Navigation Links
Trudeau researchers identify unforeseen regulation of the anti-bacterial immune response
Date:8/28/2012

Saranac Lake, N.Y. August 28, 2012 New research from the laboratory of Dr. Andrea Cooper at the Trudeau Institute, just published in the European Journal of Immunology, holds promise for the improved prevention and treatment of bacterial infections and the life-threatening complications of chronic inflammation that can result from them. The publication title is "Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection".

Following a typical bacterial infection, the immune response is manifested by the accumulation of immune cells within the affected organs. In a bacterial skin infection, for example, this accumulation results in swelling and redness. When infection occurs in internal organs, a similar type of response takes place, but in this setting the immune response can actually damage the organs, resulting in their diminished function. Because of this risk, whenever the immune response acts to control bacteria, the response itself must also be regulated to prevent patient injury.

The publication defines the role of a specific component of the immune response in controlling the extent of the immune response. The authors show that cells that promote damaging inflammation are specifically regulated by the activated immune cells that are part of the inflammatory process. In this way, the immune response undergoes a negative feedback loop that regulates tissue damage but can also limit the expression of bacterial control.

Once bacteria enter the body, the disease process can occur in one of two ways: either the bacteria manipulates the immune regulatory pathways, limiting expression of an immune response (leading to too many bacteria and resulting in tissue damage), or the immune response is not well regulated, and the subsequent inflammatory response damages organs. Maintaining the balance between the killing of bacteria and regulation of the immune response is critical to the health of the patient. The better our understanding of how this balance is generated, the more easily the immune response can be manipulated to achieve an optimal outcome every time it is induced.


'/>"/>

Contact: Kim Godreau
kgodreau@trudeauinstitute.org
518-891-3080
Trudeau Institute
Source:Eurekalert  

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Trudeau researchers identify unforeseen regulation of the anti-bacterial immune response
(Date:2/13/2016)... ... 2016 , ... DDi , a Makro company, makes ... its expertise in eClinical Solutions. DDi has built its solution competency with a ... global clients. DDi provides smarter technology for Clinical Development, Regulatory and Enterprise domains ...
(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of ... Evangeline Parishes. The purpose of these scholarships is to encourage applicants to pursue ... to seek employment within these two parishes. , “We have available jobs in ...
(Date:2/12/2016)... Falls Church, VA (PRWEB) , ... February 12, 2016 , ... CDRH Enforcement Trends: , ... http://www.fdanews.com/cdrhenforcementtrends , As Winston Churchill said, “Those who don’t learn ... 2015 will show what to expect when they come knocking this year. But that takes ...
(Date:2/12/2016)... Angeles, CA (PRWEB) , ... February 12, 2016 , ... ... With a hectic schedule, a demanding job, and no time to decompress, Rabinowitz found ... she dedicated herself to meditation for its impact on her life, implementing a 20-minute-per-day ...
(Date:2/12/2016)... ... February 12, 2016 , ... The ... Zuckerberg San Francisco General Hospital on April 5-7. The series is a multi-day, ... new habits. The workshops cover a broad range of topics, including coaching skills, ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016  Sequent Medical, Inc. announced today that ... evaluate the safety and effectiveness of the WEB™ Aneurysm ... intracranial aneurysms.  Prof Laurent Spelle , MD, Head ... Paris, France and Principal Investigator of the ... France and Germany.  Although patients with ruptured ...
(Date:2/12/2016)... 2016  OMS Supply, a large provider of oral ... today the recent launching of their new company website. ... features that enhance the user experience and enable practitioners ... --> --> Despite the ... that started in early 2016, they have already made ...
(Date:2/11/2016)... Feb. 11, 2016 - ... in Personalized Medicine and Cancer Therapy. - European ... Diagnostic Testing Markets. - Key Diagnostic Testing Markets. ... Molecular Diagnostics in Genetic Testing. - Molecular Diagnostics ... - Over-the-Counter Diagnostic Products World Markets. - ...
Breaking Medicine Technology: