Navigation Links
Trudeau Institute reports new approach to treating Listeria infections
Date:10/17/2011

a. He discovered that activated macrophages play a critical role in killing Listeria. He also discovered that lymphocytes, another type of immune cell, orchestrate this killing response. These seminal observations remain the foundation for modern studies of cell-mediated defense against pathogens.

The Trudeau Institute's second director, Dr. Robert J. North, extended this work by identifying the key subset of anti-Listeria lymphocytes: T cells. Dr. North and his Trudeau colleagues also described crucial roles for NK cells and neutrophils.

Several years ago, Dr. Smiley discovered that blood-clotting proteins also play critical protective roles during immune defense against Listeria. "I was really intrigued by our finding that clotting protects against Listeria because so many other studies had shown that clotting clogs blood vessels and contributes to organ failure and death during septic infections," said Dr. Smiley.

"Our finding suggested that some degree of blood clotting is essential for effective immune defense, but too much is harmful. We set out in search of ways to prevent the bad clotting while maintaining the good."

Specifically, Dr. Smiley's lab looked for clotting factors that appeared to be hyperactive in the septic state.

"The paper we've just published is our first demonstration of this exciting new approach to treating sepsis we found that FXI is overproduced during septic Listeria infections and that therapeutics targeting FXI can reduce septic disease while maintaining immune defense."


'/>"/>

Contact: Kim Godreau
kgodreau@trudeauinstitute.org
518-891-3080 x561
Trudeau Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Hebrew SeniorLifes Dr. Sharon K. Inouye elected to Institute of Medicine
2. Terry Fox Research Institute aims to change diagnosis and management of ovarian cancer worldwide
3. Austen BioInnovation Institutes Accountable Care Community initiative gains national support
4. National Cancer Institute establishes $11.3 million center at Case Western Reserve
5. Institute for Aging Research study finds Bostons elderly homeless sicker than others
6. Society of Interventional Radiology Foundation funds Howard Hughes Medical Institute Award
7. Scripps Translational Science Institute joins Jackson Laboratory tumor consortium
8. Van Andel Research Institute finding could lead to reduced side effects in anti-cancer antibiotics
9. TGen, Tecan and ASU Biodesign Institute develop sample preparation solution for proteomic research
10. Stanford Woods Institute awards Environmental Venture Projects
11. UC Riverside botanist receives high honor from Howard Hughes Medical Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... International efforts to combat ... are receiving further support from recent initiatives ... (NGOs) and other charitable organizations. While research ... responders, patients and others can immediately benefit ... CmTP MediDefense system , which includes ...
(Date:12/22/2014)... Physicians in China are most eagerly ... of non-Hodgkin’s lymphoma (NHL), according to a new report ... consulting firm. MabThera is the only biologic available to ... form of NHL. , According to Kantar Health’s report, ... of NHL in China has been growing and is ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Explorys, the ... additions to its leadership team: Greg Yarrington as Vice ... Engineering, and Patrick Wells as Vice President of Solutions. ... add 80 new jobs in 2015 to support client ... of its platform-as-a-service offerings, and growth of its partner ...
(Date:12/22/2014)... December 22, 2014 In recognition of ... sales to Hero Reward, a local organization that provides ... , Located on a couple hundred acres ... Program offers lodging, world class fishing, hunting, hiking, horseback ... was founded several years ago to support U.S. Service ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Xarelto ... federal panel of judges has granted a request to ... the U.S. District Court, Eastern District of Louisiana. The ... order on December 12 to transfer over 50 Xarelto ... districts to the Louisiana court for consolidation under U.S. ...
Breaking Medicine News(10 mins):Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 2Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 3Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 4Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 5Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 2Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 3Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 3Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 4
... Boys are twice as,likely as girls in the ... hormone (rhGH) for growth hormone deficiency, illnesses that,affect height, ... gender,difference exists in Europe, Australia and New Zealand, but ... are treated at the same rate. This indicates,a likely ...
... Spanish . , A group of scientists from the ... of the University of Granada have found out ... to obtain inhibitors of neurogenic vasodilatation, a significant progress in migraine ... del Mar Herrador and Alejandro Fernndez Barrero , has ...
... obstetrical data management system integrates system, reliability, improves ... initiatives to help drive improved ... ... 17 Hill-Rom (NYSE:,HRC) today announced the release of an ...
... LIVINGSTON, N.J., April 17 MM2 Group, Inc.,(OTC ... Genotec Nutritionals, Inc., a New York based nutraceutical,company ... its branded,products and through custom formulations for several ... for the manufacture of,fish oil sofgels. The sofgels ...
... approach that combines comprehensive gene expression profiling with genome-wide ... to an important genetic marker that can help physicians ... and will require more aggressive treatment, a research team ... in the April 15, 2008, issue of the journal ...
... Activity, DALLAS, April 17 ACCESS ... from preclinical studies,ongoing at the prestigious Imperial ... antibody. The new data, presented by Dr.,Mahendra ... that Angiolix has unusually high accumulation in ...
Cached Medicine News:Health News:Growth Hormone is Used to Treat Twice as Many Short Boys Than Girls in the U.S. and Asia; Gender Difference is Smaller in the Rest of the World 2Health News:Growth Hormone is Used to Treat Twice as Many Short Boys Than Girls in the U.S. and Asia; Gender Difference is Smaller in the Rest of the World 3Health News:Growth Hormone is Used to Treat Twice as Many Short Boys Than Girls in the U.S. and Asia; Gender Difference is Smaller in the Rest of the World 4Health News:Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean 2Health News:Hill-Rom's NaviCare(R) WatchChild(R) Solution Provides Enhanced Information Technology Solutions for Obstetrical Care 2Health News:MM2 Group Provides Additional Quotes for New Venture in China 2Health News:Genome analysis reveals new protein associated with breast cancer progression 2Health News:Access Pharmaceuticals Announces New Data on Angiolix(R) 2Health News:Access Pharmaceuticals Announces New Data on Angiolix(R) 3
(Date:12/19/2014)... , Dec. 19, 2014  Advanced Medical ... development company engaged primarily in the development of ... therapeutic applications, today announced that a Life Sciences ... been awarded for which AMIC is the commercialization ... University (WSU) for the proposal titled "Optimized Injectable ...
(Date:12/19/2014)... 19, 2014 In today,s rapidly changing, ... communication tools are essential for survival. The world ... consumers, desires, preferences, and unmet needs are evolving ... groups across all industries are continually searching for ... the adoption of new market research techniques like ...
(Date:12/19/2014)... 18, 2014 Somewhere between dropping five pounds ... forgotten. But Audicus , a next-generation hearing aids ... new year. Hearing loss is the third ... though it is often unaddressed. Forty-eight million Americans have ... hearing aid, mainly due to price. Hearing aids traditionally ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 2Advanced Medical Isotope Corporation Awarded LSDF Grant As Commercialization Partner 3Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2Audicus Will Help People Resolve to Hear Better in 2015 2
... , , ... AMGN ) today announced positive top-line results from a Phase ... irinotecan-based chemotherapy) as a second-line treatment in 1,186 patients with ... progression-free and overall survival. , , ...
... August 17 D-Pharm announced today the,completion of a financial ... the Company,s late stage clinical stroke program. The,financial round combined ... Offering (IPO) of NIS 28 million. The IPO was oversubscribed ... than the minimum price. The,company,s pre-money valuation was NIS 120 ...
Cached Medicine Technology:Vectibix(R) Significantly Improved Progression-Free Survival in Second-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer 2Vectibix(R) Significantly Improved Progression-Free Survival in Second-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer 3Vectibix(R) Significantly Improved Progression-Free Survival in Second-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer 4Vectibix(R) Significantly Improved Progression-Free Survival in Second-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer 5Vectibix(R) Significantly Improved Progression-Free Survival in Second-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer 6Vectibix(R) Significantly Improved Progression-Free Survival in Second-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer 7Vectibix(R) Significantly Improved Progression-Free Survival in Second-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer 8D-Pharm Raises NIS 85 Million in Rights Offering and Initial Public Offering (IPO) on the Tel Aviv Stock Exchange (TASE) 2D-Pharm Raises NIS 85 Million in Rights Offering and Initial Public Offering (IPO) on the Tel Aviv Stock Exchange (TASE) 3
... Thyroid-stimulating hormone (TSH) is a 32 kDa ... the anterior pituitary gland [1]. The structure ... of the pituitary and placental gonadotropins, consisting ... identical between these hormones and a unique ...
... (T4) is the primary active hormone synthesized ... gland [1]. T4 is synthesized via a ... by the follicular cells, (ii) iodination of ... to formation of 3-monoiodotyrosine and 3,5-diiodotyrosine (MIT ...
... primarily by 5-monodeioination of thyroxine (T4) in ... production occurs at a rate which is ... of T3 from the thyroid gland into ... to 80-100 micrograms/day for T4. In addition, ...
... Human Insulin-like growth factor binding protein-3 (IGFBP-3) is ... in postnatal serum, as a component of the ... IGFBP-3, a molecule of IGF-I or IGF-II and ... the actions of the IGFs. The molar concentration ...
Medicine Products: