADA Updates Environmental Recommendations for Handling Waste 2Health News:Colonoscopy Remains the Most Effective Screening Option for Colon Cancer 2Health News:Colonoscopy Remains the Most Effective Screening Option for Colon Cancer 3Health News:Colonoscopy Remains the Most Effective Screening Option for Colon Cancer 4Health News:Using additional biopsy-scoring data may help determine prostate cancer prognosis 2Health News:Kaiser Permanente Named Green Electronics Champion by EPA, Green Electronics Council 2Health News:Kaiser Permanente Named Green Electronics Champion by EPA, Green Electronics Council 3
(Date:7/1/2015)... , July 1, 2015 Eli Lilly and Company ... the second quarter of 2015 on Thursday, July 23, 2015. ... with the investment community and media to further detail the ... at 9 a.m. EDT. Investors, media and the general public ... a link that will be posted on Lilly,s website at ...
(Date:7/1/2015)... ISELIN, N.J. , July 1, 2015 /PRNewswire/ ... medical device company focused on non-invasive continuous glucose ... of its new and completely re-designed corporate website ... and intuitive access to Echo,s technology and enhances ... The new website better communicates to prospective ...
(Date:7/1/2015)... 2015 Dynatronics Corporation (the "Company") (NASDAQ: ... rehabilitation and physical therapy products, announced today that ... led by affiliates of Prettybrook Partners LLC (collectively, ... the healthcare industry. The financing provides Dynatronics with ... potential strategic acquisitions.  "We enthusiastically ...
Breaking Medicine Technology:Lilly Confirms Date and Conference Call for Second-Quarter 2015 Financial Results Announcement 2Echo Therapeutics Announces New Website Launch 2Echo Therapeutics Announces New Website Launch 3Dynatronics Announces Completion Of $4,025,000 Private Placement Led By Prettybrook Partners 2Dynatronics Announces Completion Of $4,025,000 Private Placement Led By Prettybrook Partners 3
... Mass., May 19, 2011 Alere Inc. (NYSE: ALR ... their health at home through the merger of rapid diagnostics and ... its Series B Convertible Perpetual Preferred Stock (NYSE: ALR ... Series B stock in an amount per share equal to the ...
... a segment of BD (Becton, Dickinson and Company) (NYSE: ... BD MAX™ for use as an open system. ... molecular system designed to perform a broad range of molecular ... but also user-defined protocols and life science research applications. The ...
Cached Medicine Technology:BD Launches BD MAX™ System in U.S. to Empower Laboratories and Clinicians to Respond to Emerging Diseases 2BD Launches BD MAX™ System in U.S. to Empower Laboratories and Clinicians to Respond to Emerging Diseases 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: