Navigation Links
Triple negative breast cancer, ethnicity, and socioeconomic status
Date:5/12/2014

ATLANTA May 12, 2014An analysis of a large nationwide dataset finds that regardless of their socioeconomic status, black women were nearly twice as likely as white women to be diagnosed with triple-negative (TN) breast cancer, a subtype that has a poorer prognosis. The analysis also found that Asian/Pacific Islander women were more likely to be diagnosed with another subtype of breast cancer: so-called human epidermal growth factor receptor 2 (HER2)overexpressing breast cancer. The study appears early online in Breast Cancer Research and Treatment.

Triple-negative breast cancers are those whose cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces. Triple-negative breast cancers tend to grow and spread more quickly than most other types of breast cancer, and a lack of these receptors limits treatment options.

Previous studies have indicated that non-Hispanic blacks and Hispanics were more likely to be diagnosed with triple negative breast cancer than non-Hispanic whites. Some studies have suggested that the higher odds of breast cancer subtypes with unfavorable prognoses in minority racial/ethnic groups could be explained by differences in socioeconomic status. However, these studies were limited by their small and incomplete sampling.

For the current study, scientists led by Helmneh Sineshaw, M.D., MPH, analyzed data from 260,174 breast cancer cases recorded in the National Cancer Data Base (NCDB), a national hospital-based cancer registry database jointly sponsored by the American College of Surgeons and the American Cancer Society. The analysis showed that patients with low socioeconomic status had higher proportions of triple negative breast cancers than did patients with high or moderate socioeconomic status. However, even after controlling for socioeconomic status, the difference remained: black women were 1.84 times as likely to be diagnosed with the triple negative subtype. The researchers also found that compared with white women, Asian/Pacific Islander women had higher odds of presenting with HER2-overexpressing breast cancer, a difference that was also observed at every level of socioeconomic status.

"The excess odds of triple negative breast cancer in blacks compared to whites were remarkably similar, about 80% higher, in each socioeconomic group," said Dr. Sineshaw. "That consistent increase suggests factors other than differences in socioeconomic status play a strong role in the excess odds seen in black women. Further studies are needed to identify those factors."


'/>"/>

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society
Source:Eurekalert

Related medicine news :

1. Triple negative breast cancer symposium highlights current advances
2. Infant Vaccination Delays Triple in Oregon: Study
3. Smoking After Stroke Triples Risk of Death Within Year: Study
4. Triple-threat approach reduces life-threatening central line infections in children with cancer
5. Tissue around tumor holds key to fighting triple negative breast cancer
6. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
7. Head Injury Plus Herbicide Exposure May Triple Parkinsons Risk
8. Scientists ID Gene Mutation That May Triple Alzheimers Risk
9. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
10. Survival Tripled for Hospitalized U.S. Kids With Cardiac Arrest
11. Triple Crown Industries and Richie Morris Racing Join Forces with MotoSport.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... 24, 2017 , ... “End Time GPS”: a dauntless and enlightened study ... Time GPS” is the creation of published author, Wesley Gerboth, a World War II ... and space-vehicle projects. Now, at age ninety-one, he shares the Wisdom God bestowed upon ...
(Date:3/24/2017)... ... , ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a ... to the fullest, as God intended. “The Adventures of Joey, The Dog Who Barks ... pursuing her passion for writing, especially about truth and human behavior. , Published by ...
(Date:3/23/2017)... ... ... The physicians of KSF Orthopaedic Center PA are proud to announce the ... located at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 inside the ... living in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) with an ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... Oklahoma City Convention Center at 10 North Broadway Avenue, will be an educational ... of relevant, practical instruction in the management of chronic pain. , Oklahoma is ...
(Date:3/23/2017)... ... ... of adults are unaware of the dangers that infectious bacteria play in mouth disease, while ... a day that dentists recommend. The ramifications of improper oral upkeep go far beyond bad ... 164 million hours of work each year due to dental issues. That is why Mediaplanet ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 23, 2017  Provectus Biopharmaceuticals, Inc. ... "Company"), a clinical-stage oncology and dermatology biopharmaceutical company, ... Financing Commitment Term Sheet (the "Definitive Financing") it ... of the Company,s stockholders, who are referred to ... a Form 8-K filed with the Securities and ...
(Date:3/23/2017)... The key factors driving the growth ... accelerating economic growth and increasing healthcare expenditure. Some of the ... expectancy of ESRD patients, rising demand for home PD treatment ... of the market is hindered by high treatment costs and ... ...
(Date:3/23/2017)... -- As a result of diagnostic technology increasing ... allergic diseases, cutting edge developments in targeted drugs ... in which pharmaceutical and biotech companies are addressing ... both a high quality meeting and a platform ... research scholars and doctors. The event will also ...
Breaking Medicine Technology: