Navigation Links
Trying to halt hepatitis C's molecular hijacking
Date:12/27/2012

AURORA, Colo. (Dec. 27, 2012) Researchers at the University of Colorado School of Medicine have figured out intimate details of how the hepatitis C virus takes over an invaded cell, a breakthrough that could point to way for new treatments for the virus.

Hep C hijacks the machinery by which a cell makes proteins and uses it instead to create proteins for the virus. Over the last two decades, researchers have figured out that Hep C uses an RNA molecule to do this. Now they're trying to fill in the details.

One key detail is reported in a paper published online Dec. 23 in Nature Structural and Molecular Biology. It's written by Jeffrey Kieft, PhD, an associate professor at the CU medical school's Department of Biochemistry and Molecular Genetics and an Early Career Scientist of the Howard Hughes Medical Institute, and his former graduate student, Megan Filbin, PhD, a graduate of the Program in Molecular Biology.

Working with researchers from the lab of Tamir Gonen at the Janelia Farm Research Campus of the Howard Hughes Medical Institute, Kieft used ultra high-power electron microscopes to take images of individual RNA molecules from Hep C as they interacted with the cell's machinery. The researchers combined those images with a variety of other experiments and these clues led them to identify a new way that the virus' RNAs takes over the cell's machinery.

Specifically, the researchers focused on how a ribosome, the cell's protein-making factory, can be manipulated by the Hep C RNA to affect a part of the protein process called translocation. And they saw something else that even very small changes in the interactions important for that hijacking process can be blocked.

"This points the way to developing drugs to fight hepatitis C in ways that current therapies do not," Kieft says.


'/>"/>

Contact: Dan Meyers
dan.meyers@ucdenver.edu
303-724-5377
University of Colorado Denver
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Hepatitis C drug can cause depression
3. Gastroenterology special issue focuses on new directions of viral hepatitis care and research
4. Test Baby Boomers for Hepatitis C, Says CDC
5. Hepatitis C Causing Liver Damage in Greater Numbers: Study
6. 16th-century Korean mummy provides clue to hepatitis B virus genetic code
7. Hepatitis B Infection Rates in U.S. Higher Than Thought
8. Many Homeless May Harbor Hepatitis C
9. EASL-AASLD Special Conference on Therapy of Hepatitis C
10. Current and former smokers at risk for recurrent hepatitis post-liver transplantation
11. Hepatitis C Virus Levels Higher in Certain Injection Drug Users
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post ... insurance policy . , Auto insurance quotes help many ... no longer necessary to call an agent or visit an ... on a single website: http://autocarinsurancebest.com/ . , Every business ...
(Date:1/22/2015)... 2015 A study recently published ... journal Medicine & Science in Sports & Exercise ... help reduce gastrointestinal (GI) problems associated with physical ... in the double-blind, placebo-controlled study took 10 grams ...
(Date:1/22/2015)... Four years since the release of their debut recording Love ... of Avasa & Matthew Love – the duo are pleased to ... through White Swan Records on February 24, 2015. , THE ROAD ... available to all of us to walk out of the mire ...
(Date:1/22/2015)... January 22, 2015 JJsHouse.com is a famous ... Today, the business announces its latest collection of wedding ... “The most important issue is the wedding dress on your ... in a woman’s life. Every bride wants to find the ...
(Date:1/22/2015)... USA (PRWEB) January 22, 2015 State ... statewide data management system with support from GEOSYSTEMS, a ... The new solution will leverage Hexagon Geospatial’s ERDAS ... vector data as well as point clouds and documents. ...
Breaking Medicine News(10 mins):Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... on a transporter that actually quietens the body’s natural ... potent and non-habit //forming pain killers and will help ... ,Opioid peptides are natural pain relievers with receptors – ... the body, says Dr. Vadivel Ganapathy, chair of the ...
... on animal health has declared India as free from the ... intestinal tract of cattle //. ,'This recognition of ... It is the first animal disease to be officially recognised ... from India,' agriculture ministry said in a statement Friday. ...
... changing lifestyles has led to Himachal Pradesh having one of ... to a survey //. ,The latest countrywide findings of ... Pradesh out of every 100,000 people, 195 had a mental ... carried out after 11 years. ,Kerala has the ...
... Medical School it is said that a resistant bacteria was ... patients. // Pseudomonas aeruginosa (PA) is the bacteria which secretes ... Mougous, lead author of the study published in the June ... the host may be a cancer patient with a weakened ...
... doctors’ role in interrogating detainees, but ... a role, claiming that it can lead interrogaters’ to ... of medical advice. ,Medical professionals were used by ... lot of flak from human rights groups and medical ...
... popular excuse "not tonight, I have a headache," a ... activity and says that sexual desire and migraine may ... ,In fact, migraine sufferers reported higher levels of ... according to researchers from Wake Forest University School of ...
Cached Medicine News:Health News:Transporter offers reliable clues for safer pain medicine 2Health News:Transporter offers reliable clues for safer pain medicine 3Health News:India Declared Free of Rinderpest Cattle Infection 2Health News:Treatment of Bacterial Infection Paves the Way to Treat CF Infection 2Health News:Medical Role In Interrogations Curtailed By Pentagon 2
(Date:1/23/2015)... , Jan. 23, 2015  A new analysis of ... D 2015 enrollment data shows that 81 percent of ... access and extra discounts at certain pharmacies. The findings ... "Preferred pharmacy plans are now the foundation of Medicare ...
(Date:1/23/2015)... , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( ... of directors of Advaxis, Inc. ("Advaxis" or the "Company") ... has breached its fiduciary duties to shareholders. ... an investing website reporting that Advaxis had misrepresented the ...
(Date:1/23/2015)...  Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT), announced that the number ... lead compound, LB‑100, is being conducted, has been expanded from ... , M.D., the founder and President of Lixte, said that, ... single site. Accrual of patients, however, was slower than projected. ...
Breaking Medicine Technology:New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: